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CompoundsSubstances with curated findings
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ProteinsTransporters and enzymes
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ReactionsRhea and Human-GEM, by subsystem
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PathwaysReactions grouped under one name
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
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Reference

Evidence

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

28,451–28,500 of 31,435, by identifier

UDP-beta-L-arabinofuranose(in) + UMP(out) = UDP-beta-L-arabinofuranose(out) + UMP(in)
Direction not assertedBalancedTransportRhea 74679
2 archaeol + 2 AH2 + 4 S-adenosyl-L-methionine = glycerol dibiphytanyl glycerol tetraether + 4 5'-deoxyadenosine + 4 L-methionine + 2 A + 4 H(+)
Direction not assertedBalancedRhea 74683
a 2,3-di-O-phytanyl-sn-glycerophospholipid + AH2 + 2 S-adenosyl-L-methionine = a macrocyclic archaeaol phospholipid + 2 5'-deoxyadenosine + 2 L-methionine + A + 2 H(+)
Direction not assertedBalance undeterminableRhea 74687
2 a 2,3-di-O-phytanyl-sn-glycerophospholipid + 2 AH2 + 4 S-adenosyl-L-methionine = a glycerol dibiphytanyl glycerol tetraether phospholipid + 4 5'-deoxyadenosine + 4 L-methionine + 2 A + 4 H(+)
Direction not assertedBalance undeterminableRhea 74691
(+)-exo-beta-bergamotene + reduced [NADPH--hemoprotein reductase] + O2 = (5R)-hydroxy-beta-trans-bergamotene + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Direction not assertedBalance undeterminableRhea 74695
(5R)-hydroxy-beta-trans-bergamotene + O2 = (3S)-3-[2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-4-methylidenecyclohexan-1-one + H2O

Direction not assertedBalancedRhea 74699

(3S)-3-[2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-4-methylidenecyclohexan-1-one + reduced [NADPH--hemoprotein reductase] + O2 = 5-dehydro-6-demethoxyfumagillol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 74703

fumagillol + NADP(+) = 5-dehydrofumagillol + NADPH + H(+)

Direction not assertedBalancedRhea 74707

5-dehydro-6-demethoxy-6-hydroxyfumagillol + S-adenosyl-L-methionine = 5-dehydrofumagillol + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 74711

3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine = 3,3'-O-dimethylquercetin + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 74715

myricetin + S-adenosyl-L-methionine = 7-O-methylmyricetin + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 74719

isorhamnetin + S-adenosyl-L-methionine = 3',4'-O-dimethylquercetin + S-adenosyl-L-homocysteine + 2 H(+)

Direction not assertedBalancedRhea 74723

holo-[polyketide synthase] + 5 malonyl-CoA + acetyl-CoA + 5 NADPH + 10 H(+) = dodecapentaneoyl-[polyketide synthase] + 5 CO2 + 5 NADP(+) + 6 CoA + 5 H2O

Direction not assertedBalance undeterminableRhea 74727

rhamnetin + S-adenosyl-L-methionine = 7,4'-O-dimethylquercetin + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 74731

syringetin + S-adenosyl-L-methionine = 7,3',5'-O-trimethylmyricetin + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 74735

3',4',5'-O-trimethylmyricetin + S-adenosyl-L-methionine = 7,3',4',5'-O-tetramethylmyricetin + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 74739

kaempferol + S-adenosyl-L-methionine = 3-O-methylkaempferol + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 74743

myricetin + S-adenosyl-L-methionine = 3-O-methylmyricetin + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 74747

fumagillol + dodecapentaneoyl-[polyketide synthase] = prefumagillin + holo-[polyketide synthase]

Direction not assertedBalance undeterminableRhea 74751

kaempferide + S-adenosyl-L-methionine = 3,4'-O-dimethylkaempferol + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 74755

isorhamnetin + S-adenosyl-L-methionine = 3,3'-O-dimethylquercetin + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 74759

rhamnetin + S-adenosyl-L-methionine = 3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 74763

syringetin + S-adenosyl-L-methionine = 3,3',5'-O-trimethylmyricetin + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 74767

3',4',5'-O-trimethylmyricetin + S-adenosyl-L-methionine = 3,3',4',5'-O-tetramethylmyricetin + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 74771

kaempferide + S-adenosyl-L-methionine = 7,4'-O-dimethylkaempferol + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 74775

laricitrin + S-adenosyl-L-methionine = 3,3'-O-dimethylmyricetin + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 74779

tyramine(in) = tyramine(out)

Direction not assertedBalancedTransportRhea 74783

L-histidyl-L-proline diketopiperazine(in) = L-histidyl-L-proline diketopiperazine(out)

Direction not assertedBalancedTransportRhea 74787

(R)-salsolinol(in) = (R)-salsolinol(out)

Direction not assertedBalancedTransportRhea 74791

N-methyl-(R)-salsolinol(in) = N-methyl-(R)-salsolinol(out)

Direction not assertedBalancedTransportRhea 74795

2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA

Direction not assertedBalancedRhea 74799

2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA

Direction not assertedBalancedRhea 74803

2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA

Direction not assertedBalancedRhea 74807

2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA

Direction not assertedBalancedRhea 74811

2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA

Direction not assertedBalancedRhea 74815

glutathione(in) = glutathione(out)

Direction not assertedBalancedTransportRhea 74819

2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA

Direction not assertedBalancedRhea 74823

UDP-alpha-D-galacturonate(in) + UMP(out) = UDP-alpha-D-galacturonate(out) + UMP(in)

Direction not assertedBalancedTransportRhea 74827

UDP-alpha-D-xylose(in) + UDP-alpha-D-glucuronate(out) = UDP-alpha-D-xylose(out) + UDP-alpha-D-glucuronate(in)

Left to rightBalancedTransportRhea 74831

UDP-N-acetyl-alpha-D-galactosamine(in) + UDP-alpha-D-glucuronate(out) = UDP-N-acetyl-alpha-D-galactosamine(out) + UDP-alpha-D-glucuronate(in)

Left to rightBalancedTransportRhea 74835

UDP-alpha-D-glucuronate(out) + UDP(in) = UDP-alpha-D-glucuronate(in) + UDP(out)

Direction not assertedBalancedTransportRhea 74839

a ganglioside GM1b + 3'-phosphoadenylyl sulfate = an 8-O-sulfo-ganglioside GM1b + adenosine 3',5'-bisphosphate + H(+)

Left to rightBalance undeterminableRhea 74843

1D-myo-inositol 1,2,3,4,5-pentakisphosphate + ATP = 3-diphospho-1D-myo-inositol 1,2,4,5-tetrakisphosphate + ADP

Direction not assertedBalancedRhea 74847

dopamine + acetaldehyde = (R)-salsolinol + H2O

Direction not assertedBalancedRhea 74851

dopamine + pyruvate = (R)-salsolinol-1-carboxylate + H2O

Direction not assertedBalancedRhea 74855

dopamine + formaldehyde = norsalsolinol + H2O

Direction not assertedBalancedRhea 74859

(R)-salsolinol + S-adenosyl-L-methionine = N-methyl-(R)-salsolinol + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 74863

(E)-caffeyl aldehyde + NADP(+) + CoA = (E)-caffeoyl-CoA + NADPH + H(+)

Direction not assertedBalancedRhea 74867

(E)-cinnamate + S-adenosyl-L-methionine = (E)-cinnamic acid methyl ester + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 74871

3-phenylpropanoate + S-adenosyl-L-methionine = 3-phenylpropanoic acid methyl ester + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 74875

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