Papers/PMID:23129488
Melatonin for sleep problems in children with neurodevelopmental disorders: randomised double masked placebo controlled trial.
BMJ (Clinical research ed.)2012The record
2 findings · 1 compound · 2 endpoints
What it reported
How to read these marksWhat moved
2 findings
melatonin — increases total sleep time
Evidence strength: moderate.Findingreplicated ×5“Melatonin increased total sleep time as measured with sleep diaries (P=0.04), the primary outcome, but the confidence interval excluded the 60 minute value determined to be the minimum clinically relevant.”
Quoted verbatim from Melatonin for sleep problems in children with neurodevelopmental disorders: randomised double masked placebo controlled trial.. - Study
- RCT
- Duration
- 3 months
- Dose
- immediate release melatonin 0.5 mg titrated through 2 mg and 6 mg to a maximum of 12 mg, 45 minutes before bedtime, for 12 weeks
- Population
- Children aged 3 years to 15 years 8 months with neurodevelopmental disorders and a severe sleep problem; total sleep time by parent-completed sleep diary at 12 weeks
Melatonin for sleep problems in children with neurodevelopmental disorders: randomised double masked placebo controlled trial.2012PMID:2312948810.1136/bmj.e6664Permalink
melatonin — decreases sleep onset latency
Evidence strength: moderate.Findingreplicated ×10“Melatonin reduced sleep onset latency when measured by both sleep diaries (P<0.001) and actigraphy (P<0.001).”
Quoted verbatim from Melatonin for sleep problems in children with neurodevelopmental disorders: randomised double masked placebo controlled trial.. - Study
- RCT
- Duration
- 3 months
- Dose
- immediate release melatonin 0.5 mg titrated through 2 mg and 6 mg to a maximum of 12 mg, 45 minutes before bedtime, for 12 weeks
- Population
- Children aged 3 years to 15 years 8 months with neurodevelopmental disorders and a severe sleep problem; sleep onset latency by sleep diary and actigraphy at 12 weeks
Melatonin for sleep problems in children with neurodevelopmental disorders: randomised double masked placebo controlled trial.2012PMID:2312948810.1136/bmj.e6664Permalink