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CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Reach

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

28,501–28,550 of 31,435, by identifier

(E)-4-coumarate + S-adenosyl-L-methionine = (E)-4-coumaric acid methyl ester + S-adenosyl-L-homocysteine
Direction not assertedBalancedRhea 74879
phloretate + S-adenosyl-L-methionine = 3-(4-hydroxyphenyl)propionic acid methyl ether + S-adenosyl-L-homocysteine
Direction not assertedBalancedRhea 74883
2',3'-cGAMP(in) + ATP + H2O = 2',3'-cGAMP(out) + ADP + phosphate + H(+)
Direction not assertedBalancedTransportRhea 74887
CO2(out) = CO2(in)
Left to rightBalancedTransportRhea 74891
nitric oxide(out) = nitric oxide(in)
Direction not assertedBalancedTransportRhea 74895
(2E)-2-butenoate + holo-[ACP] + ATP = (2E)-butenoyl-[ACP] + AMP + diphosphate
Direction not assertedBalance undeterminableRhea 74899
(2E)-2-butenoate + ATP + H(+) = (2E)-but-2-enoyl-AMP + diphosphate

Direction not assertedBalancedRhea 74903

(2E)-but-2-enoyl-AMP + holo-[ACP] = (2E)-butenoyl-[ACP] + AMP + H(+)

Direction not assertedBalance undeterminableRhea 74907

a (2E)-enoyl fatty acid + holo-[ACP] + ATP = a (2E)-enoyl-[ACP] + AMP + diphosphate

Direction not assertedBalance undeterminableRhea 74911

a (2E)-enoyl fatty acid + ATP + H(+) = a (2E)-2-fatty-enoyl-AMP + diphosphate

Direction not assertedBalance undeterminableRhea 74915

a (2E)-2-fatty-enoyl-AMP + holo-[ACP] = a (2E)-enoyl-[ACP] + AMP + H(+)

Direction not assertedBalance undeterminableRhea 74919

a (3R)-3-[(carboxymethyl)amino]fatty acid + holo-[ACP] + H(+) = a (2E)-enoyl-[ACP] + glycine + H2O

Direction not assertedBalance undeterminableRhea 74923

(3R)-3-[(carboxymethyl)amino]butanoate + holo-[ACP] + H(+) = (2E)-butenoyl-[ACP] + glycine + H2O

Direction not assertedBalance undeterminableRhea 74927

a (3R)-3-[(carboxymethyl)amino]fatty acid + 2 2-oxoglutarate + 2 O2 = a (3R)-3-isocyanyl-fatty acid + 2 succinate + 3 CO2 + 2 H2O

Direction not assertedBalance undeterminableRhea 74931

(3R)-3-[(carboxymethyl)amino]butanoate + 2 2-oxoglutarate + 2 O2 = (3R)-3-isocyanylbutanoate + 2 succinate + 3 CO2 + 2 H2O

Direction not assertedBalancedRhea 74935

a (3R)-3-[(carboxymethyl)amino]fatty acid + 2-oxoglutarate + O2 = a (3R)-3-{[carboxy(hydroxy)methyl]amino}fatty acid + succinate + CO2

Direction not assertedBalance undeterminableRhea 74939

a (3R)-3-{[carboxy(hydroxy)methyl]amino}fatty acid + 2-oxoglutarate + O2 = a (3R)-3-isocyanyl-fatty acid + succinate + 2 CO2 + 2 H2O

Direction not assertedBalance undeterminableRhea 74943

(3R)-3-[(carboxymethyl)amino]butanoate + 2-oxoglutarate + O2 = (3R)-3-{[carboxy(hydroxy)methyl]amino}butanoate + succinate + CO2

Direction not assertedBalancedRhea 74947

(3R)-3-{[carboxy(hydroxy)methyl]amino}butanoate + 2-oxoglutarate + O2 = (3R)-3-isocyanylbutanoate + succinate + 2 CO2 + 2 H2O

Direction not assertedBalancedRhea 74951

a (3R)-3-isocyanyl-fatty acid + holo-[ACP] + ATP = a (3R)-3-isocyanyl-fatty acyl-[ACP] + AMP + diphosphate

Direction not assertedBalance undeterminableRhea 74955

(3R)-3-isocyanylbutanoate + holo-[ACP] + ATP = (3R)-3-isocyanylbutanoyl-[ACP] + AMP + diphosphate

Direction not assertedBalance undeterminableRhea 74959

L-ornithine(in) + L-leucine(out) + Na(+)(out) = L-ornithine(out) + L-leucine(in) + Na(+)(in)

Direction not assertedBalancedTransportRhea 74963

a (3R)-3-isocyanyl-fatty acid + ATP + H(+) = a (3R)-3-isocyanyl-fatty acyl-AMP + diphosphate

Direction not assertedBalance undeterminableRhea 74967

L-lysine(in) + L-leucine(out) + Na(+)(out) = L-lysine(out) + L-leucine(in) + Na(+)(in)

