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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Reactions
Reach

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Organisms
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

28,701–28,750 of 31,435, by identifier

ATP(in) = ATP(out)
Left to rightBalancedTransportRhea 75687
2'-deoxyadenosine(in) = 2'-deoxyadenosine(out)
Direction not assertedBalancedTransportRhea 75691
2'-deoxycytidine(in) = 2'-deoxycytidine(out)
Direction not assertedBalancedTransportRhea 75695
2 glutathione + NAD(+) = glutathione disulfide + NADH + H(+)
Direction not assertedBalancedRhea 75699
12-hydroperoxy-(10E,14Z)-eicosadienoate = 14,15-epoxy-12-hydroxy-(10E)-eicosenoate
Direction not assertedBalancedRhea 75703
12-hydroperoxy-(10E,14Z,17Z)-eicosatrienoate = 10,11-epoxy-12-hydroxy-(14Z,17Z)-eicosadienoate
Direction not assertedBalancedRhea 75707
a rhodoquinone + succinate = a rhodoquinol + fumarate

Direction not assertedBalance undeterminableRhea 75711

CoA-disulfide + H2O = 4'-phosphopantetheinyl-CoA disulfide + adenosine 3',5'-bisphosphate + 2 H(+)

Direction not assertedBalancedRhea 75719

(9Z,12Z)-octadecadienoate + H2O = (10S)-hydroxy-(12Z)-octadecenoate

Direction not assertedBalancedRhea 75723

(10E,12Z)-octadecadienoate + H2O = (10S)-hydroxy-(12Z)-octadecenoate

Direction not assertedBalancedRhea 75727

(10S)-hydroxy-(12Z)-octadecenoate + NAD(+) = 10-oxo-(12Z)-octadecenoate + NADH + H(+)

Direction not assertedBalancedRhea 75731

10-oxo-(12Z)-octadecenoate = 10-oxo-(11E)-octadecenoate

Direction not assertedBalancedRhea 75735

10-oxo-(11E)-octadecenoate + NADH + H(+) = 10-oxooctadecanoate + NAD(+)

Direction not assertedBalancedRhea 75739

10-oxo-(11E)-octadecenoate + NADH + H(+) = 10-hydroxy-(11E)-octadecenoate + NAD(+)

Direction not assertedBalancedRhea 75743

10-oxooctadecanoate + NADH + H(+) = 10-hydroxyoctadecanoate + NAD(+)

Direction not assertedBalancedRhea 75747

(9Z)-octadecenoate + H2O = 10-hydroxyoctadecanoate

Direction not assertedBalancedRhea 75751

(10E)-octadecenoate + H2O = 10-hydroxyoctadecanoate

Direction not assertedBalancedRhea 75755

(9Z,11E)-octadecadienoate + H2O = 10-hydroxy-(11E)-octadecenoate

Direction not assertedBalancedRhea 75759

(9E,11E)-octadecadienoate + H2O = 10-hydroxy-(11E)-octadecenoate

Direction not assertedBalancedRhea 75763

(9Z)-hexadecenoate + H2O = 10-hydroxyhexadecanoate

Direction not assertedBalancedRhea 75767

(9Z,12Z,15Z)-octadecatrienoate + H2O = (10S)-hydroxy-(12Z,15Z)-octadecadienoate

Direction not assertedBalancedRhea 75771

(6Z,9Z,12Z)-octadecatrienoate + H2O = (10S)-hydroxy-(6Z,12Z)-octadecadienoate

Direction not assertedBalancedRhea 75775

(6Z,9Z,12Z,15Z)-octadecatetraenoate + H2O = (10S)-hydroxy-(6Z,12Z,15Z)-octadecatrienoate

Direction not assertedBalancedRhea 75779

ADP(in) = ADP(out)

Direction not assertedBalancedTransportRhea 75783

GTP(in) = GTP(out)

Direction not assertedBalancedTransportRhea 75787

(S)-lactate(out) + Na(+)(out) = (S)-lactate(in) + Na(+)(in)

Direction not assertedBalancedTransportRhea 75791

nicotinate(out) + Na(+)(out) = nicotinate(in) + Na(+)(in)

Direction not assertedBalancedTransportRhea 75795

pyruvate(out) + Na(+)(out) = pyruvate(in) + Na(+)(in)

Direction not assertedBalancedTransportRhea 75799

butanoate(out) + Na(+)(out) = butanoate(in) + Na(+)(in)

