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folic acid/Finding

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A single claim from the graph, with the evidence strength computed from its study, the sentence it was drawn from, and the paper. This address does not change.

  • folic acid — increases all-site cancer incidence

    Evidence strength: very limited.Finding
    “In children of mothers with epilepsy who filled prescriptions for ASM, a 3.0-fold (95% CI, 1.1-fold to 7.9-fold) increased risk of childhood cancer associated with exposure to high-dose folic acid was observed.”
    Quoted verbatim from Cancer Risk in Children of Mothers With Epilepsy and High-Dose Folic Acid Use During Pregnancy..
    Study
    cohort
    Dose
    high-dose folic acid, at least 1 filled prescription of 1 mg or 5 mg tablets between 90 days before pregnancy and birth
    Population
    Children of mothers with epilepsy who filled antiseizure medication prescriptions (Denmark, Norway, Sweden registers); prenatal exposure to filled prescriptions of high-dose folic acid (1 mg or 5 mg tablets) versus none; subgroup of mothers with epilepsy using antiseizure medication, cancer before age 20

    Cancer Risk in Children of Mothers With Epilepsy and High-Dose Folic Acid Use During Pregnancy.2022PMID:3615666010.1001/jamaneurol.2022.2977Permalink

To cite this finding: https://catalystproject.ai/e/01M5SB95STWBEN9R9C2QTBAK6J

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