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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Interactions
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Reactions
Reach

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Organisms
Materials
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Diseases

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Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

27,801–27,850 of 31,435, by identifier

(2S)-2-aminobutanoate + L-glutamate + ATP = gamma-L-glutamyl-(2S)-2-aminobutanoate + ADP + phosphate + H(+)
Left to rightBalancedRhea 72067
L-histidyl-[protein] + NAD(+) = N(tele)-(ADP-D-ribosyl)-L-histidyl-[protein] + nicotinamide + H(+)
Left to rightBalance undeterminableRhea 72071
gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)
Left to rightBalancedRhea 72075
selenate(out) + 3 Na(+)(out) = selenate(in) + 3 Na(+)(in)
Direction not assertedBalancedTransportRhea 72079
ADP-alpha-D-ribose 1'',2''-cyclic phosphate + H2O = ADP-alpha-D-ribose 1''-phosphate + H(+)
Direction not assertedBalancedRhea 72083
taurodeoxycholate(out) + 2 Na(+)(out) = taurodeoxycholate(in) + 2 Na(+)(in)
Direction not assertedBalancedTransportRhea 72087

(R)-carnitine(out) + Na(+)(out) = (R)-carnitine(in) + Na(+)(in)

Direction not assertedBalancedTransportRhea 72091

(S)-carnitine(out) + Na(+)(out) = (S)-carnitine(in) + Na(+)(in)

Direction not assertedBalancedTransportRhea 72095

O-acetyl-(R)-carnitine(out) + Na(+)(out) = O-acetyl-(R)-carnitine(in) + Na(+)(in)

Direction not assertedBalancedTransportRhea 72099

O-propanoyl-(R)-carnitine(out) + Na(+)(out) = O-propanoyl-(R)-carnitine(in) + Na(+)(in)

Direction not assertedBalancedTransportRhea 72103

an O-acyl-(R)-carnitine(out) + Na(+)(out) = an O-acyl-(R)-carnitine(in) + Na(+)(in)

Direction not assertedBalance undeterminableTransportRhea 72107

L-glutamyl-L-arginyl-glycyl-L-methionyl-L-threonine(out) + Na(+)(out) = L-glutamyl-L-arginyl-glycyl-L-methionyl-L-threonine(in) + Na(+)(in)

Direction not assertedBalancedTransportRhea 72111

glycine betaine(out) + Na(+)(out) = glycine betaine(in) + Na(+)(in)

Left to rightBalancedTransportRhea 72115

glycine betaine(out) + (R)-carnitine(in) = glycine betaine(in) + (R)-carnitine(out)

Direction not assertedBalancedTransportRhea 72119

O-butanoyl-(R)-carnitine(out) + Na(+)(out) = O-butanoyl-(R)-carnitine(in) + Na(+)(in)

Direction not assertedBalancedTransportRhea 72123

agmatine(in) + H(+)(out) = agmatine(out) + H(+)(in)

ReversibleBalancedTransportRhea 72127

agmatine(out) = agmatine(in)

ReversibleBalancedTransportRhea 72131

putrescine(out) = putrescine(in)

Direction not assertedBalancedTransportRhea 72135

estrone 3-sulfate(in) + H(+)(out) = estrone 3-sulfate(out) + H(+)(in)

Direction not assertedBalancedTransportRhea 72139

GTP + AH2 + S-adenosyl-L-methionine = 3'-deoxy-3',4'-didehydro-GTP + 5'-deoxyadenosine + L-methionine + A + H2O + H(+)

Direction not assertedBalancedRhea 72143

UTP + AH2 + S-adenosyl-L-methionine = 3'-deoxy-3',4'-didehydro-UTP + 5'-deoxyadenosine + L-methionine + A + H2O + H(+)

Direction not assertedBalancedRhea 72147

estrone 3-sulfate(out) + glutarate(in) = estrone 3-sulfate(in) + glutarate(out)

