Papers/PMID:36156660
Cancer Risk in Children of Mothers With Epilepsy and High-Dose Folic Acid Use During Pregnancy.
JAMA neurology2022The record
1 finding · 1 compound · 1 endpoint
What it reported
How to read these marksWhat moved
1 finding
folic acid — increases all-site cancer incidence
Evidence strength: very limited.Finding“In children of mothers with epilepsy who filled prescriptions for ASM, a 3.0-fold (95% CI, 1.1-fold to 7.9-fold) increased risk of childhood cancer associated with exposure to high-dose folic acid was observed.”
Quoted verbatim from Cancer Risk in Children of Mothers With Epilepsy and High-Dose Folic Acid Use During Pregnancy.. - Study
- cohort
- Dose
- high-dose folic acid, at least 1 filled prescription of 1 mg or 5 mg tablets between 90 days before pregnancy and birth
- Population
- Children of mothers with epilepsy who filled antiseizure medication prescriptions (Denmark, Norway, Sweden registers); prenatal exposure to filled prescriptions of high-dose folic acid (1 mg or 5 mg tablets) versus none; subgroup of mothers with epilepsy using antiseizure medication, cancer before age 20
Cancer Risk in Children of Mothers With Epilepsy and High-Dose Folic Acid Use During Pregnancy.2022PMID:3615666010.1001/jamaneurol.2022.2977Permalink