Direction not assertedBalancedTransportRhea 75803

propanoate(out) + Na(+)(out) = propanoate(in) + Na(+)(in)

Direction not assertedBalancedTransportRhea 75807

acetoacetate(out) + Na(+)(out) = acetoacetate(in) + Na(+)(in)

Direction not assertedBalancedTransportRhea 75811

K(+)(in) + ATP + H2O = K(+)(out) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 75815

(5Z,8Z)-octadecadienoate + O2 = (5S)-hydroperoxy-(6E,8Z)-octadecadienoate

Direction not assertedBalancedRhea 75819

(5S)-hydroxy-(6E,8Z)-octadecadienoate + reduced [NADH--hemoprotein reductase] + O2 = 5-oxo-(6E,8Z)-octadecadienoate + oxidized [NADH--hemoprotein reductase] + 2 H2O + H(+)

Direction not assertedBalance undeterminableRhea 75823

(5S)-hydroxy-(6E,8Z)-octadecadienoate + reduced [NADH--hemoprotein reductase] + O2 = (5S,18)-dihydroxy-(6E,8Z)-octadecadienoate + oxidized [NADH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 75827

5-oxo-(6E,8Z)-octadecadienoate + reduced [NADH--hemoprotein reductase] + O2 = 5-oxo-18-hydroxy-(6E,8Z)-octadecadienoate + oxidized [NADH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 75831

(5S)-hydroperoxy-(6E,8Z)-octadecadienoate + 2 glutathione = (5S)-hydroxy-(6E,8Z)-octadecadienoate + glutathione disulfide + H2O

Direction not assertedBalancedRhea 75835

serotonin(out) + K(+)(in) + Na(+)(out) + H(+)(in) = serotonin(in) + K(+)(out) + Na(+)(in) + H(+)(out)

Left to rightBalancedTransportRhea 75839

ergothioneine(out) + Na(+)(out) = ergothioneine(in) + Na(+)(in)

Direction not assertedBalancedTransportRhea 75843

9-cis-retinoate + reduced [NADPH--hemoprotein reductase] + O2 = 9-cis-4-hydroxyretinoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 75847

all-trans-4-hydroxyretinoate + reduced [NADPH--hemoprotein reductase] + O2 = all-trans-4-oxoretinoate + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)

Left to rightBalance undeterminableRhea 75851

9-cis-4-hydroxyretinoate + reduced [NADPH--hemoprotein reductase] + O2 = 9-cis-4-oxoretinoate + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)

Left to rightBalance undeterminableRhea 75855

all-trans-4-hydroxy-13,14-dihydroretinoate + reduced [NADPH--hemoprotein reductase] + O2 = all-trans-4-oxo-13,14-dihydroretinoate + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)

Left to rightBalance undeterminableRhea 75859

all-trans-13,14-dihydroretinoate + reduced [NADPH--hemoprotein reductase] + O2 = all-trans-4-hydroxy-13,14-dihydroretinoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 75863

5,6,7,8-tetrahydromethanopterin + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] = 5-methyl-5,6,7,8-tetrahydromethanopterin + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+)

Direction not assertedBalance undeterminableRhea 75867

methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] + (6S)-5,6,7,8-tetrahydrofolate = Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + (6S)-5-methyl-5,6,7,8-tetrahydrofolate + H(+)

Direction not assertedBalance undeterminableRhea 75871

methyl-Co(III)-[quaternary-amine-specific corrinoid protein] + (6S)-5,6,7,8-tetrahydrofolate = Co(I)-[quaternary-amine-specific corrinoid protein] + (6S)-5-methyl-5,6,7,8-tetrahydrofolate + H(+)

Direction not assertedBalance undeterminableRhea 75875

Co(I)-[quaternary-amine-specific corrinoid protein] + L-proline betaine + H(+) = methyl-Co(III)-[quaternary-amine-specific corrinoid protein] + N-methyl-L-proline

Direction not assertedBalance undeterminableRhea 75879

NAD(+) = ADP-1-deoxy-1,O(4)-didehydro-D-ribose + nicotinamide

Direction not assertedBalancedRhea 75883

ADP-1-deoxy-1,O(4)-didehydro-D-ribose + L-arginyl-[protein] = ADP-riboxanated L-argininyl-[protein] + NH4(+) + H(+)

Direction not assertedBalance undeterminableRhea 75887

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