Papers/PMID:23887235
Calcium supplementation during sepsis exacerbates organ failure and mortality via calcium/calmodulin-dependent protein kinase kinase signaling.
Critical care medicine2013The record
1 finding · 1 compound · 1 endpoint
What it reported
How to read these marksWhat moved
1 finding
Ca(2+) — increases all-cause mortality
Evidence strength: insufficient.Finding“By comparison to NS, CaCl2 (0.25 mg/kg) increased mortality: 8.3% vs. 50% (p=0.01).”
Quoted verbatim from Calcium supplementation during sepsis exacerbates organ failure and mortality via calcium/calmodulin-dependent protein kinase kinase signaling.. - Study
- animal · not in humans
- Dose
- CaCl2 0.25 mg/kg intraperitoneal, single dose 12 hours after cecal ligation and puncture
- Population
- Male C57BL/6J mice, 6 to 8 weeks old, with cecal ligation and puncture sepsis; CaCl2 0.25 mg/kg versus normal saline control given 12 hours after surgery
Calcium supplementation during sepsis exacerbates organ failure and mortality via calcium/calmodulin-dependent protein kinase kinase signaling.2013PMID:2388723510.1097/CCM.0b013e31828cf436Permalink