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Proteins/UNIPROT:O95861
Phosphatase that converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP and inositol 1,4-bisphosphate (Ins(1,4)P2) to inositol 4-phosphate. Is also able to hydrolyze adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) (By similarity). Probably prevents the toxic accumulation of PAP, a compound which inhibits a variety of proteins, including PAPS-utilizing enzymes such as sulfotransferases, and RNA processing enzymes. Could also play a role in inositol recycling and phosphoinositide metabolism. Is not active on 3'-AMP, inositol-1-phosphate and inositol-1,4,5-triphosphate..
Function from UniProtKB (O95861), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
10 statements
10 statements · 4 reference databases · Subject: BPNT1 · Sources: Hetionet, Reactome, Rhea, UniProt
7 reactions
water+adenosine 3',5'-bismonophosphateAMP+phosphate(3-)
Reaction pageLeft to rightBalancedEC 3.1.3.7cytosol
Human-GEM MAR04084CC BY 4.0Reference data
water+3'-phospho-5'-adenylyl sulfateadenosine 5'-phosphosulfate+phosphate(3-)
Catalysed by BPNT1
7 names
Resolves to: BPNT1
Human-GEM MAR04187CC BY 4.0Reference data
adenosine 3',5'-bisphosphate+waterAMP+hydrogenphosphate
Reaction pageLeft to rightBalanced
Rhea RHEA:10040CC BY 4.0Reference data
CHEBI:58282+waterCHEBI:58469+hydrogenphosphate
Reaction pageLeft to rightBalanced
Rhea RHEA:15553CC BY 4.0Reference data
CHEBI:58414+waterCHEBI:83241+hydrogenphosphate
Reaction pageLeft to rightBalanced
Rhea RHEA:70319CC BY 4.0Reference data
3'-phosphoadenylyl sulfate+wateradenosine 5'-phosphosulfate+hydrogenphosphate
Catalysed by BPNT1
Reaction pageLeft to rightBalanced
Rhea RHEA:77639CC BY 4.0Reference data
adenosine 2',5'-bisphosphate+waterAMP+hydrogenphosphate
Catalysed by BPNT1
Reaction pageLeft to rightBalanced
Rhea RHEA:77643CC BY 4.0Reference data