Papers/PMID:22925537
Effects of a 1-year supplementation with cholecalciferol on interleukin-6, tumor necrosis factor-alpha and insulin resistance in overweight and obese subjects.
Cytokine2012The record
3 findings · 1 compound · 3 endpoints · 1 null
What it reported
How to read these marksWhat moved
2 findings
calciol — decreases interleukin-6 concentration
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Findingreplicated ×1“One year intervention with vitamin D decreased serum IL-6 levels; however hs-CRP levels were significantly increased.”
Quoted verbatim from Effects of a 1-year supplementation with cholecalciferol on interleukin-6, tumor necrosis factor-alpha and insulin resistance in overweight and obese subjects.. - Study
- RCT
- Duration
- 12 months
- Dose
- cholecalciferol 40,000 IU per week or 20,000 IU per week
- Population
- Overweight and obese subjects; 1-year randomised intervention, two weekly cholecalciferol doses against placebo, reported together
Effects of a 1-year supplementation with cholecalciferol on interleukin-6, tumor necrosis factor-alpha and insulin resistance in overweight and obese subjects.2012PMID:22925537Permalink
calciol — increases C-reactive protein concentration
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“One year intervention with vitamin D decreased serum IL-6 levels; however hs-CRP levels were significantly increased.”
Quoted verbatim from Effects of a 1-year supplementation with cholecalciferol on interleukin-6, tumor necrosis factor-alpha and insulin resistance in overweight and obese subjects.. - Study
- RCT
- Duration
- 12 months
- Dose
- cholecalciferol 40,000 IU per week or 20,000 IU per week
- Population
- Overweight and obese subjects; 1-year randomised intervention, two weekly cholecalciferol doses against placebo, reported together
Effects of a 1-year supplementation with cholecalciferol on interleukin-6, tumor necrosis factor-alpha and insulin resistance in overweight and obese subjects.2012PMID:22925537Permalink
What did not
1 finding
calciol — no detected effect on tumour necrosis factor alpha concentration
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull result“Neither measures of insulin resistance, nor TNF-α were influenced by a 1-year vitamin D supplementation.”
Quoted verbatim from Effects of a 1-year supplementation with cholecalciferol on interleukin-6, tumor necrosis factor-alpha and insulin resistance in overweight and obese subjects.. - Study
- RCT
- Duration
- 12 months
- Dose
- cholecalciferol 40,000 IU per week or 20,000 IU per week
- Population
- Overweight and obese subjects; 1-year randomised intervention, two weekly cholecalciferol doses against placebo, reported together
Effects of a 1-year supplementation with cholecalciferol on interleukin-6, tumor necrosis factor-alpha and insulin resistance in overweight and obese subjects.2012PMID:22925537Permalink