Papers/PMID:25441767
Efficacy of methylene blue in an experimental model of calcium channel blocker-induced shock.
Annals of emergency medicine2015The record
1 finding · 1 compound · 1 endpoint
What it reported
How to read these marksWhat moved
1 finding
methylene blue — increases mean arterial pressure in vasodilatory shock
InsufficientEvidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited.Finding“The MAP was significantly higher in the methylene blue-treated group starting 25 min after the amlodipine infusion (95% CI, 2–30) that was analyzed up until 60 minutes.”
Quoted verbatim from Efficacy of methylene blue in an experimental model of calcium channel blocker-induced shock.. - Study
- animal · not in humans
- Dose
- 2 mg/kg over 5 minutes at minutes 5, 30 and 60
- Population
- anaesthetised, ventilated Sprague-Dawley rats given an LD50 amlodipine infusion (17 mg/kg/hour) in both arms; MB or normal saline given at minutes 5, 30 and 60; MAP analysed from minute 25 to minute 60
Efficacy of methylene blue in an experimental model of calcium channel blocker-induced shock.2015PMID:25441767Permalink