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Papers/PMID:30028362

Effect of Thiamine Administration on Lactate Clearance and Mortality in Patients With Septic Shock.

Critical care medicine2018The record

1 finding · 1 compound · 1 endpoint

What it reported

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What moved

1 finding

  • thiamine — decreases all-cause mortality

    Evidence strength: very limited.Findingreplicated ×9
    “Thiamine administration was also associated with a reduction in 28-day mortality (hazard ratio, 0.666; 95% CI, 0.490-0.905).”
    Quoted verbatim from Effect of Thiamine Administration on Lactate Clearance and Mortality in Patients With Septic Shock..
    Study
    cohort
    Duration
    4 weeks
    Dose
    IV thiamine within 24 hours of hospital admission
    Population
    Adults with septic shock admitted to medicine or surgery ICU; 123 thiamine-treated patients matched with 246 patients not receiving thiamine; retrospective single-center matched cohort

    Effect 0.666 hazard ratio, 95% CI 0.49 to 0.905

    Effect of Thiamine Administration on Lactate Clearance and Mortality in Patients With Septic Shock.2018PMID:3002836210.1097/CCM.0000000000003311Permalink