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Papers/PMID:25268295

Effect of high-dose vitamin D3 on hospital length of stay in critically ill patients with vitamin D deficiency: the VITdAL-ICU randomized clinical trial.

JAMA2014The record

2 findings · 1 compound · 2 endpoints · 2 null

What it reported

How to read these marks

Every finding here is a null result.

What did not

2 findings

  • calciol — no detected effect on hospital length of stay

    Evidence strength: very limited.FindingNull resultreplicated ×1
    “The median (IQR) length of hospital stay was not significantly different between groups (20.1 days [IQR, 11.1-33.3] for vitamin D3 vs 19.3 days [IQR, 11.1-34.9] for placebo; P = .98).”
    Quoted verbatim from Effect of high-dose vitamin D3 on hospital length of stay in critically ill patients with vitamin D deficiency: the VITdAL-ICU randomized clinical trial..
    Study
    RCT
    Duration
    6 months
    Dose
    vitamin D3 540,000 IU once, then 90,000 IU monthly for 5 months, versus placebo
    Population
    Critically ill adult patients in ICUs with vitamin D deficiency (25-hydroxyvitamin D 20 ng/mL or below)

    Effect of high-dose vitamin D3 on hospital length of stay in critically ill patients with vitamin D deficiency: the VITdAL-ICU randomized clinical trial.2014PMID:2526829510.1001/jama.2014.13204Permalink

  • calciol — no detected effect on all-cause mortality

    Evidence strength: very limited.FindingNull resultreplicated ×5
    “Hospital mortality and 6-month mortality were also not significantly different (hospital mortality: 28.3% [95% CI, 22.6%-34.5%] for vitamin D3 vs 35.3% [95% CI, 29.2%-41.7%] for placebo; hazard ratio [HR], 0.81 [95% CI, 0.58-1.11]; P = .18; 6-month mortality: 35.0% [95% CI, 29.0%-41.5%] for vitamin D3 vs 42.9% [95% CI, 36.5%-49.4%] for placebo; HR, 0.78 [95% CI, 0.58-1.04]; P = .09).”
    Quoted verbatim from Effect of high-dose vitamin D3 on hospital length of stay in critically ill patients with vitamin D deficiency: the VITdAL-ICU randomized clinical trial..
    Study
    RCT
    Duration
    6 months
    Dose
    vitamin D3 540,000 IU once, then 90,000 IU monthly for 5 months, versus placebo
    Population
    Critically ill adult patients in ICUs with vitamin D deficiency (25-hydroxyvitamin D 20 ng/mL or below); 6-month mortality horizon

    Effect of high-dose vitamin D3 on hospital length of stay in critically ill patients with vitamin D deficiency: the VITdAL-ICU randomized clinical trial.2014PMID:2526829510.1001/jama.2014.13204Permalink