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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

29,851–29,900 of 31,435, by identifier

7,8-epoxymelianol = protoglabretal
Direction not assertedBalancedRhea 80299
isomeliandiol + acetyl-CoA = 21-O-acetyl-isomeliandiol + CoA
Direction not assertedBalancedRhea 80303
21-O-acetyl-isomeliandiol + A = (21S)-21-acetoxyl-apo-melianone + AH2
Direction not assertedBalancedRhea 80307
(21S)-21-acetoxyl-apo-melianone + reduced [NADPH--hemoprotein reductase] + O2 = luvungin A + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Direction not assertedBalance undeterminableRhea 80311
(21S)-21-acetoxyl-apo-melianone + reduced [NADPH--hemoprotein reductase] + O2 = (21S)-21-acetyl-1-hydroxy-apo-melianone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Direction not assertedBalance undeterminableRhea 80315
luvungin A + reduced [NADPH--hemoprotein reductase] + O2 = (1S)-1-hydroxy-luvungin A + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Direction not assertedBalance undeterminable

Rhea 80319

(1S)-1-hydroxy-luvungin A + acetyl-CoA = (1S)-1-acetoxy-luvungin A + CoA

Direction not assertedBalancedRhea 80323

(21S)-21-acetyl-1-hydroxy-apo-melianone + acetyl-CoA = epi-neemfruitin B + acetate + CoA + H(+)

Direction not assertedBalancedRhea 80327

(1S)-1-acetoxy-luvungin A + acetyl-CoA = (1S)-1,7-diacetoxy-luvungin A + CoA

Direction not assertedBalancedRhea 80331

epi-neemfruitin B + acetyl-CoA = 7-acetyl-epi-neemfruitin B + CoA

Direction not assertedBalancedRhea 80335

(1S)-1,7-diacetoxy-luvungin A + AH2 + H2O = (1R,2R,3S,8R,10R,11R,15S,16S)-3-(acetyloxy)-15-[(4R)-4-[(2S)-3,3-dimethyloxiran-2-yl]-1,4-dihydroxybutan-2-yl]-2,7,7,11,16-pentamethyl-5-oxo-6-oxatetracyclo[9.7.0.0(2,8).0(12,16)]octadec-12-en-10-yl acetate + acetate + A + H(+)

Direction not assertedBalancedRhea 80339

7-acetyl-epi-neemfruitin B + AH2 + H2O = (1S,3bR,4R,5aR,9aR,9bR,11aS)-1-[(4R)-5-[(2S)-3,3-dimethyloxiran-2-yl]-1,4-dihydroxybutan-2-yl]-3b,6,6,9a,11a-pentamethyl-7-oxo-1H,2H,3bH,4H,5H,5aH,6H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-4-yl acetate + acetate + A + H(+)

Direction not assertedBalancedRhea 80343

(1R,2R,3S,8R,10R,11R,15S,16S)-3-(acetyloxy)-15-[(4R)-4-[(2S)-3,3-dimethyloxiran-2-yl]-1,4-dihydroxybutan-2-yl]-2,7,7,11,16-pentamethyl-5-oxo-6-oxatetracyclo[9.7.0.0(2,8).0(12,16)]octadec-12-en-10-yl acetate + reduced [NADPH--hemoprotein reductase] + O2 = (1R,2R,3S,8R,10R,11R,15S,16S)-3-(acetyloxy)-15-(1-hydroxy-4-oxobutan-2-yl)-2,7,7,11,16-pentamethyl-5-oxo-6-oxatetracyclo[9.7.0.0(2,8).0(12,16)]octadec-12-en-10-yl acetate + 2-methylpropanoate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)

Direction not assertedBalance undeterminableRhea 80347

(1S,3bR,4R,5aR,9aR,9bR,11aS)-1-[(4R)-5-[(2S)-3,3-dimethyloxiran-2-yl]-1,4-dihydroxybutan-2-yl]-3b,6,6,9a,11a-pentamethyl-7-oxo-1H,2H,3bH,4H,5H,5aH,6H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-4-yl acetate + reduced [NADPH--hemoprotein reductase] + O2 = (1S,3bR,4R,5aR,9aR,9bR,11aS)-1-(1-hydroxy-4-oxobutan-2-yl)-3b,6,6,9a,11a-pentamethyl-7-oxo-1H,2H,3bH,4H,5H,5aH,6H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-4-yl acetate + 2-methylpropanoate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)

Direction not assertedBalance undeterminableRhea 80351

(1R,2R,3S,8R,10R,11R,15S,16S)-3-(acetyloxy)-15-(1-hydroxy-4-oxobutan-2-yl)-2,7,7,11,16-pentamethyl-5-oxo-6-oxatetracyclo[9.7.0.0(2,8).0(12,16)]octadec-12-en-10-yl acetate + 2-oxoglutarate + O2 = kihadalactone A + succinate + CO2 + 2 H2O

Direction not assertedBalancedRhea 80355

4-nitrotoluene + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = 4-nitrobenzyl alcohol + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O

Direction not assertedBalance undeterminableRhea 80359

4-nitrobenzaldehyde + NAD(+) + H2O = 4-nitrobenzoate + NADH + 2 H(+)

Direction not assertedBalancedRhea 80363

3-nitrobenzaldehyde + NAD(+) + H2O = 3-nitrobenzoate + NADH + 2 H(+)

Direction not assertedBalancedRhea 80367

4-methylbenzaldehyde + NAD(+) + H2O = 4-methylbenzoate + NADH + 2 H(+)

Direction not assertedBalancedRhea 80371

3-methylbenzaldehyde + NAD(+) + H2O = 3-methylbenzoate + NADH + 2 H(+)

