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Papers/PMID:36788534

The effect of Curcumin on metabolic parameters and androgen level in women with polycystic ovary syndrome: a randomized controlled trial.

BMC endocrine disorders2023The record

6 findings · 1 compound · 6 endpoints · 6 null

What it reported

How to read these marks

Every finding here is a null result.

What did not

6 findings

  • curcumin — no detected effect on HDL cholesterol

    Evidence strength: moderate.FindingNull resultreplicated ×8
    “After 12 weeks of intervention, the mean (SD) serum HDL level in the curcumin group was 53.77 (13.15) and in the placebo group it was 51.56 (9.74) which means no statistically significant difference between the two groups (MD: 3.22; 95% CI: -3.04 to 9.48; P = 0.306).”
    Quoted verbatim from The effect of Curcumin on metabolic parameters and androgen level in women with polycystic ovary syndrome: a randomized controlled trial..
    Study
    RCT
    Duration
    3 months
    Dose
    two 500 mg curcumin tablets together once daily (1000 mg a day) for twelve weeks
    Population
    Women aged 18 to 45 with polycystic ovary syndrome (Rotterdam criteria), BMI 18.5 to 40, in Eslamshahr, Iran

    Effect 3.22 mean difference, 95% CI -3.04 to 9.48

    The effect of Curcumin on metabolic parameters and androgen level in women with polycystic ovary syndrome: a randomized controlled trial.2023PMID:3678853410.1186/s12902-023-01295-5Industry fundedPermalink

  • curcumin — no detected effect on total testosterone

    Evidence strength: moderate.FindingNull result
    “After the intervention, the mean (SD) serum testosterone level in the curcumin group was 0.64 (0.39) and in the placebo group it was 0.77 (0.36) which means no statistically significant difference between the two groups (0.133).”
    Quoted verbatim from The effect of Curcumin on metabolic parameters and androgen level in women with polycystic ovary syndrome: a randomized controlled trial..
    Study
    RCT
    Duration
    3 months
    Dose
    two 500 mg curcumin tablets together once daily (1000 mg a day) for twelve weeks
    Population
    Women aged 18 to 45 with polycystic ovary syndrome (Rotterdam criteria), BMI 18.5 to 40, in Eslamshahr, Iran; sampled in the follicular phase

    The effect of Curcumin on metabolic parameters and androgen level in women with polycystic ovary syndrome: a randomized controlled trial.2023PMID:3678853410.1186/s12902-023-01295-5Industry fundedPermalink

  • curcumin — no detected effect on LDL cholesterol

    Evidence strength: moderate.FindingNull resultreplicated ×4
    “After 12 weeks of intervention, the mean (SD) serum LDL level in the curcumin group was 89.96 (30.92) and in the placebo group it was 105.70 (29.33) which means no statistically significant difference between the two groups (MD: -14.81; 95% CI: -30.52 to 0.91; P = 0.064).”
    Quoted verbatim from The effect of Curcumin on metabolic parameters and androgen level in women with polycystic ovary syndrome: a randomized controlled trial..
    Study
    RCT
    Duration
    3 months
    Dose
    two 500 mg curcumin tablets together once daily (1000 mg a day) for twelve weeks
    Population
    Women aged 18 to 45 with polycystic ovary syndrome (Rotterdam criteria), BMI 18.5 to 40, in Eslamshahr, Iran

    Effect -14.81 mean difference, 95% CI -30.52 to 0.91

    The effect of Curcumin on metabolic parameters and androgen level in women with polycystic ovary syndrome: a randomized controlled trial.2023PMID:3678853410.1186/s12902-023-01295-5Industry fundedPermalink

  • curcumin — no detected effect on total cholesterol (TC)

    Evidence strength: limited.FindingNull resultreplicated ×3
    “After 12 weeks of intervention, the mean (SD) serum cholesterol level in the curcumin group was 165.85 (37.69) and in the placebo group it was 174.19 (40.93) which means no statistically significant difference between the two groups (MD: -6.25; 95% CI: -26.13 to 13.57; P = 0.528).”
    Quoted verbatim from The effect of Curcumin on metabolic parameters and androgen level in women with polycystic ovary syndrome: a randomized controlled trial..
    Study
    RCT
    Duration
    3 months
    Dose
    two 500 mg curcumin tablets together once daily (1000 mg a day) for twelve weeks
    Population
    Women aged 18 to 45 with polycystic ovary syndrome (Rotterdam criteria), BMI 18.5 to 40, in Eslamshahr, Iran

    Effect -6.25 mean difference, 95% CI -26.13 to 13.57

    The effect of Curcumin on metabolic parameters and androgen level in women with polycystic ovary syndrome: a randomized controlled trial.2023PMID:3678853410.1186/s12902-023-01295-5Industry fundedPermalink

  • curcumin — no detected effect on triglycerides

    Evidence strength: limited.FindingNull resultreplicated ×2
    “After 12 weeks of intervention, the mean (SD) serum triglyceride level in the curcumin group was 128.02 (6.13) and in the placebo group it was 136.27 (6.00) which means no statistically significant difference between the two groups (MD: -8.25; 95% CI: -25.85 to 9.35; P = 0.351).”
    Quoted verbatim from The effect of Curcumin on metabolic parameters and androgen level in women with polycystic ovary syndrome: a randomized controlled trial..
    Study
    RCT
    Duration
    3 months
    Dose
    two 500 mg curcumin tablets together once daily (1000 mg a day) for twelve weeks
    Population
    Women aged 18 to 45 with polycystic ovary syndrome (Rotterdam criteria), BMI 18.5 to 40, in Eslamshahr, Iran

    Effect -8.25 mean difference, 95% CI -25.85 to 9.35

    The effect of Curcumin on metabolic parameters and androgen level in women with polycystic ovary syndrome: a randomized controlled trial.2023PMID:3678853410.1186/s12902-023-01295-5Industry fundedPermalink

  • curcumin — no detected effect on HOMA-IR

    Evidence strength: limited.FindingNull result
    “After 12 weeks of intervention, the mean (SD) serum HOMA-IR in the curcumin group was 2.11 (1.79) and in the placebo group it was 2.40 (2.11) which means no statistically significant difference between the two groups (P = 0.736).”
    Quoted verbatim from The effect of Curcumin on metabolic parameters and androgen level in women with polycystic ovary syndrome: a randomized controlled trial..
    Study
    RCT
    Duration
    3 months
    Dose
    two 500 mg curcumin tablets together once daily (1000 mg a day) for twelve weeks
    Population
    Women aged 18 to 45 with polycystic ovary syndrome (Rotterdam criteria), BMI 18.5 to 40, in Eslamshahr, Iran

    The effect of Curcumin on metabolic parameters and androgen level in women with polycystic ovary syndrome: a randomized controlled trial.2023PMID:3678853410.1186/s12902-023-01295-5Industry fundedPermalink