Papers/PMID:42794802
Effect of Sucralose Consumption on Gut Microbiota: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
International journal of molecular sciences2026The record
2 findings · 1 compound · 2 endpoints · 2 null
What it reported
How to read these marksEvery finding here is a null result.
What did not
2 findings
sucralose — no detected effect on HOMA-IR
PreliminaryGrade D, Preliminary. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull result“Sucralose did not significantly alter alpha diversity (Shannon index: SMD = -0.00; 95% CI -1.16 to 1.15; p = 0.99; I2 = 25.67%), fasting blood glucose (SMD = -0.04; 95% CI = -0.63 to 0.56; p = 0.88; I2 = 69.61%), and HOMA-IR (SMD = -0.13; 95% CI = -0.36 to 0.10; p = 0.212; I2 = 0.00%).”
Quoted verbatim from Effect of Sucralose Consumption on Gut Microbiota: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.. - Study
- meta-analysis
- Population
- healthy adults; pooled from randomized controlled trials of sucralose consumption
Effect -0.13 standardised mean difference, 95% CI -0.36 to 0.1
Effect of Sucralose Consumption on Gut Microbiota: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.2026PMID:42794802Permalink
sucralose — no detected effect on fasting blood glucose
PreliminaryGrade D, Preliminary. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull result“Sucralose did not significantly alter alpha diversity (Shannon index: SMD = -0.00; 95% CI -1.16 to 1.15; p = 0.99; I2 = 25.67%), fasting blood glucose (SMD = -0.04; 95% CI = -0.63 to 0.56; p = 0.88; I2 = 69.61%), and HOMA-IR (SMD = -0.13; 95% CI = -0.36 to 0.10; p = 0.212; I2 = 0.00%).”
Quoted verbatim from Effect of Sucralose Consumption on Gut Microbiota: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.. - Study
- meta-analysis
- Population
- healthy adults; pooled from randomized controlled trials of sucralose consumption
Effect -0.04 standardised mean difference, 95% CI -0.63 to 0.56
Effect of Sucralose Consumption on Gut Microbiota: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.2026PMID:42794802Permalink