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Papers/PMID:21990298

Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT).

JAMA2011The record

1 finding · 1 compound · 1 endpoint

What it reported

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What moved

1 finding

  • α-tocopherol — increases prostate cancer incidence

    Evidence strength: limited.Finding
    “The rate of prostate cancer detection was greater in all treatment groups when compared with placebo but was statistically significant only in the vitamin E alone group (HR 1.17, 99% CI 1.004-1.36, p=0.008) (Table 3).”
    Quoted verbatim from Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT)..
    Study
    RCT
    Dose
    400 IU/day all rac-alpha-tocopheryl acetate, planned follow-up 7 to 12 years
    Population
    Healthy men aged 50 or older (black men) or 55 or older (others), PSA 4 ng/mL or less, in the four-arm SELECT trial; vitamin E alone arm (with selenium placebo) against placebo plus placebo; extended follow-up through July 2011

    Effect 1.17 hazard ratio, 95% CI 1.004 to 1.36

    Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT).2011PMID:2199029810.1001/jama.2011.1437Industry fundedPermalink