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CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

27,901–27,950 of 31,435, by identifier

6 malonyl-CoA + 2 acetyl-CoA + 5 H(+) = o-orsellinate depside + 6 CO2 + 8 CoA + H2O
Direction not assertedBalancedRhea 72467
D-threo-isocitrate(in) + citrate(out) = D-threo-isocitrate(out) + citrate(in)
Direction not assertedBalancedTransportRhea 72471
cis-aconitate(in) + citrate(out) = cis-aconitate(out) + citrate(in)
Direction not assertedBalancedTransportRhea 72475
trans-aconitate(in) + citrate(out) = trans-aconitate(out) + citrate(in)
Direction not assertedBalancedTransportRhea 72479
(S)-malate(in) + citrate(out) = (S)-malate(out) + citrate(in)
Direction not assertedBalancedTransportRhea 72483
phosphoenolpyruvate(in) + citrate(out) = phosphoenolpyruvate(out) + citrate(in)
Direction not assertedBalancedTransportRhea 72487

maleate(in) + citrate(out) = maleate(out) + citrate(in)

Direction not assertedBalancedTransportRhea 72491

prostaglandin E2(out) + glutarate(in) = prostaglandin E2(in) + glutarate(out)

Direction not assertedBalancedTransportRhea 72495

prostaglandin E2(out) + 2-oxoglutarate(in) = prostaglandin E2(in) + 2-oxoglutarate(out)

Direction not assertedBalancedTransportRhea 72499

prostaglandin F2alpha(out) + glutarate(in) = prostaglandin F2alpha(in) + glutarate(out)

Direction not assertedBalancedTransportRhea 72503

prostaglandin F2alpha(out) + 2-oxoglutarate(in) = prostaglandin F2alpha(in) + 2-oxoglutarate(out)

Direction not assertedBalancedTransportRhea 72507

(R)-carnitine(out) + 2-oxoglutarate(in) = (R)-carnitine(in) + 2-oxoglutarate(out)

Direction not assertedBalancedTransportRhea 72511

glutarate(in) + (R)-carnitine(out) = glutarate(out) + (R)-carnitine(in)

Direction not assertedBalancedTransportRhea 72515

phenazine-1,6-dicarboxylate + NADH + O2 + 2 H(+) = 6-hydroxyphenazine-1-carboxylate + CO2 + NAD(+) + H2O

Direction not assertedBalancedRhea 72519

1,6-dihydroxyphenazine + S-adenosyl-L-methionine = 1-hydroxy-6-methoxyphenazine + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 72523

1-hydroxy-6-methoxyphenazine + S-adenosyl-L-methionine = 1,6-dimethoxyphenazine + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 72527

methyl beta-D-galactoside(out) + ATP + H2O = methyl beta-D-galactoside(in) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 72531

vanillin + NADP(+) + H2O = vanillate + NADPH + 2 H(+)

Direction not assertedBalancedRhea 72535

3,4-dihydroxybenzaldehyde + NADP(+) + H2O = 3,4-dihydroxybenzoate + NADPH + 2 H(+)

Direction not assertedBalancedRhea 72539

dehydroepiandrosterone 3-sulfate(out) + 2-oxoglutarate(in) = dehydroepiandrosterone 3-sulfate(in) + 2-oxoglutarate(out)

Direction not assertedBalancedTransportRhea 72543

taurocholate(out) + 2-oxoglutarate(in) = taurocholate(in) + 2-oxoglutarate(out)

Direction not assertedBalancedTransportRhea 72547

urate(in) + glutarate(out) = urate(out) + glutarate(in)

Direction not assertedBalancedTransportRhea 72551

propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)

Direction not assertedBalancedTransportRhea 72555

pentanoate(in) + estrone 3-sulfate(out) = pentanoate(out) + estrone 3-sulfate(in)

Direction not assertedBalancedTransportRhea 72559

dehydroepiandrosterone 3-sulfate(in) + butanoate(out) = dehydroepiandrosterone 3-sulfate(out) + butanoate(in)

Direction not assertedBalancedTransportRhea 72563

propanoate(out) + dehydroepiandrosterone 3-sulfate(in) = propanoate(in) + dehydroepiandrosterone 3-sulfate(out)

