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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

28,651–28,700 of 31,435, by identifier

dehydroepiandrosterone 3-sulfate(out) + n H(+)(out) = dehydroepiandrosterone 3-sulfate(in) + n H(+)(in)
Direction not assertedBalance undeterminableTransportRhea 75487
25-hydroxyvitamin D3 sulfate(out) + n H(+)(out) = 25-hydroxyvitamin D3 sulfate(in) + n H(+)(in)
Direction not assertedBalance undeterminableTransportRhea 75491
pregnenolone sulfate(out) + n H(+)(out) = pregnenolone sulfate(in) + n H(+)(in)
Direction not assertedBalance undeterminableTransportRhea 75495
cholate(out) + n H(+)(out) = cholate(in) + n H(+)(in)
Direction not assertedBalance undeterminableTransportRhea 75499
glycocholate(out) + n H(+)(out) = glycocholate(in) + n H(+)(in)
Direction not assertedBalance undeterminableTransportRhea 75503
taurocholate(out) + n H(+)(out) = taurocholate(in) + n H(+)(in)
Direction not asserted

Balance undeterminable

Transport

Rhea 75507

S-benzyl-L-cysteine + acetyl-CoA = N-acetyl-S-benzyl-L-cysteine + CoA + H(+)

Direction not assertedBalancedRhea 75511

N-acetyl-L-cysteine + H2O = L-cysteine + acetate

Direction not assertedBalancedRhea 75515

N-acetyl-S-benzyl-L-cysteine + FMNH2 + O2 = (R)-N-acetyl-S-benzyl-L-cysteine sulfoxide + FMN + H2O + H(+)

Direction not assertedBalancedRhea 75519

S-methyl-L-cysteine + acetyl-CoA = N-acetyl-S-methyl-L-cysteine + CoA + H(+)

Direction not assertedBalancedRhea 75523

(R)-N-acetyl-S-benzyl-L-cysteine sulfoxide + FMNH2 + O2 = N-acetyl-S-hydroxy-L-cysteine + benzaldehyde + FMN + H2O + H(+)

Direction not assertedBalancedRhea 75527

N-acetyl-S-hydroxy-L-cysteine + AH2 = N-acetyl-L-cysteine + A + H2O

Direction not assertedBalancedRhea 75531

N-acetyl-S-methyl-L-cysteine + FMNH2 + O2 = (R)-N-acetyl-S-methyl-L-cysteine sulfoxide + FMN + H2O + H(+)

Direction not assertedBalancedRhea 75535

(2E)-decenoate + holo-[ACP] + ATP = (2E)-decenoyl-[ACP] + AMP + diphosphate

Direction not assertedBalance undeterminableRhea 75539

(3R)-3-[(carboxylmethyl)amino]decanoate + holo-[ACP] + H(+) = (2E)-decenoyl-[ACP] + glycine + H2O

Direction not assertedBalance undeterminableRhea 75543

2 (3R)-3-isocyanylbutanoyl-[ACP] + L-lysine + ATP + 2 NADPH = (2S)-2,6-bis[(3R)-3-isocyanobutanamido]hexan-1-ol + 2 holo-[ACP] + AMP + diphosphate + 2 NADP(+)

Direction not assertedBalance undeterminableRhea 75547

2 a (3R)-3-isocyanyl-fatty acyl-[ACP] + L-lysine + ATP + 2 NADPH = an isonitrile lipopeptide + 2 holo-[ACP] + AMP + diphosphate + 2 NADP(+)

Direction not assertedBalance undeterminableRhea 75551

(-)-cyatha-3,12-diene + reduced [NADPH--hemoprotein reductase] + O2 = erinacol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 75555

erinacol + reduced [NADPH--hemoprotein reductase] + O2 = cyathadiol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 75559

cyathadiol + reduced [NADPH--hemoprotein reductase] + O2 = cyathatriol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 75563

cyathatriol + acetyl-CoA = 11-O-acetylcyathatriol + CoA

Direction not assertedBalancedRhea 75567

cyathin A3 + acetyl-CoA = 11-O-acetylcyathin A3 + CoA

Direction not assertedBalancedRhea 75571

11-O-acetylcyathatriol + A = 11-O-acetylcyathin A3 + AH2

Direction not assertedBalancedRhea 75575

cyathatriol + A = cyathin A3 + AH2

Direction not assertedBalancedRhea 75579

11-O-acetylcyathatriol + UDP-alpha-D-xylose = erinacine Q + UDP + H(+)

