Papers/PMID:26086941
Effect of Cholecalciferol Supplementation on Vitamin D Status and Cathelicidin Levels in Sepsis: A Randomized, Placebo-Controlled Trial.
Critical care medicine2015The record
2 findings · 1 compound · 2 endpoints · 2 null
What it reported
How to read these marksEvery finding here is a null result.
What did not
2 findings
calciol — no detected effect on intensive care unit length of stay
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“When the two cholecalciferol groups were combined into a single intervention arm and compared to the placebo group, there was no difference is ICU LOS: 12 (IQR 7 to 15) days for the placebo group versus 3 (IQR 3 to 12) days for the cholecalciferol group (p=0.77).”
Quoted verbatim from Effect of Cholecalciferol Supplementation on Vitamin D Status and Cathelicidin Levels in Sepsis: A Randomized, Placebo-Controlled Trial.. - Study
- RCT
- Dose
- single bolus of 200,000 IU or 400,000 IU cholecalciferol (arms combined), versus matched placebo
- Population
- Adult ICU patients within 24 hours of new-onset severe sepsis or septic shock; post-hoc analysis combining the 200,000 IU and 400,000 IU cholecalciferol arms against placebo
Effect of Cholecalciferol Supplementation on Vitamin D Status and Cathelicidin Levels in Sepsis: A Randomized, Placebo-Controlled Trial.2015PMID:26086941Permalink
calciol — no detected effect on all-cause mortality
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull resultreplicated ×5“And while 30-day ICU readmission rate was still higher in the placebo group compared to the cholecalciferol group (20% versus 0%; p<0.001, respectively), there was no difference between them in terms of 30-day all-cause mortality (30% versus 25%; p=0.43, respectively).”
Quoted verbatim from Effect of Cholecalciferol Supplementation on Vitamin D Status and Cathelicidin Levels in Sepsis: A Randomized, Placebo-Controlled Trial.. - Study
- RCT
- Duration
- 4 weeks
- Dose
- single bolus of 200,000 IU or 400,000 IU cholecalciferol (arms combined), versus matched placebo
- Population
- Adult ICU patients within 24 hours of new-onset severe sepsis or septic shock; post-hoc analysis combining the 200,000 IU and 400,000 IU cholecalciferol arms against placebo; 30-day horizon
Effect of Cholecalciferol Supplementation on Vitamin D Status and Cathelicidin Levels in Sepsis: A Randomized, Placebo-Controlled Trial.2015PMID:26086941Permalink