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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

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Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

27,751–27,800 of 31,435, by identifier

glycodeoxycholate(out) = glycodeoxycholate(in)
Direction not assertedBalancedTransportRhea 71867
(S)-3-hydroxybutanoate(out) + H(+)(out) = (S)-3-hydroxybutanoate(in) + H(+)(in)
Direction not assertedBalancedTransportRhea 71871
taurocholate(out) + 2 Na(+)(out) = taurocholate(in) + 2 Na(+)(in)
Direction not assertedBalancedTransportRhea 71875
2'-deoxyguanosine + NAD(+) = N(2)-(ADP-D-ribosyl)-2'-deoxyguanosine + nicotinamide + H(+)
Direction not assertedBalancedRhea 71879
GMP + NAD(+) = N(2)-(ADP-D-ribosyl)-GMP + nicotinamide + H(+)
Direction not assertedBalancedRhea 71883
GTP + NAD(+) = N(2)-(ADP-D-ribosyl)-GTP + nicotinamide + H(+)
Direction not assertedBalancedRhea 71887
dGMP + NAD(+) = N(2)-(ADP-D-ribosyl)-dGMP + nicotinamide + H(+)

Direction not assertedBalancedRhea 71891

dGTP + NAD(+) = N(2)-(ADP-D-ribosyl)-dGTP + nicotinamide + H(+)

Direction not assertedBalancedRhea 71895

3',5'-cyclic GMP + NAD(+) = N(2)-(ADP-D-ribosyl)-3',5'-cyclic GMP + nicotinamide + H(+)

Direction not assertedBalancedRhea 71899

guanine + NAD(+) = N(2)-(ADP-D-ribosyl)-guanine + nicotinamide + H(+)

Direction not assertedBalancedRhea 71903

GDP + NAD(+) = N(2)-(ADP-D-ribosyl)-GDP + nicotinamide + H(+)

Direction not assertedBalancedRhea 71907

cholate(out) + 2 Na(+)(out) = cholate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71911

tauronorcholate(out) + 2 Na(+)(out) = tauronorcholate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71915

succinate(out) + 3 Na(+)(out) = succinate(in) + 3 Na(+)(in)

Direction not assertedBalancedTransportRhea 71919

taurochenodeoxycholate(out) + 2 Na(+)(out) = taurochenodeoxycholate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71923

tauroursodeoxycholate(out) + 2 Na(+)(out) = tauroursodeoxycholate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71927

fumarate(out) + 3 Na(+)(out) = fumarate(in) + 3 Na(+)(in)

Direction not assertedBalancedTransportRhea 71931

glycocholate(out) + 2 Na(+)(out) = glycocholate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71935

2-oxoglutarate(out) + 3 Na(+)(out) = 2-oxoglutarate(in) + 3 Na(+)(in)

Direction not assertedBalancedTransportRhea 71939

(S)-malate(out) + 3 Na(+)(out) = (S)-malate(in) + 3 Na(+)(in)

Direction not assertedBalancedTransportRhea 71943

N-acetyl-L-aspartate(out) + 3 Na(+)(out) = N-acetyl-L-aspartate(in) + 3 Na(+)(in)

Direction not assertedBalancedTransportRhea 71947

sulfate(out) + 3 Na(+)(out) = sulfate(in) + 3 Na(+)(in)

Direction not assertedBalancedTransportRhea 71951

glutarate(out) + 3 Na(+)(out) = glutarate(in) + 3 Na(+)(in)

Direction not assertedBalancedTransportRhea 71955

oxaloacetate(out) + 3 Na(+)(out) = oxaloacetate(in) + 3 Na(+)(in)

Direction not assertedBalancedTransportRhea 71959

(R)-2-hydroxyglutarate(out) + 3 Na(+)(out) = (R)-2-hydroxyglutarate(in) + 3 Na(+)(in)

Direction not assertedBalancedTransportRhea 71963

(S)-2-hydroxyglutarate(out) + 3 Na(+)(out) = (S)-2-hydroxyglutarate(in) + 3 Na(+)(in)

Direction not assertedBalancedTransportRhea 71967

3-hydroxyglutarate(out) + 3 Na(+)(out) = 3-hydroxyglutarate(in) + 3 Na(+)(in)

Direction not assertedBalancedTransportRhea 71971

glutathione(out) + 3 Na(+)(out) = glutathione(in) + 3 Na(+)(in)

Direction not assertedBalancedTransportRhea 71975

(2E,6E,10E,14E)-geranylfarnesyl diphosphate = fusoxypene A + diphosphate

Direction not assertedBalancedRhea 71979

(2E,6E,10E,14E)-geranylfarnesyl diphosphate = fusoxypene B + diphosphate

Direction not assertedBalancedRhea 71983

(2E,6E,10E,14E)-geranylfarnesyl diphosphate = fusoxypene C + diphosphate

Direction not assertedBalancedRhea 71987

(2E,6E,10E,14E)-geranylfarnesyl diphosphate = (-)-astellatene + diphosphate

Direction not assertedBalancedRhea 71991

(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O = preaspterpenacid acid I + diphosphate

Direction not assertedBalancedRhea 71995

preaspterpenacid acid I + reduced [NADPH--hemoprotein reductase] + O2 = preaspterpenacid acid II + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 71999

urate(out) + (S)-lactate(in) = urate(in) + (S)-lactate(out)

Left to rightBalancedTransportRhea 72003

urate(out) + succinate(in) = urate(in) + succinate(out)

Left to rightBalancedTransportRhea 72007

urate(out) + glutathione(in) = urate(in) + glutathione(out)

Left to rightBalancedTransportRhea 72011

malate + 6 malonyl-CoA + acetyl-CoA + 2 AH2 + 2 S-adenosyl-L-methionine + 5 NADPH + 9 H(+) = trihazone A + 2 A + 2 S-adenosyl-L-homocysteine + 6 CO2 + 5 NADP(+) + 7 CoA + 6 H2O

Direction not assertedBalancedRhea 72015

trihazone A + 2-oxoglutarate + O2 + H(+) = trihazone D + succinate + 2 CO2 + H2O

Direction not assertedBalancedRhea 72019

nicotinate(in) + urate(out) = nicotinate(out) + urate(in)

Left to rightBalancedTransportRhea 72023

(E)-sinapaldehyde + L-proline = (E)-nesocodin (alcohol-form) + H2O

Direction not assertedBalancedRhea 72027

(E)-sinapyl alcohol + O2 = (E)-sinapaldehyde + H2O2

Direction not assertedBalancedRhea 72031

phosphate(in) + ATP(out) + 2 H(+)(out) = phosphate(out) + ATP(in) + 2 H(+)(in)

Direction not assertedBalancedTransportRhea 72035

orotate(out) + nicotinate(in) = orotate(in) + nicotinate(out)

Direction not assertedBalancedTransportRhea 72039

orotate(out) + L-glutamate(in) = orotate(in) + L-glutamate(out)

Direction not assertedBalancedTransportRhea 72043

D-allo-threonine + D-leucine + D-alanine + L-proline + 2 L-leucine + A = fusahexin + AH2 + 6 H2O

Direction not assertedBalancedRhea 72047

butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)

Direction not assertedBalancedTransportRhea 72051

glycodeoxycholate(out) + 2 Na(+)(out) = glycodeoxycholate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 72055

glycochenodeoxycholate(out) + 2 Na(+)(out) = glycochenodeoxycholate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 72059

glycoursodeoxycholate(out) + 2 Na(+)(out) = glycoursodeoxycholate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 72063

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