Papers/PMID:32697483
Association Between IV Thiamine and Mortality in Patients With Septic Shock: A Nationwide Observational Study.
Critical care medicine2020The record
1 finding · 1 compound · 1 endpoint · 1 null
What it reported
How to read these marksEvery finding here is a null result.
What did not
1 finding
thiamine — no detected effect on all-cause mortality
Evidence strength: very limited.FindingNull resultreplicated ×1“The findings of this nationwide database-based observational study did not support an association between thiamine administration early after admission and the 28-day mortality in patients with septic shock.”
Quoted verbatim from Association Between IV Thiamine and Mortality in Patients With Septic Shock: A Nationwide Observational Study.. - Study
- cohort
- Duration
- 4 weeks
- Dose
- 100 mg or 200 mg per day within 2 days of admission
- Population
- Patients with septic shock requiring norepinephrine within 2 days of admission, Japanese nationwide database; thiamine 100 mg or more within 2 days of admission versus no thiamine, inverse probability of treatment weighting
Association Between IV Thiamine and Mortality in Patients With Septic Shock: A Nationwide Observational Study.2020PMID:3269748310.1097/CCM.0000000000004394Permalink