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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

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Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

28,801–28,850 of 31,435, by identifier

(11R)-19-oxocarlactone + reduced [NADPH--hemoprotein reductase] + O2 = (11R)-carlactonoate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)
Direction not assertedBalance undeterminableRhea 76095
xanthurenate(out) + a dicarboxylate(in) = xanthurenate(in) + a dicarboxylate(out)
Direction not assertedBalance undeterminableTransportRhea 76099
(11R)-carlactonoate + S-adenosyl-L-methionine = (11R)-methyl carlactonoate + S-adenosyl-L-homocysteine
Direction not assertedBalancedRhea 76103
(11R)-methyl carlactonoate + 2-oxoglutarate + O2 = (11R)-hydroxymethyl carlactonoate + succinate + CO2
Direction not assertedBalancedRhea 76107
4-methylumbelliferone beta-D-glucuronate + H2O = 4-methylumbelliferone + D-glucuronate
Direction not assertedBalancedRhea 76111
thebaine + 2-oxoglutarate + O2 = 6-O-demethylthebaine + formaldehyde + succinate + CO2 + H(+)
Direction not asserted

Balanced

Rhea 76115

prostaglandin F2alpha(out) + a dicarboxylate(in) = prostaglandin F2alpha(in) + a dicarboxylate(out)

Direction not assertedBalance undeterminableTransportRhea 76119

prostaglandin E2(out) + a dicarboxylate(in) = prostaglandin E2(in) + a dicarboxylate(out)

Direction not assertedBalance undeterminableTransportRhea 76123

3',5'-cyclic AMP(out) + a dicarboxylate(in) = 3',5'-cyclic AMP(in) + a dicarboxylate(out)

Direction not assertedBalance undeterminableTransportRhea 76127

3',5'-cyclic GMP(out) + a dicarboxylate(in) = 3',5'-cyclic GMP(in) + a dicarboxylate(out)

Direction not assertedBalance undeterminableTransportRhea 76131

urate(out) + a dicarboxylate(in) = urate(in) + a dicarboxylate(out)

Direction not assertedBalance undeterminableTransportRhea 76135

D-gluconate(in) = D-gluconate(out)

Direction not assertedBalancedTransportRhea 76139

picrinine + S-adenosyl-L-methionine = ervincine + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 76143

perivine + S-adenosyl-L-methionine = vobasine + S-adenosyl-L-homocysteine + 2 H(+)

Direction not assertedBalancedRhea 76147

21-hydroxyprogesterone + 2 reduced [adrenodoxin] + O2 + 2 H(+) = 18-hydroxy-11-deoxycorticosterone + 2 oxidized [adrenodoxin] + H2O

Left to rightBalance undeterminableRhea 76151

21-hydroxyprogesterone + 2 reduced [adrenodoxin] + O2 + 2 H(+) = 19-hydroxy-11-deoxycorticosterone + 2 oxidized [adrenodoxin] + H2O

Direction not assertedBalance undeterminableRhea 76155

fluoride(in) = fluoride(out)

Right to leftBalancedTransportRhea 76159

11-deoxycortisol + 2 reduced [adrenodoxin] + O2 + 2 H(+) = 18-hydroxy-11-deoxycortisol + 2 oxidized [adrenodoxin] + H2O

Direction not assertedBalance undeterminableRhea 76163

glycyl-L-leucine(out) + 2 H(+)(out) = glycyl-L-leucine(in) + 2 H(+)(in)

Left to rightBalancedTransportRhea 76167

glycyl-L-lysine(out) + 2 H(+)(out) = glycyl-L-lysine(in) + 2 H(+)(in)

Left to rightBalancedTransportRhea 76171

glycyl-L-glutamate(out) + 3 H(+)(out) = glycyl-L-glutamate(in) + 3 H(+)(in)

Left to rightBalancedTransportRhea 76175

a dipeptide(out) + 2 H(+)(out) = a dipeptide(in) + 2 H(+)(in)

