PapersPMID:33546717
Intra-articular magnesium to alleviate postoperative pain after arthroscopic knee surgery: a meta-analysis of randomized controlled trials.
- findings
- 2
- compound
- 1
- endpoints
- 2
magnesium(2+)- Study, every finding
- meta-analysis
- Dose studied, every finding
- intra-articular magnesium, per-trial doses from 0.15 g to 1.5 g in 10 to 30 mL (one trial 10 mg/kg)
What moved
How to read these marks →“As shown in Fig. 6, IA Mg was associated with significantly prolonging of the time to analgesic requirement (MD = 329.99, 95% CI: 228.73–431.24; p < 0.00001; I2 = 99%) (Table 2).”
- Effect
- 329.99 mean difference, 95% CI 228.73 to 431.24
- Population
- Adults after arthroscopic knee surgery; eleven pooled randomised trials of intra-articular magnesium (alone or with a local anaesthetic) against saline or the same local anaesthetic alone; time to first analgesic request in minutes
- Decreases visual analogue scale pain intensity
moderatereplicated ×4
“As shown in Fig. 4, IA Mg was associated with significantly lower VAS scores at postoperative 2 h (MD = − 0.46, 95% CI: − 0.64 to − 0.27; p = 0.14; I2 = 39%), 4 h (MD = − 0.85, 95% CI: − 1.40 to − 0.30; p < 0.0001; I2 = 95%), 12 h (MD = − 0.83, 95% CI: − 1.17 to − 0.48; p = 0.004; I2 = 71%), and 24 h (MD = − 0.58, 95% CI: − 0.79 to − 0.36; p = 0.05; I2 = 45%) (Table 2).”
- Effect
- −0.58 mean difference, 95% CI −0.79 to −0.36
- Population
- Adults after arthroscopic knee surgery; pooled randomised trials of intra-articular magnesium (alone or with a local anaesthetic) against saline or the same local anaesthetic alone; pain with movement on a 0-10 VAS, 24 hours after surgery
Study record
- Design
- meta-analysis
- Species
- human
- Population
- Adults undergoing arthroscopic knee surgery (meniscectomy, ACL reconstruction, general arthroscopy); 11 RCTs, 677 participants
- Participants
- 677
- Comparator
- an active treatment / placebo
- Duration
- not reported
- Endpoints measured
- 11