Papers/PMID:25212718
Sodium bicarbonate in the prevention of cardiac surgery-associated acute kidney injury: a systematic review and meta-analysis.
Critical care (London, England)2014The record
3 findings · 1 compound · 3 endpoints · 1 null
What it reported
How to read these marksWhat moved
2 findings
sodium hydrogencarbonate — increases duration of mechanical ventilation
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“However, SBIC was associated with significant increases in the duration of ventilation (WMD = 0.64 hours; 95% CI = 0.16 to 1.11 hours; P = 0.008; Figure 6), ICU length of stay (WMD = 2.06 days; 95% CI = 0.54 to 3.58 days; P = 0.008; Figure 7), and incidence of alkalemia (RR = 2.21; 95% CI = 1.42 to 3.42; P < 0.001; Additional file 4).”
Quoted verbatim from Sodium bicarbonate in the prevention of cardiac surgery-associated acute kidney injury: a systematic review and meta-analysis.. - Study
- meta-analysis
- Dose
- intravenous bolus plus continuous infusion, regimens varied across trials
- Population
- Adults undergoing cardiac surgery with cardiopulmonary bypass, most with pre-existing renal impairment or at risk of acute kidney injury; secondary endpoint pooled from four randomized trials
Effect 0.64 mean difference, 95% CI 0.16 to 1.11
Sodium bicarbonate in the prevention of cardiac surgery-associated acute kidney injury: a systematic review and meta-analysis.2014PMID:25212718Permalink
sodium hydrogencarbonate — increases intensive care unit length of stay
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“However, SBIC was associated with significant increases in the duration of ventilation (WMD = 0.64 hours; 95% CI = 0.16 to 1.11 hours; P = 0.008; Figure 6), ICU length of stay (WMD = 2.06 days; 95% CI = 0.54 to 3.58 days; P = 0.008; Figure 7), and incidence of alkalemia (RR = 2.21; 95% CI = 1.42 to 3.42; P < 0.001; Additional file 4).”
Quoted verbatim from Sodium bicarbonate in the prevention of cardiac surgery-associated acute kidney injury: a systematic review and meta-analysis.. - Study
- meta-analysis
- Dose
- intravenous bolus plus continuous infusion, regimens varied across trials
- Population
- Adults undergoing cardiac surgery with cardiopulmonary bypass, most with pre-existing renal impairment or at risk of acute kidney injury; secondary endpoint pooled from four randomized trials
Effect 2.06 mean difference, 95% CI 0.54 to 3.58
Sodium bicarbonate in the prevention of cardiac surgery-associated acute kidney injury: a systematic review and meta-analysis.2014PMID:25212718Permalink
What did not
1 finding
sodium hydrogencarbonate — no detected effect on all-cause mortality
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull resultreplicated ×1“Compared with placebo, SBIC did not alter the clinical outcomes of HLOS (WMD = 0.23 days; 95% CI = −0.88 to 1.33 days; P = 0.688; Figure 4), hospital mortality (RR = 1.37; 95% CI = 0.46 to 4.13; P = 0.572; Figure 5), RRT (RR = 0.94; 95% CI = 0.49 to 1.82; P = 0.861; Additional file 2), or POAF (RR = 1.02; 95% CI = 0.65 to 1.61; P = 0.915; Additional file 3).”
Quoted verbatim from Sodium bicarbonate in the prevention of cardiac surgery-associated acute kidney injury: a systematic review and meta-analysis.. - Study
- meta-analysis
- Dose
- intravenous bolus plus continuous infusion, regimens varied across trials
- Population
- Adults undergoing cardiac surgery with cardiopulmonary bypass, most with pre-existing renal impairment or at risk of acute kidney injury; secondary endpoint pooled from four randomized trials; horizon is hospital mortality
Effect 1.37 risk ratio, 95% CI 0.46 to 4.13
Sodium bicarbonate in the prevention of cardiac surgery-associated acute kidney injury: a systematic review and meta-analysis.2014PMID:25212718Permalink