Direction not assertedBalancedTransportRhea 72567

pentanoate(out) + dehydroepiandrosterone 3-sulfate(in) = pentanoate(in) + dehydroepiandrosterone 3-sulfate(out)

Direction not assertedBalancedTransportRhea 72571

(22E)-3-oxochola-4,22-dien-24-oyl-CoA + H2O = (22R)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA

Direction not assertedBalancedRhea 72575

(22E)-3-oxochola-4,22-dien-24-oyl-CoA + H2O = (22S)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA

Direction not assertedBalancedRhea 72579

(22S)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA + NAD(+) = 3,22-dioxochol-4-en-24-oyl-CoA + NADH + H(+)

Direction not assertedBalancedRhea 72583

(E)-sinapate + ATP + CoA = (E)-sinapoyl-CoA + AMP + diphosphate

Direction not assertedBalancedRhea 72587

D-glucuronate(out) + H(+)(out) = D-glucuronate(in) + H(+)(in)

Left to rightBalancedTransportRhea 72591

N-acetyl-L-aspartyl-L-glutamate(out) + H(+)(out) = N-acetyl-L-aspartyl-L-glutamate(in) + H(+)(in)

Direction not assertedBalancedTransportRhea 72595

N-acetyl-L-aspartyl-L-glutamate(out) = N-acetyl-L-aspartyl-L-glutamate(in)

Left to rightBalancedTransportRhea 72599

(E)-sinapate + ATP + H(+) = (E)-sinapoyl-AMP + diphosphate

Direction not assertedBalancedRhea 72603

(E)-sinapoyl-AMP + CoA = (E)-sinapoyl-CoA + AMP + H(+)

Direction not assertedBalancedRhea 72607

L-alanyl-L-lysine(out) + H(+)(out) = L-alanyl-L-lysine(in) + H(+)(in)

Left to rightBalancedTransportRhea 72611

L-alanyl-L-valine(out) + H(+)(out) = L-alanyl-L-valine(in) + H(+)(in)

Left to rightBalancedTransportRhea 72615

2-methoxybenzoate + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) = methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] + salicylate

Direction not assertedBalance undeterminableRhea 72619

N-(2-hydroxy-fatty acyl)-dihydroceramide + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) = inositol-1-phospho-N-(2-hydroxy-fatty acyl)-dihydroceramide + a 1,2-diacyl-sn-glycerol

Direction not assertedBalance undeterminableRhea 72623

Zn(2+)(in) + 2 H(+)(out) = Zn(2+)(out) + 2 H(+)(in)

Direction not assertedBalancedTransportRhea 72627

3 Li(+)(out) + Ca(2+)(in) = 3 Li(+)(in) + Ca(2+)(out)

Direction not assertedBalancedTransportRhea 72631

1-hydroxy-6-methoxyphenazine N(10)-oxide + S-adenosyl-L-methionine = 1,6-dimethoxyphenazine N(5)-oxide + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 72635

1,6-dihydroxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-methionine = 1-hydroxy-6-methoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 72639

1-hydroxy-6-methoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-methionine = 1,6-dimethoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 72643

1,6-dihydroxyphenazine + NADPH + O2 = 1,6-dihydroxyphenazine N(5)-oxide + NADP(+) + H2O

Direction not assertedBalancedRhea 72647

1,6-dihydroxyphenazine N(5)-oxide + NADPH + O2 = 1,6-dihydroxyphenazine N(5),N(10)-dioxide + NADP(+) + H2O

Direction not assertedBalancedRhea 72651

1-hydroxy-6-methoxyphenazine + NADPH + O2 = 1-hydroxy-6-methoxyphenazine N(10)-oxide + NADP(+) + H2O

Direction not assertedBalancedRhea 72655

quinolin-8-ol + NADPH + O2 = 8-hydroxyquinoline N-oxide + NADP(+) + H2O

Direction not assertedBalancedRhea 72659

C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-phenylalanyl-[tubulin] + H2O = C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-phenylalanine

Left to rightBalance undeterminableRhea 72663

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