Left to rightBalance undeterminableTransportRhea 76179

L-alanyl-L-alanine(out) + 2 H(+)(out) = L-alanyl-L-alanine(in) + 2 H(+)(in)

Left to rightBalancedTransportRhea 76183

an L-amino acid tripeptide(out) + 2 H(+)(out) = an L-amino acid tripeptide(in) + 2 H(+)(in)

Left to rightBalance undeterminableTransportRhea 76187

carnosine(out) + 2 H(+)(out) = carnosine(in) + 2 H(+)(in)

Left to rightBalancedTransportRhea 76191

UDP-alpha-D-glucose(in) = UDP-alpha-D-glucose(out)

Direction not assertedBalancedTransportRhea 76195

oxalate(in) = oxalate(out)

Direction not assertedBalancedTransportRhea 76199

pyridoxine(out) + n H(+)(out) = pyridoxine(in) + n H(+)(in)

Direction not assertedBalance undeterminableTransportRhea 76203

3',5'-cyclic GMP(in) = 3',5'-cyclic GMP(out)

Direction not assertedBalancedTransportRhea 76207

GMP(in) = GMP(out)

Direction not assertedBalancedTransportRhea 76211

2'-deoxyguanosine(in) = 2'-deoxyguanosine(out)

Direction not assertedBalancedTransportRhea 76215

GDP(in) = GDP(out)

Direction not assertedBalancedTransportRhea 76219

3',5'-cyclic AMP(in) = 3',5'-cyclic AMP(out)

Direction not assertedBalancedTransportRhea 76223

(Z)-(indol-3-yl)-N-(sulfonatooxy)methanimidothioate = (indol-3-yl)acetonitrile + sulfur + sulfate

Direction not assertedBalancedRhea 76227

2-oxoglutarate(in) = 2-oxoglutarate(out)

Direction not assertedBalancedTransportRhea 76231

a tRNA with a 3' CCA end + 2 CTP + ATP = a tRNA with a 3' CCACCA end + 3 diphosphate

Left to rightBalance undeterminableRhea 76235

L-tyrosyl-[protein] + L-ascorbate + L-lysyl-[protein] + 2 O2 = glycyl-[protein] + (S)-2-amino-6-oxohexanoyl-[protein] + 4-aminobenzoate + L-dehydroascorbate + 2 H2O + 2 H(+)

Direction not assertedBalance undeterminableRhea 76239

a glycyl-glycyl-[protein] + H2O = N-terminal glycyl-[protein] + [protein]-C-terminal glycine

Direction not assertedBalance undeterminableRhea 76243

ergothioneine(out) + ATP + H2O = ergothioneine(in) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 76247

glutarate(in) = glutarate(out)

Direction not assertedBalancedTransportRhea 76251

a 5'-end 2'-deoxyribose-2'-deoxyribonucleotide-DNA = (2E,4S)-4-hydroxypenten-2-al-5-phosphate + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)

Left to rightBalance undeterminableRhea 76255

taurine(in) + H(+)(in) = taurine(out) + H(+)(out)

Direction not assertedBalancedTransportRhea 76259

ergothioneine(in) = ergothioneine(out)

Right to leftBalancedTransportRhea 76263

carnosine(in) = carnosine(out)

Right to leftBalancedTransportRhea 76267

N,N-dimethylglycine(in) = N,N-dimethylglycine(out)

Right to leftBalancedTransportRhea 76271

uracil(out) + Na(+)(out) = uracil(in) + Na(+)(in)

Direction not assertedBalancedTransportRhea 76275

hypoxanthine(out) + Na(+)(out) = hypoxanthine(in) + Na(+)(in)

Direction not assertedBalancedTransportRhea 76279

guanine(out) + Na(+)(out) = guanine(in) + Na(+)(in)

Direction not assertedBalancedTransportRhea 76283

thymine(out) + Na(+)(out) = thymine(in) + Na(+)(in)

Direction not assertedBalancedTransportRhea 76287

xanthine(out) + Na(+)(out) = xanthine(in) + Na(+)(in)

Direction not assertedBalancedTransportRhea 76291

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