Papers/PMID:33595634
Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19: A Randomized Clinical Trial.
JAMA2021The record
3 findings · 1 compound · 3 endpoints · 2 null
What it reported
How to read these marksWhat moved
1 finding
calciol — increases serum 25-hydroxyvitamin D concentration
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Findingreplicated ×13“Mean serum levels of 25-hydroxyvitamin D significantly increased after a single dose of vitamin D3 vs placebo (44.4 ng/mL vs 19.8 ng/mL; difference, 24.1 ng/mL [95% CI, 19.5-28.7]; P < .001).”
Quoted verbatim from Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19: A Randomized Clinical Trial.. - Study
- RCT
- Dose
- single oral dose of 200,000 IU vitamin D3 versus placebo
- Population
- Hospitalised adults with moderate to severe COVID-19 at two sites in Sao Paulo, Brazil
Effect 24.1 mean difference, 95% CI 19.5 to 28.7
Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19: A Randomized Clinical Trial.2021PMID:33595634Permalink
What did not
2 findings
calciol — no detected effect on hospital length of stay
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull result“Median (interquartile range) length of stay was not significantly different between the vitamin D3 (7.0 [4.0-10.0] days) and placebo groups (7.0 [5.0-13.0] days) (log-rank P = .59; unadjusted hazard ratio for hospital discharge, 1.07 [95% CI, 0.82-1.39]; P = .62).”
Quoted verbatim from Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19: A Randomized Clinical Trial.. - Study
- RCT
- Dose
- single oral dose of 200,000 IU vitamin D3 versus placebo
- Population
- Hospitalised adults with moderate to severe COVID-19 at two sites in Sao Paulo, Brazil
Effect 1.07 hazard ratio, 95% CI 0.82 to 1.39
Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19: A Randomized Clinical Trial.2021PMID:33595634Permalink
calciol — no detected effect on all-cause mortality
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull resultreplicated ×1“The difference between the vitamin D3 group and the placebo group was not significant for in-hospital mortality (7.6% vs 5.1%; difference, 2.5% [95% CI, -4.1% to 9.2%]; P = .43), admission to the intensive care unit (16.0% vs 21.2%; difference, -5.2% [95% CI, -15.1% to 4.7%]; P = .30), or need for mechanical ventilation (7.6% vs 14.4%; difference, -6.8% [95% CI, -15.1% to 1.2%]; P = .09).”
Quoted verbatim from Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19: A Randomized Clinical Trial.. - Study
- RCT
- Dose
- single oral dose of 200,000 IU vitamin D3 versus placebo
- Population
- Hospitalised adults with moderate to severe COVID-19 at two sites in Sao Paulo, Brazil; mortality during hospitalisation
Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19: A Randomized Clinical Trial.2021PMID:33595634Permalink