Direction not assertedBalancedRhea 75583

11-O-acetylcyathatriol + UDP-alpha-D-glucose = erinacine Q2 + UDP + H(+)

Direction not assertedBalancedRhea 75587

(9S)-hydroperoxy-(10E,12Z)-octadecadienoate = (11S)-hydroxy-(9S,10S)-epoxy-(12Z)-octadecenoate

Direction not assertedBalancedRhea 75591

(13S)-hydroperoxy-(9Z,11E)-octadecadienoate = 11-hydroxy-12,13-epoxy-(9Z)-octadecenoate

Direction not assertedBalancedRhea 75595

(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate = ectocarpin A + H2O

Direction not assertedBalancedRhea 75599

(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate = plasmodiophorol A

Direction not assertedBalancedRhea 75603

(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate = plasmodiophorol B

Direction not assertedBalancedRhea 75607

plasmodiophorol A + H2O = plasmodiophorol C

Direction not assertedBalancedRhea 75611

(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate = ectocarpin B + H2O

Direction not assertedBalancedRhea 75615

(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate = ectocarpin C

Direction not assertedBalancedRhea 75619

(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate = 14-oxo-15-hydroxy-(5Z,8Z,11Z,17Z)-eicosatetraenoate

Direction not assertedBalancedRhea 75623

(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + H2O = ectocarpin D

Direction not assertedBalancedRhea 75627

plasmodiophorol B + H2O = plasmodiophorol C

Direction not assertedBalancedRhea 75631

(9Z)-octadecenoate + O2 = 10-hydroperoxy-(8E)-octadecenoate

Direction not assertedBalancedRhea 75635

(8E,10R,12Z)-10-hydroperoxyoctadeca-8,12-dienoate = (12S,13R)-epoxy-(10R)-hydroxy-(8E)-octadecenoate

Direction not assertedBalancedRhea 75639

(9Z,12Z,15Z)-octadecatrienoate + O2 = (10R)-hydroperoxy-(8E,12Z,15Z)-octadecatrienoate

Direction not assertedBalancedRhea 75643

(9Z,12Z,15Z)-octadecatrienoate + O2 = (8R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate

Direction not assertedBalancedRhea 75647

(10R)-hydroperoxy-(8E,12Z,15Z)-octadecatrienoate = 12,13-epoxy-(10R)-hydroxy-(8E,15Z)-octadecadienoate

Direction not assertedBalancedRhea 75651

(9Z)-octadecenoate + O2 = (8R)-hydroperoxy-(9Z)-octadecenoate

Direction not assertedBalancedRhea 75655

(11Z,14Z)-eicosadienoate + O2 = 12-hydroperoxy-(10E,14Z)-eicosadienoate

Direction not assertedBalancedRhea 75659

12-hydroperoxy-(10E,14Z)-eicosadienoate = 10,11-epoxy-12-hydroxy-(14Z)-eicosenoate

Direction not assertedBalancedRhea 75663

(11Z,14Z,17Z)-eicosatrienoate + O2 = 12-hydroperoxy-(10E,14Z,17Z)-eicosatrienoate

Direction not assertedBalancedRhea 75667

12-hydroperoxy-(10E,14Z,17Z)-eicosatrienoate = 14,15-epoxy-12-hydroxy-(10E,17Z)-eicosadienoate

Direction not assertedBalancedRhea 75671

(13R)-hydroperoxy-(9Z,11E)-octadecadienoate = (12R,13R)-epoxy-(11S)-hydroxy-(9Z)-octadecenoate

Direction not assertedBalancedRhea 75675

(13S)-hydroperoxy-(9Z,11E)-octadecadienoate = (12R,13R)-epoxy-(11S)-hydroxy-(9Z)-octadecenoate

Direction not assertedBalancedRhea 75679

(12R,13S)-epoxy-(9Z)-octadecenoate + O2 = (12R,13S)-epoxy-(10R)-hydroperoxy-(8E)-octadecenoate

Direction not assertedBalancedRhea 75683

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