Direction not assertedBalancedTransportRhea 74971

a (3R)-3-isocyanyl-fatty acyl-AMP + holo-[ACP] = a (3R)-3-isocyanyl-fatty acyl-[ACP] + AMP + H(+)

Direction not assertedBalance undeterminableRhea 74975

(3R)-3-isocyanylbutanoate + ATP + H(+) = (3R)-3-isocyanylbutanoyl-AMP + diphosphate

Direction not assertedBalancedRhea 74979

(3R)-3-isocyanylbutanoyl-AMP + holo-[ACP] = (3R)-3-isocyanylbutanoyl-[ACP] + AMP + H(+)

Direction not assertedBalance undeterminableRhea 74983

erythrostominone(in) = erythrostominone(out)

Direction not assertedBalancedTransportRhea 74987

deoxyerythrostominone(in) = deoxyerythrostominone(out)

Direction not assertedBalancedTransportRhea 74991

epierythrostominol(in) = epierythrostominol(out)

Direction not assertedBalancedTransportRhea 74995

deoxyerythrostominol(in) = deoxyerythrostominol(out)

Direction not assertedBalancedTransportRhea 74999

sulfoacetate + ATP + CoA = sulfoacetyl-CoA + AMP + diphosphate

Direction not assertedBalancedRhea 75003

VO(2+)(out) + H(+)(out) = VO(2+)(in) + H(+)(in)

Direction not assertedBalancedTransportRhea 75007

1,2,3-tri-(9Z-octadecenoyl)-glycerol + 9-hydroxy-octadecanoate = 9-(9Z-octadecenoyloxy)-octadecanoate + 2,3-di-(9Z)-octadecenoyl-sn-glycerol

Direction not assertedBalancedRhea 75011

1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + 9-hydroxy-octadecanoate = 9-hexadecanoyloxy-octadecanoate + 2,3-di-(9Z)-octadecenoyl-sn-glycerol

Direction not assertedBalancedRhea 75015

1,2,3-tri-(10Z)-heptadecenoylglycerol + 9-hydroxy-octadecanoate = 2,3-di-(10Z-heptadecenoyl)-sn-glycerol + 9-(10Z-heptadecenoyloxy)-octadecanoate

Direction not assertedBalancedRhea 75019

1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + 9-hydroxy-octadecanoate = 2,3-di-(9Z,12Z)-octadecadienoyl-sn-glycerol + 9-(9Z,12Z-octadecadienoyloxy)-octadecanoate

Direction not assertedBalancedRhea 75023

1,2,3-tri-(9Z)-hexadecenoylglycerol + 9-hydroxy-octadecanoate = 2,3-di-(9Z)-hexadecenoyl-sn-glycerol + 9-(9Z-hexadecenoyloxy)-octadecanoate

Direction not assertedBalancedRhea 75027

9-hydroxy-octadecanoate + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 9-(9Z-octadecenoyloxy)-octadecanoate + 2-(9Z-octadecenoyl)-glycerol

Direction not assertedBalancedRhea 75031

1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + 9-hydroxy-octadecanoate = 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + 9-(9Z-octadecenoyloxy)-octadecanoate

Direction not assertedBalancedRhea 75035

acetyl-CoA(in) = acetyl-CoA(out)

Left to rightBalancedTransportRhea 75039

L-cystine(out) + L-leucine(in) = L-cystine(in) + L-leucine(out)

Direction not assertedBalancedTransportRhea 75043

N(omega),N(omega)-dimethyl-L-arginine(out) = N(omega),N(omega)-dimethyl-L-arginine(in)

Direction not assertedBalancedTransportRhea 75047

chenodeoxycholate(out) = chenodeoxycholate(in)

Direction not assertedBalancedTransportRhea 75051

(E)-caffeate + H(+) = 3,4-dihydroxystyrene + CO2

Direction not assertedBalancedRhea 75055

K(+)(in) + 2 hydrogencarbonate(in) + chloride(out) = K(+)(out) + 2 hydrogencarbonate(out) + chloride(in)

Direction not assertedBalancedTransportRhea 75059

Li(+)(in) + 2 hydrogencarbonate(in) + chloride(out) = Li(+)(out) + 2 hydrogencarbonate(out) + chloride(in)

Direction not assertedBalancedTransportRhea 75063

Rb(+)(in) + 2 hydrogencarbonate(in) + chloride(out) = Rb(+)(out) + 2 hydrogencarbonate(out) + chloride(in)

Direction not assertedBalancedTransportRhea 75067

Cs(+)(in) + 2 hydrogencarbonate(in) + chloride(out) = Cs(+)(out) + 2 hydrogencarbonate(out) + chloride(in)

Direction not assertedBalancedTransportRhea 75071

dihydro-6-demethylsterigmatocystin + S-adenosyl-L-methionine = dihydrosterigmatocystin + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 75075

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