Papers/PMID:21060040
Age-related cataract in a randomized trial of vitamins E and C in men.
Archives of ophthalmology (Chicago, Ill. : 1960)2010The record
3 findings · 1 compound · 3 endpoints · 3 null
What it reported
How to read these marksEvery finding here is a null result.
What did not
3 findings
L-ascorbic acid — no detected effect on nuclear cataract incidence
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“For subtypes, there were no significant effects of vitamin C on incidence of nuclear (HR, 1.01; CI, 0.89-1.14), cortical (HR, 1.10; CI, 0.92-1.31), or PSC cataract (HR, 0.94; CI, 0.76-1.17) (Table 2).”
Quoted verbatim from Age-related cataract in a randomized trial of vitamins E and C in men.. - Study
- RCT
- Dose
- 500 mg synthetic ascorbic acid daily versus placebo
- Population
- 11,545 apparently healthy US male physicians aged 50 years or older without cataract at baseline, in a 2x2x2x2 factorial trial where vitamin E, multivitamin and beta-carotene were randomised independently of vitamin C
Effect 1.01 hazard ratio, 95% CI 0.89 to 1.14
Age-related cataract in a randomized trial of vitamins E and C in men.2010PMID:21060040Industry fundedPermalink
L-ascorbic acid — no detected effect on cortical cataract incidence
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“For subtypes, there were no significant effects of vitamin C on incidence of nuclear (HR, 1.01; CI, 0.89-1.14), cortical (HR, 1.10; CI, 0.92-1.31), or PSC cataract (HR, 0.94; CI, 0.76-1.17) (Table 2).”
Quoted verbatim from Age-related cataract in a randomized trial of vitamins E and C in men.. - Study
- RCT
- Dose
- 500 mg synthetic ascorbic acid daily versus placebo
- Population
- 11,545 apparently healthy US male physicians aged 50 years or older without cataract at baseline, in a 2x2x2x2 factorial trial where vitamin E, multivitamin and beta-carotene were randomised independently of vitamin C
Effect 1.1 hazard ratio, 95% CI 0.92 to 1.31
Age-related cataract in a randomized trial of vitamins E and C in men.2010PMID:21060040Industry fundedPermalink
L-ascorbic acid — no detected effect on posterior subcapsular cataract incidence
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“For subtypes, there were no significant effects of vitamin C on incidence of nuclear (HR, 1.01; CI, 0.89-1.14), cortical (HR, 1.10; CI, 0.92-1.31), or PSC cataract (HR, 0.94; CI, 0.76-1.17) (Table 2).”
Quoted verbatim from Age-related cataract in a randomized trial of vitamins E and C in men.. - Study
- RCT
- Dose
- 500 mg synthetic ascorbic acid daily versus placebo
- Population
- 11,545 apparently healthy US male physicians aged 50 years or older without cataract at baseline, in a 2x2x2x2 factorial trial where vitamin E, multivitamin and beta-carotene were randomised independently of vitamin C
Effect 0.94 hazard ratio, 95% CI 0.76 to 1.17
Age-related cataract in a randomized trial of vitamins E and C in men.2010PMID:21060040Industry fundedPermalink