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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Proteins
Interactions
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Reactions
Reach

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

28,551–28,600 of 31,435, by identifier

24,25-dihydrolanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 32-hydroxy-24,25-dihydrolanosterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Left to rightBalance undeterminableRhea 75079
32-oxo-24,25-dihydrolanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)
Left to rightBalance undeterminableRhea 75083
32-hydroxy-24,25-dihydrolanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 32-oxo-24,25-dihydrolanosterol + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)
Left to rightBalance undeterminableRhea 75087
sulfate(out) + 2 chloride(in) = sulfate(in) + 2 chloride(out)
Direction not assertedBalancedTransportRhea 75091
oxalate(out) + 2 chloride(in) = oxalate(in) + 2 chloride(out)
Direction not assertedBalancedTransportRhea 75095
(4Z,15Z)-bilirubin IXalpha + UDP-alpha-D-glucuronate = (4Z,15Z)-bilirubin IXalpha C12-beta-D-glucuronoside + UDP

→ Left to right

Balanced

Rhea 75099

lanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 32-hydroxylanosterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 75103

32-hydroxylanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 32-oxolanosterol + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)

Left to rightBalance undeterminableRhea 75107

32-oxolanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)

Left to rightBalance undeterminableRhea 75111

all-trans-13,14-dihydroretinol + NAD(+) = all-trans-13,14-dihydroretinal + NADH + H(+)

Direction not assertedBalancedRhea 75115

all-trans-13,14-dihydroretinal + NAD(+) + H2O = all-trans-13,14-dihydroretinoate + NADH + 2 H(+)

Left to rightBalancedRhea 75119

(1R)-(1-hydroxyethyl)phosphonate + O2 = acetate + phosphate + 2 H(+)

Direction not assertedBalancedRhea 75123

neopinone = codeinone

Direction not assertedBalancedRhea 75127

neomorphinone = morphinone

Direction not assertedBalancedRhea 75131

neopine + NADP(+) = neopinone + NADPH + H(+)

Direction not assertedBalancedRhea 75135

4-hydroxyprotoasukamycin + NADH + O2 + H(+) = asukamycin + NAD(+) + H2O

Direction not assertedBalancedRhea 75139

prosolanapyrone III = solanapyrone D

Direction not assertedBalancedRhea 75143

(2E,6E,10E)-geranylgeranyl diphosphate = (-)-cyatha-3,12-diene + diphosphate

Direction not assertedBalancedRhea 75147

(2E,6E,10E)-geranylgeranyl diphosphate + H2O = neoverrucosan-5beta-ol + diphosphate

Direction not assertedBalancedRhea 75151

(2E,6E,10E)-geranylgeranyl diphosphate + H2O = verrucosan-2beta-ol + diphosphate

Direction not assertedBalancedRhea 75155

5-methyl-UTP + NAD(+) = 5-methyl-UDP + NADP(+) + H(+)

Direction not assertedBalancedRhea 75159

UTP + NAD(+) = UDP + NADP(+) + H(+)

Direction not assertedBalancedRhea 75163

CTP + NAD(+) = CDP + NADP(+) + H(+)

Direction not assertedBalancedRhea 75167

GTP + NAD(+) = GDP + NADP(+) + H(+)

Direction not assertedBalancedRhea 75171

dATP + NAD(+) = dADP + NADP(+) + H(+)

Direction not assertedBalancedRhea 75175

(2E,6E,10E)-geranylgeranyl diphosphate = (R)-axinyssene + diphosphate

Direction not assertedBalancedRhea 75179

(2E,6E,10E)-geranylgeranyl diphosphate = lydicene + diphosphate

Direction not assertedBalancedRhea 75183

2,5-dihydroxybenzoyl-CoA + H2O = 2,5-dihydroxybenzoate + CoA + H(+)

Direction not assertedBalancedRhea 75187

2-dehydro-3-deoxy-L-fuconate + NAD(+) = 2,4-didehydro-3-deoxy-L-rhamnonate + NADH + H(+)

Direction not assertedBalancedRhea 75191

2-dehydro-3-deoxy-D-arabinonate + NAD(+) = 5-hydroxy-2,4-dioxopentanoate + NADH + H(+)

Direction not assertedBalancedRhea 75195

triuret + H2O = 1-carboxybiuret + NH4(+)

Direction not assertedBalancedRhea 75199

alpha,alpha-trehalose(out) + ATP + H2O = alpha,alpha-trehalose(in) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 75203

Ag(+)(out) = Ag(+)(in)

Direction not assertedBalancedTransportRhea 75207

Cu(+)(out) = Cu(+)(in)

Direction not assertedBalancedTransportRhea 75211

beta-L-fucose + NADP(+) = L-fucono-1,5-lactone + NADPH + H(+)

Direction not assertedBalancedRhea 75215

L-fucono-1,5-lactone + H2O = L-fuconate + H(+)

Direction not assertedBalancedRhea 75219

L-fucono-1,4-lactone + H2O = L-fuconate + H(+)

Direction not assertedBalancedRhea 75223

L-xylono-1,4-lactone + H2O = L-xylonate + H(+)

Direction not assertedBalancedRhea 75227

L-galactono-1,4-lactone + H2O = L-galactonate + H(+)

Direction not assertedBalancedRhea 75231

L-fucono-1,5-lactone = L-fucono-1,4-lactone

Direction not assertedBalancedRhea 75235

N-terminal L-methionyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-[protein] + CoA + H(+)

Direction not assertedBalance undeterminableRhea 75239

N-terminal L-leucyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-leucyl-[protein] + CoA + H(+)

Direction not assertedBalance undeterminableRhea 75243

N-terminal L-prolyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-prolyl-[protein] + CoA + H(+)

Direction not assertedBalance undeterminableRhea 75247

carminate + O2 = 3'-dehydrocarminate + H2O2

Direction not assertedBalancedRhea 75251

mangiferin + O2 = 3'-dehydromangiferin + H2O2

Direction not assertedBalancedRhea 75255

isoorientin + O2 = 3''-dehydroisoorientin + H2O2

Direction not assertedBalancedRhea 75259

isovitexin + O2 = 3''-dehydroisovitexin + H2O2

Direction not assertedBalancedRhea 75263

D-arabinose + NADP(+) = D-arabinono-1,5-lactone + NADPH + H(+)

Direction not assertedBalancedRhea 75267

serotonin + S-adenosyl-L-methionine = 5-methoxytryptamine + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 75271

(9S)-hydroperoxy-(10E,12Z)-octadecadienoate = (10R,11R)-epoxy-(9S)-hydroxy-(12Z)-octadecenoate

Direction not assertedBalancedRhea 75275

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