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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

29,351–29,400 of 31,435, by identifier

guanosine(34) in tRNA(Tyr) + queuine = queuosine(34) in tRNA(Tyr) + guanine
Direction not assertedBalancedRhea 78299
guanosine(34) in tRNA(Asp) + queuine = queuosine(34) in tRNA(Asp) + guanine
Direction not assertedBalancedRhea 78303
2-(trimethylamino)-vinylphosphonate + 2-oxoglutarate + O2 = methyldehydrofosmidomycin + formaldehyde + succinate + CO2
Direction not assertedBalancedRhea 78307
dAMP + dATP = 2 dADP
Direction not assertedBalancedRhea 78311
ADP + ATP = adenosine 5'-tetraphosphate + AMP
Direction not assertedBalancedRhea 78315
a III(4)-a-Fuc-Lc4Cer(d18:1(4E)) + GDP-beta-L-fucose = a lactoside IV(2),III(4)-a-[Fuc]2-Lc4Cer(d18:1(4E)) + GDP + H(+)
Direction not assertedBalance undeterminableRhea 78319
glyoxylate + L-glutamine = 2-oxoglutaramate + glycine

Direction not assertedBalancedRhea 78323

L-erythrulose + D-erythrose 4-phosphate = glycolaldehyde + beta-D-fructose 6-phosphate

Direction not assertedBalancedRhea 78327

UTP + UMP = 2 UDP

Direction not assertedBalancedRhea 78331

UTP + ATP = 2',3'-cUAMP + 2 diphosphate

Direction not assertedBalancedRhea 78335

2',3'-cGAMP + H2O = 5'-pGpA(2'-5') + H(+)

Left to rightBalancedRhea 78339

5'-pGpA(2'-5') + H2O = 5'-GpA(2'-5') + phosphate

Left to rightBalancedRhea 78343

N-acyl-1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)

Direction not assertedBalance undeterminableRhea 78347

a 1,2-diacyl-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phospho-L-serine

Left to rightBalance undeterminableRhea 78351

a 1,2-diacyl-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine = a 2-acyl-sn-glycero-3-phospho-L-serine + 1-O-acyl-N-(acetyl)-sphing-4-enine

Left to rightBalance undeterminableRhea 78355

a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine = 2-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-O-acyl-N-(acetyl)-sphing-4-enine

Left to rightBalance undeterminableRhea 78359

a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine = 1-O-acyl-N-(acetyl)-sphing-4-enine + 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)

Left to rightBalance undeterminableRhea 78363

N(tau)-methylhistamine + O2 + H2O = 1-methylimidazole-4-acetaldehyde + H2O2 + NH4(+)

Left to rightBalancedRhea 78367

S-nitrosoglutathione + NADH + H(+) = S-(hydroxysulfenamide)glutathione + NAD(+)

Left to rightBalancedRhea 78371

S-nitroso-CoA + NADPH + H(+) = sulfinamide-CoA + NADP(+)

Left to rightBalancedRhea 78375

S-nitroso-CoA + L-cysteinyl-[protein] = S-nitroso-L-cysteinyl-[protein] + CoA

Left to rightBalance undeterminableRhea 78379

L-cysteinyl-[SCAN] + S-nitroso-CoA = S-nitroso-L-cysteinyl-[SCAN] + CoA

Left to rightBalance undeterminableRhea 78383

S-nitroso-L-cysteinyl-[SCAN] + L-cysteinyl-[protein] = L-cysteinyl-[SCAN] + S-nitroso-L-cysteinyl-[protein]

Left to rightBalance undeterminableRhea 78387

D-mannose(out) = D-mannose(in)

Direction not assertedBalancedTransportRhea 78391

bilirubin IXbeta + NADP(+) = biliverdin IXbeta + NADPH + H(+)

Right to leftBalancedRhea 78395

(2E,6E,10E,14E)-geranylfarnesyl diphosphate = astellifadiene + diphosphate

Direction not assertedBalancedRhea 78399

(2E,6E,10E)-geranylgeranyl diphosphate + H2O = (+)-penichrysol + diphosphate

Direction not assertedBalancedRhea 78403

sesterfisherol + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = sesterfisherate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)

Direction not assertedBalance undeterminableRhea 78407

carbendazim + H2O = 2-aminobenzimidazole + methanol + CO2

Direction not assertedBalancedRhea 78411

carbendazim + H2O = N-(1H-1,3-benzodiazol-2-yl)carbamate + methanol + H(+)

Direction not assertedBalancedRhea 78415

N-(1H-1,3-benzodiazol-2-yl)carbamate + H(+) = 2-aminobenzimidazole + CO2

Direction not assertedBalancedRhea 78419

D-glucosamine(out) = D-glucosamine(in)

Direction not assertedBalancedTransportRhea 78423

D-xylose(out) = D-xylose(in)

Direction not assertedBalancedTransportRhea 78427

1-O-alkyl-2-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1-O-alkyl-2,3-diacyl-sn-glycerol + a 2-acyl-sn-glycero-3-phosphocholine

Left to rightBalance undeterminableRhea 78431

1-O-alkyl-2-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1-O-alkyl-2,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine

Left to rightBalance undeterminableRhea 78435

a 2-acylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a 1,2-diacylglycerol + a 1-acyl-sn-glycero-3-phosphocholine

Left to rightBalance undeterminableRhea 78439

a 2-acylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a 1,2-diacylglycerol + a 2-acyl-sn-glycero-3-phosphocholine

Left to rightBalance undeterminableRhea 78443

a globoside Gb3Cer (d18:1(4E)) + H2O = a lysoGb3(d18:1(4E)) + a fatty acid

Left to rightBalance undeterminableRhea 78447

a globoside Gb3Cer + H2O = a lysoGb3 + a fatty acid

Left to rightBalance undeterminableRhea 78451

an N-acyl-sphingoid base + H2O = a sphingoid base + a fatty acid

Direction not assertedBalance undeterminableRhea 78455

a [peptide](out) + ATP + H2O = a [peptide](in) + ADP + phosphate + H(+)

Direction not assertedBalance undeterminableTransportRhea 78459

a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-alpha-D-galactose = an isogloboside iGb3Cer + UDP + H(+)

Direction not assertedBalance undeterminableRhea 78463

a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + CMP-N-acetyl-beta-neuraminate = a ganglioside GM3 + CMP + H(+)

Direction not assertedBalance undeterminableRhea 78467

a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)

Left to rightBalance undeterminableRhea 78471

a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)

Left to rightBalance undeterminableRhea 78475

a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)

Left to rightBalance undeterminableRhea 78479

2-amino-4-phosphonobutanoate + CTP = CMP-5'-(3-amino-3-carboxypropyl)phosphonate + diphosphate

Direction not assertedBalancedRhea 78483

CMP-5'-(3-amino-3-carboxypropyl)phosphonate + H(+) = CMP-5'-(3-aminopropyl)phosphonate + CO2

Direction not assertedBalancedRhea 78487

CMP-5'-(3-aminopropyl)phosphonate + NADPH + O2 = CMP-5'-(N-hydroxy-3-aminopropyl)phosphonate + NADP(+) + H2O

Direction not assertedBalancedRhea 78491

CMP-5'-(N-hydroxy-3-aminopropyl)phosphonate + acetyl-CoA = CMP-5'-(N-acetyl-N-hydroxy-3-aminopropyl)phosphonate + CoA

Direction not assertedBalancedRhea 78495

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