Direction not assertedBalancedTransportRhea 72151

17beta-estradiol 17-O-(beta-D-glucuronate)(out) + glutarate(in) = 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + glutarate(out)

Direction not assertedBalancedTransportRhea 72155

taurocholate(out) + glutarate(in) = taurocholate(in) + glutarate(out)

Direction not assertedBalancedTransportRhea 72159

O-butanoyl-(R)-carnitine(out) + chloride(out) + 2 Na(+)(out) = O-butanoyl-(R)-carnitine(in) + chloride(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 72163

taurohyodeoxycholate(out) + 2 Na(+)(out) = taurohyodeoxycholate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 72167

taurohyocholate(out) + 2 Na(+)(out) = taurohyocholate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 72171

5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(out) + glutarate(in) = 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(in) + glutarate(out)

Direction not assertedBalancedTransportRhea 72175

tauro-beta-muricholate(out) + 2 Na(+)(out) = tauro-beta-muricholate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 72179

creatinine(in) + H(+)(out) = creatinine(out) + H(+)(in)

Direction not assertedBalancedTransportRhea 72183

sucrose(out) + H(+)(out) = sucrose(in) + H(+)(in)

Direction not assertedBalancedTransportRhea 72187

cholesterol + 2 reduced [NADPH--hemoprotein reductase] + 2 O2 = (16S,22S)-dihydroxycholesterol + 2 oxidized [NADPH--hemoprotein reductase] + 2 H2O + 2 H(+)

Direction not assertedBalance undeterminableRhea 72191

citrate(out) + 3 Na(+)(out) = citrate(in) + 3 Na(+)(in)

Direction not assertedBalancedTransportRhea 72195

Ca(2+)(in) + 2 H(+)(out) = Ca(2+)(out) + 2 H(+)(in)

Direction not assertedBalancedTransportRhea 72199

hydrogencarbonate(in) + 2 chloride(out) = hydrogencarbonate(out) + 2 chloride(in)

Direction not assertedBalancedTransportRhea 72203

2 hydrogencarbonate(in) + chloride(out) = 2 hydrogencarbonate(out) + chloride(in)

Direction not assertedBalancedTransportRhea 72207

(+)-isoborneol + NAD(+) = (1S,4S)-camphor + NADH + H(+)

Direction not assertedBalancedRhea 72211

2 hydrogencarbonate(out) + Na(+)(out) = 2 hydrogencarbonate(in) + Na(+)(in)

Direction not assertedBalancedTransportRhea 72215

3 hydrogencarbonate(out) + Na(+)(out) = 3 hydrogencarbonate(in) + Na(+)(in)

Direction not assertedBalancedTransportRhea 72219

4-hydroxy-L-proline(out) + chloride(out) + 2 Na(+)(out) = 4-hydroxy-L-proline(in) + chloride(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 72223

sarcosine(out) + chloride(out) + 2 Na(+)(out) = sarcosine(in) + chloride(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 72227

N-methyl-L-proline(out) + chloride(out) + 2 Na(+)(out) = N-methyl-L-proline(in) + chloride(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 72231

2-methyl-2-(methylamino)propanoate(out) + chloride(out) + 2 Na(+)(out) = 2-methyl-2-(methylamino)propanoate(in) + chloride(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 72235

estrone 3-sulfate(out) + L-glutamate(in) = estrone 3-sulfate(in) + L-glutamate(out)

Left to rightBalancedTransportRhea 72239

catechol + S-adenosyl-L-methionine = guaiacol + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 72243

(R)-noradrenaline + S-adenosyl-L-methionine = (R)-normetanephrine + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 72247

(R)-adrenaline + S-adenosyl-L-methionine = (R)-metanephrine + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 72251

dopamine + S-adenosyl-L-methionine = 3-methoxytyramine + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 72255

L-dopa + S-adenosyl-L-methionine = 3-O-methyl-L-dopa + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 72259

oxalate(in) + chloride(out) = oxalate(out) + chloride(in)

Direction not assertedBalancedTransportRhea 72263

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