Direction not assertedBalancedRhea 80375

4-nitrobenzyl alcohol + O2 = 4-nitrobenzaldehyde + H2O2

Direction not assertedBalancedRhea 80379

benzyl alcohol + O2 = benzaldehyde + H2O2

Direction not assertedBalancedRhea 80383

(1S,3bR,4R,5aR,9aR,9bR,11aS)-1-(1-hydroxy-4-oxobutan-2-yl)-3b,6,6,9a,11a-pentamethyl-7-oxo-1H,2H,3bH,4H,5H,5aH,6H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-4-yl acetate + 2-oxoglutarate + O2 = azadirone + succinate + CO2 + 2 H2O

Direction not assertedBalancedRhea 80387

(2E)-geranyl diphosphate = camphene + diphosphate

Direction not assertedBalancedRhea 80391

(2E)-geranyl diphosphate = isoterpinolene + diphosphate

Direction not assertedBalancedRhea 80395

(2E,6E)-farnesyl diphosphate + H2O = palustrol + diphosphate

Direction not assertedBalancedRhea 80399

(2E,6E)-farnesyl diphosphate + H2O = selina-6-en-4-ol + diphosphate

Direction not assertedBalancedRhea 80403

(2E,6E)-farnesyl diphosphate + H2O = gamma-eudesmol + diphosphate

Direction not assertedBalancedRhea 80407

L-tryptophyl-tRNA(Trp) + L-arginyl-tRNA(Arg) = cyclo(L-arginyl-L-tryptophyl) + tRNA(Trp) + tRNA(Arg) + H(+)

Direction not assertedBalance undeterminableRhea 80411

L-aspartyl-tRNA(Asp) + L-arginyl-tRNA(Arg) = cyclo(L-arginyl-L-aspartyl) + tRNA(Asp) + tRNA(Arg) + 2 H(+)

Direction not assertedBalance undeterminableRhea 80415

L-glutamyl-tRNA(Glu) + L-arginyl-tRNA(Arg) = cyclo(L-arginyl-L-glutamyl) + tRNA(Glu) + tRNA(Arg) + 2 H(+)

Direction not assertedBalance undeterminableRhea 80419

L-prolyl-tRNA(Pro) + L-arginyl-tRNA(Arg) = cyclo(L-arginyl-L-prolyl) + tRNA(Pro) + tRNA(Arg) + 2 H(+)

Direction not assertedBalance undeterminableRhea 80423

L-arginyl-tRNA(Arg) + L-leucyl-tRNA(Leu) = cyclo(L-arginyl-L-leucyl) + tRNA(Arg) + tRNA(Leu) + 2 H(+)

Direction not assertedBalance undeterminableRhea 80427

3-nitrobenzyl alcohol + O2 = 3-nitrobenzaldehyde + H2O2

Direction not assertedBalancedRhea 80431

4-methylbenzyl alcohol + O2 = 4-methylbenzaldehyde + H2O2

Direction not assertedBalancedRhea 80435

3-methylbenzyl alcohol + O2 = 3-methylbenzaldehyde + H2O2

Direction not assertedBalancedRhea 80439

2-methylbenzyl alcohol + O2 = 2-methylbenzaldehyde + H2O2

Direction not assertedBalancedRhea 80443

3-hydroxybenzyl alcohol + O2 = 3-hydroxybenzaldehyde + H2O2

Direction not assertedBalancedRhea 80447

salicyl alcohol + O2 = salicylaldehyde + H2O2

Direction not assertedBalancedRhea 80451

2,4-dimethylbenzyl alcohol + O2 = 2,4-dimethylbenzaldehyde + H2O2

Direction not assertedBalancedRhea 80455

3,4-dimethylbenzyl alcohol + O2 = 3,4-dimethylbenzaldehyde + H2O2

Direction not assertedBalancedRhea 80459

3,5-dimethylbenzyl alcohol + O2 = 3,5-dimethylbenzaldehyde + H2O2

Direction not assertedBalancedRhea 80463

4-ethylbenzyl alcohol + O2 = 4-ethylbenzaldehyde + H2O2

Direction not assertedBalancedRhea 80467

2-hydroxylamino-4,6-dinitrotoluene + UDP-alpha-D-glucose = 2-hydroxylamino-4,6-dinitrotoluene-O-beta-D-glucoside + UDP + H(+)

Direction not assertedBalancedRhea 80471

2-hydroxylamino-4,6-dinitrotoluene + UDP-alpha-D-glucose = 2-hydroxylamino-4,6-dinitrotoluene-3C-beta-D-glucoside + UDP + H(+)

Direction not assertedBalancedRhea 80475

4-hydroxylamino-2,6-dinitrotoluene + UDP-alpha-D-glucose = 4-hydroxylamino-2,6-dinitrotoluene-O-beta-D-glucoside + UDP + H(+)

Direction not assertedBalancedRhea 80479

4-hydroxylamino-2,6-dinitrotoluene + UDP-alpha-D-glucose = 4-hydroxylamino-2,6-dinitrotoluene-3C-beta-D-glucoside + UDP + H(+)

Direction not assertedBalancedRhea 80483

2-amino-4,6-dinitrotoluene + UDP-alpha-D-glucose = 2-amino-4,6-dinitrotoluene beta-D-glucoside + UDP + H(+)

Direction not assertedBalancedRhea 80487

4-amino-2,6-dinitrotoluene + UDP-alpha-D-glucose = 4-amino-2,6-dinitrotoluene beta-D-glucoside + UDP + H(+)

Direction not assertedBalancedRhea 80491

4-amino-2,6-dinitrotoluene + 2 NADPH + 2 H(+) = 4-amino-2-hydroxylamino-6-nitrotoluene + 2 NADP(+) + H2O

Direction not assertedBalancedRhea 80495

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