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Papers/PMID:34392848

Associations between early thiamine administration and clinical outcomes in critically ill patients with acute kidney injury.

The British journal of nutrition2022The record

1 finding · 1 compound · 1 endpoint

What it reported

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What moved

1 finding

  • thiamine — decreases all-cause mortality

    Evidence strength: very limited.Findingreplicated ×9
    “Early thiamine use was associated with lower in-hospital mortality (OR 0·65; 95 % CI 0·49, 0·87; P < 0·001) and 90-d mortality (OR 0·58; 95 % CI 0·45, 0·74; P < 0·001), and it was also associated with the recovery of renal function (OR 1·26; 95 % CI 1·17, 1·36; P < 0·001).”
    Quoted verbatim from Associations between early thiamine administration and clinical outcomes in critically ill patients with acute kidney injury..
    Study
    cohort
    Duration
    3 months
    Population
    Critically ill adults with acute kidney injury in the MIMIC III database, propensity-score matched; early thiamine (within 48 h of ICU admission) versus none; 90-day horizon

    Effect 0.58 odds ratio, 95% CI 0.45 to 0.74

    Associations between early thiamine administration and clinical outcomes in critically ill patients with acute kidney injury.2022PMID:3439284810.1017/S0007114521003111Permalink