Papers/PMID:22498220
Evaluation of vitamin E and selenium supplementation for the prevention of bladder cancer in SWOG coordinated SELECT.
The Journal of urology2012The record
1 finding · 1 compound · 1 endpoint · 1 null
What it reported
How to read these marksEvery finding here is a null result.
What did not
1 finding
α-tocopherol — no detected effect on urinary bladder cancer incidence
Evidence strength: moderate.FindingNull resultreplicated ×1“The bladder cancer rate was higher in the 3 treatment arms than in the placebo arm but no difference was statistically significant (vitamin E HR 1.06, 99% CI 0.72 – 1.53, selenium HR 1.13, 99% CI 0.78–1.63, vitamin E plus selenium HR 1.05, 99% CI 0.71 – 1.51).”
Quoted verbatim from Evaluation of vitamin E and selenium supplementation for the prevention of bladder cancer in SWOG coordinated SELECT.. - Study
- RCT
- Dose
- 400 IU daily all-rac-alpha-tocopheryl acetate
- Population
- Men aged 50 or older (55 or older if not black) without prior prostate cancer in SELECT; vitamin E alone arm vs placebo, 2x2 factorial with selenium; secondary analysis
Effect 1.06 hazard ratio, 95% CI 0.72 to 1.53
Evaluation of vitamin E and selenium supplementation for the prevention of bladder cancer in SWOG coordinated SELECT.2012PMID:2249822010.1016/j.juro.2012.01.117Permalink