Papers/PMID:26536464
Green Tea Extract Rich in Epigallocatechin-3-Gallate Prevents Fatty Liver by AMPK Activation via LKB1 in Mice Fed a High-Fat Diet.
PloS one2015The record
3 findings · 1 compound · 3 endpoints
What it reported
How to read these marksWhat moved
3 findings
(-)-epigallocatechin 3-gallate — decreases body mass
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Findingreplicated ×3“Nevertheless, the body weight of mice belonging to the CE group was significantly lower than those belonging to the CW group, starting at the fourth week until the end of experimental treatment (p < 0.001).”
Quoted verbatim from Green Tea Extract Rich in Epigallocatechin-3-Gallate Prevents Fatty Liver by AMPK Activation via LKB1 in Mice Fed a High-Fat Diet.. - Study
- animal · not in humans
- Duration
- 4 months
- Dose
- green tea extract 98% EGCG, 50 mg/kg/day by gavage
- Population
- Male Swiss mice on a control diet (AIN-93), CE group (green tea extract) versus CW group (water by gavage), 16 weeks; difference from week 4 onward
Green Tea Extract Rich in Epigallocatechin-3-Gallate Prevents Fatty Liver by AMPK Activation via LKB1 in Mice Fed a High-Fat Diet.2015PMID:26536464Permalink
(-)-epigallocatechin 3-gallate — increases serum adiponectin
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“Adiponectin presented a significantly higher level in the HFE group as compared with the HFW group (p = 0.031) and in the CE group as compared with the CW group (p = 0.046).”
Quoted verbatim from Green Tea Extract Rich in Epigallocatechin-3-Gallate Prevents Fatty Liver by AMPK Activation via LKB1 in Mice Fed a High-Fat Diet.. - Study
- animal · not in humans
- Duration
- 4 months
- Dose
- green tea extract 98% EGCG, 50 mg/kg/day by gavage
- Population
- Male Swiss mice after 16 weeks, 12-hour fasted; green tea extract versus water by gavage in both high-fat-diet mice (HFE vs HFW) and control-diet mice (CE vs CW)
Green Tea Extract Rich in Epigallocatechin-3-Gallate Prevents Fatty Liver by AMPK Activation via LKB1 in Mice Fed a High-Fat Diet.2015PMID:26536464Permalink
(-)-epigallocatechin 3-gallate — decreases LDL cholesterol
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Findingreplicated ×1“LDL-c level was also reduced in the HFE group as compared with the HFW group (p = 0.011).”
Quoted verbatim from Green Tea Extract Rich in Epigallocatechin-3-Gallate Prevents Fatty Liver by AMPK Activation via LKB1 in Mice Fed a High-Fat Diet.. - Study
- animal · not in humans
- Duration
- 4 months
- Dose
- green tea extract 98% EGCG, 50 mg/kg/day by gavage
- Population
- Male Swiss mice fed a high-fat diet for 16 weeks, green tea extract (HFE) versus water by gavage (HFW), 12-hour fasted
Green Tea Extract Rich in Epigallocatechin-3-Gallate Prevents Fatty Liver by AMPK Activation via LKB1 in Mice Fed a High-Fat Diet.2015PMID:26536464Permalink