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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
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Reactions
Reach

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Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

28,851–28,900 of 31,435, by identifier

cob(I)alamin + S-adenosyl-L-methionine = methylcob(III)alamin + S-adenosyl-L-homocysteine
Direction not assertedBalancedRhea 76295
L-cystine(out) + L-aspartate(in) = L-cystine(in) + L-aspartate(out)
Direction not assertedBalancedTransportRhea 76299
L-cystine(out) = L-cystine(in)
Direction not assertedBalancedTransportRhea 76303
L-aspartate(in) + L-glutamate(out) = L-aspartate(out) + L-glutamate(in)
Direction not assertedBalancedTransportRhea 76307
L-aspartate(in) + L-glutamine(out) = L-aspartate(out) + L-glutamine(in)
Direction not assertedBalancedTransportRhea 76311
L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L-methionine(in)
Direction not assertedBalancedTransportRhea 76315

L-leucine(out) + L-aspartate(in) = L-leucine(in) + L-aspartate(out)

Direction not assertedBalancedTransportRhea 76319

L-valine(out) + L-aspartate(in) = L-valine(in) + L-aspartate(out)

Direction not assertedBalancedTransportRhea 76323

L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)

Direction not assertedBalancedTransportRhea 76327

L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)

Direction not assertedBalancedTransportRhea 76331

L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)

Direction not assertedBalancedTransportRhea 76335

urate(out) + 2 Na(+)(out) = urate(in) + 2 Na(+)(in)

Left to rightBalancedTransportRhea 76339

(2S)-2-isopropylmalate(in) + sulfate(out) = (2S)-2-isopropylmalate(out) + sulfate(in)

Direction not assertedBalancedTransportRhea 76343

(2R,3S)-3-isopropylmalate(in) + sulfate(out) = (2R,3S)-3-isopropylmalate(out) + sulfate(in)

Direction not assertedBalancedTransportRhea 76347

oxaloacetate(in) + sulfate(out) = oxaloacetate(out) + sulfate(in)

Direction not assertedBalancedTransportRhea 76351

N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanine(out) + n H(+)(out) = N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanine(in) + n H(+)(in)

Left to rightBalance undeterminableTransportRhea 76355

N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimelate(out) + n H(+)(out) = N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimelate(in) + n H(+)(in)

Direction not assertedBalance undeterminableTransportRhea 76359

N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine(out) + n H(+)(out) = N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine(in) + n H(+)(in)

Direction not assertedBalance undeterminableTransportRhea 76363

N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramate(out) + n H(+)(out) = N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramate(in) + n H(+)(in)

Direction not assertedBalance undeterminableTransportRhea 76367

N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(out) + n H(+)(out) = N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(in) + n H(+)(in)

Left to rightBalance undeterminableTransportRhea 76371

N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(out) + 3 H(+)(out) = N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(in) + 3 H(+)(in)

Left to rightBalancedTransportRhea 76375

L-histidine(out) + n H(+)(out) = L-histidine(in) + n H(+)(in)

Left to rightBalance undeterminableTransportRhea 76379

carnosine(out) + n H(+)(out) = carnosine(in) + n H(+)(in)

Left to rightBalance undeterminableTransportRhea 76383

N(6)-hydroxy-L-lysine + L-glutamate + ATP = 1-L-glutamo-2-N(6-)L-lysinohydrazine + AMP + diphosphate + 2 H(+)

Direction not assertedBalancedRhea 76387

glycylglycylglycine(out) + n H(+)(out) = glycylglycylglycine(in) + n H(+)(in)

Left to rightBalance undeterminableTransportRhea 76391

N(6)-hydroxy-L-lysine + L-glutamate + ATP = O-glutamyl-N(6)-hydroxy-L-lysine + AMP + diphosphate

Direction not assertedBalancedRhea 76395

O-glutamyl-N(6)-hydroxy-L-lysine = 1-L-glutamo-2-N(6-)L-lysinohydrazine + 2 H(+)

Direction not assertedBalancedRhea 76399

O-glutamyl-N(6)-hydroxy-L-lysine = (2S)-2-ammonio-6-[(2S)-2-ammonio-4-carboxylato-N-hydroxybutanamido]hexanoate

Direction not assertedBalancedRhea 76403

Xaa-L-Pro dipeptide + H2O = an L-alpha-amino acid + L-proline

Direction not assertedBalance undeterminableRhea 76407

2',3'-cGAMP(out) + n H(+)(out) = 2',3'-cGAMP(in) + n H(+)(in)

Left to rightBalance undeterminableTransportRhea 76411

3',3'-cGAMP(out) + n H(+)(out) = 3',3'-cGAMP(in) + n H(+)(in)

Left to rightBalance undeterminableTransportRhea 76415

2-hydroxymethyl-3-pentylphenol + reduced [NADPH--hemoprotein reductase] + O2 = (8S)-annullatin E + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 76419

(8S)-annullatin E + dimethylallyl diphosphate = (8S)-annullatin J + diphosphate

Direction not assertedBalancedRhea 76423

(2R,9S)-annullatin H + A = (2R)-annullatin F + AH2

Direction not assertedBalancedRhea 76427

Na(+)(out) + NH4(+)(in) = Na(+)(in) + NH4(+)(out)

Left to rightBalancedTransportRhea 76431

(2S,9S)-annullatin H + 2 A = (2S,9S)-annullatin D + 2 AH2

Direction not assertedBalancedRhea 76435

19-hydroxy-11-deoxycorticosterone + 2 reduced [adrenodoxin] + O2 + 2 H(+) = 19-oxo-11-deoxycorticosterone + 2 oxidized [adrenodoxin] + 2 H2O

Direction not assertedBalance undeterminableRhea 76439

choline(out) + n Na(+)(out) = choline(in) + n Na(+)(in)

Direction not assertedBalance undeterminableTransportRhea 76443

L-aspartate + L-methionine + ATP = L-aspartyl-L-methionine + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 76447

(E)-4-coumaroyl alcohol + A = (E)-4-coumaraldehyde + AH2

Direction not assertedBalancedRhea 76451

(E)-coniferol + A = (E)-coniferaldehyde + AH2

Direction not assertedBalancedRhea 76455

(E)-sinapyl alcohol + A = (E)-sinapaldehyde + AH2

Direction not assertedBalancedRhea 76459

4-O-(beta-D-glucosyl)-(E)-coniferol + A = 4-O-(beta-D-glucosyl)-4-(E)-coniferyl aldehyde + AH2

Direction not assertedBalancedRhea 76463

tetracenomycin B2 + 2 NADPH + 2 O2 + 2 H(+) = 8-demethyltetracenomycin C + 2 NADP(+) + H2O

Direction not assertedBalancedRhea 76467

cob(III)alamin + AH2 = cob(I)alamin + A + 2 H(+)

Direction not assertedBalancedRhea 76471

hexadecan-1-ol + O2 = hexadecanal + H2O2

Direction not assertedBalancedRhea 76475

hexadecane-1,16-diol + O2 = hydroxyhexadecanal + H2O2

Direction not assertedBalancedRhea 76479

sphing-4-enine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = sphinga-4E,14Z-dienine + 2 Fe(III)-[cytochrome b5] + 2 H2O

Left to rightBalance undeterminableRhea 76483

N-acyl-1-deoxysphinganine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = N-acyl-1-deoxysphing-14Z-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O

Left to rightBalance undeterminableRhea 76487

(E)-ferulate + H2O = vanillin + acetate

Direction not assertedBalancedRhea 76491

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