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CompoundsSubstances with curated findings
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Catalyst

The evidence graph for human biochemistry. Every edge carries its source, its study design, and a grade computed from both.

A reference for what the literature reports. Not medical advice.

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Reference data under the licences listed on the attribution page.

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Papers/PMID:41847903

Role of melatonin for prevention of necrotizing enterocolitis in preterm infants: a randomized controlled trial.

Journal of tropical pediatrics2026The record

1 finding drawn from this paper, on 1 compound across 1 endpoint.

melatonin

What it reported

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What moved

1 finding

melatonin — decreases tumour necrosis factor alpha concentration
PreliminaryGrade D, Preliminary. Non-human or in vitro only.Finding
“Enteral melatonin significantly reduced NEC incidence and mortality, accelerated achievement of full enteral feeding, and lowered TNF-α levels in preterm neonates with FI.”
Quoted verbatim from Role of melatonin for prevention of necrotizing enterocolitis in preterm infants: a randomized controlled trial..
Study

RCT
Dose

two doses of 10 mg each, 1 h apart
Population

preterm neonates with feeding intolerance (FI); enteral melatonin plus conventional therapy vs conventional therapy alone, measured 72 h posttreatment
Role of melatonin for prevention of necrotizing enterocolitis in preterm infants: a randomized controlled trial.2026PMID:41847903