Papers/PMID:23465594
Increased dietary fat contributes to dysregulation of the LKB1/AMPK pathway and increased damage in a mouse model of early-stage ethanol-mediated steatosis.
The Journal of nutritional biochemistry2013The record
1 finding · 1 compound · 1 endpoint
What it reported
How to read these marksWhat moved
1 finding
ethanol — increases alanine aminotransferase
InsufficientEvidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited.Finding“Chronic ethanol consumption resulted in significant increases in plasma alanine aminotransferase in MF (1.84-fold) and HF mice (2.33-fold), yet liver triglycerides only increased significantly in the HF model (1.62-fold).”
Quoted verbatim from Increased dietary fat contributes to dysregulation of the LKB1/AMPK pathway and increased damage in a mouse model of early-stage ethanol-mediated steatosis.. - Study
- animal · not in humans
- Duration
- 6 weeks
- Dose
- ethanol 2%-6% in modified Lieber-DeCarli liquid diet, increasing concentrations, 6 weeks
- Population
- Male C57BL/6J mice pair-fed a modified Lieber-DeCarli diet with moderate fat or high fat calories, with ethanol versus the same diet without ethanol
Increased dietary fat contributes to dysregulation of the LKB1/AMPK pathway and increased damage in a mouse model of early-stage ethanol-mediated steatosis.2013PMID:23465594Permalink