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Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
Interactions
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Chemistry

Reactions
Reach

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Processes
Anatomy
Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

27,701–27,750 of 31,435, by identifier

malonate(out) + succinate(in) = malonate(in) + succinate(out)
Direction not assertedBalancedTransportRhea 71667
glycyl-L-glutamine(out) + H(+)(out) = glycyl-L-glutamine(in) + H(+)(in)
ReversibleBalancedTransportRhea 71671
glycyl-L-leucine(out) + H(+)(out) = glycyl-L-leucine(in) + H(+)(in)
Left to rightBalancedTransportRhea 71675
L-lysyl-glycine(out) + H(+)(out) = L-lysyl-glycine(in) + H(+)(in)
ReversibleBalancedTransportRhea 71679
L-aspartyl-glycine(out) + 2 H(+)(out) = L-aspartyl-glycine(in) + 2 H(+)(in)
Left to rightBalancedTransportRhea 71683
glycyl-L-aspartate(out) + 2 H(+)(out) = glycyl-L-aspartate(in) + 2 H(+)(in)
ReversibleBalancedTransportRhea 71687
glycyl-L-glutamate(out) + 2 H(+)(out) = glycyl-L-glutamate(in) + 2 H(+)(in)

Left to rightBalancedTransportRhea 71691

L-alanyl-L-aspartate(out) + 2 H(+)(out) = L-alanyl-L-aspartate(in) + 2 H(+)(in)

Left to rightBalancedTransportRhea 71695

L-phenylalanyl-L-leucine(out) + H(+)(out) = L-phenylalanyl-L-leucine(in) + H(+)(in)

Left to rightBalancedTransportRhea 71699

taurocholate(out) = taurocholate(in)

ReversibleBalancedTransportRhea 71703

L-phenylalanyl-L-phenylalanine(out) + H(+)(out) = L-phenylalanyl-L-phenylalanine(in) + H(+)(in)

Left to rightBalancedTransportRhea 71707

L-tyrosylglycine(out) + H(+)(out) = L-tyrosylglycine(in) + H(+)(in)

Left to rightBalancedTransportRhea 71711

L-leucyl-L-leucine(out) + H(+)(out) = L-leucyl-L-leucine(in) + H(+)(in)

Left to rightBalancedTransportRhea 71715

L-methionyl-L-phenylalanyl-L-methionine(out) + H(+)(out) = L-methionyl-L-phenylalanyl-L-methionine(in) + H(+)(in)

Left to rightBalancedTransportRhea 71719

L-alanyl-L-leucyl-L-alanine(out) + H(+)(out) = L-alanyl-L-leucyl-L-alanine(in) + H(+)(in)

Left to rightBalancedTransportRhea 71723

fumarate(in) + citrate(out) = fumarate(out) + citrate(in)

Direction not assertedBalancedTransportRhea 71727

tartrate(in) + citrate(out) = tartrate(out) + citrate(in)

Direction not assertedBalancedTransportRhea 71731

formyl-CoA + succinate = succinyl-CoA + formate

Direction not assertedBalancedRhea 71735

2-oxoadipate(in) + 2-oxoglutarate(out) = 2-oxoadipate(out) + 2-oxoglutarate(in)

Direction not assertedBalancedTransportRhea 71739

hexanedioate(in) + 2-oxoglutarate(out) = hexanedioate(out) + 2-oxoglutarate(in)

Direction not assertedBalancedTransportRhea 71743

L-2-aminoadipate(in) + 2-oxoglutarate(out) = L-2-aminoadipate(out) + 2-oxoglutarate(in)

Direction not assertedBalancedTransportRhea 71747

glutarate(in) + 2-oxoglutarate(out) = glutarate(out) + 2-oxoglutarate(in)

Direction not assertedBalancedTransportRhea 71751

2-oxoheptanedioate(in) + 2-oxoglutarate(out) = 2-oxoheptanedioate(out) + 2-oxoglutarate(in)

Direction not assertedBalancedTransportRhea 71755

heptanedioate(in) + 2-oxoglutarate(out) = heptanedioate(out) + 2-oxoglutarate(in)

Direction not assertedBalancedTransportRhea 71759

citrate(in) + 2-oxoglutarate(out) = citrate(out) + 2-oxoglutarate(in)

Direction not assertedBalancedTransportRhea 71763

2 Fe(2+) + NADP(+) + H(+) = 2 Fe(3+) + NADPH

Right to leftBalancedRhea 71767

2 Cu(+) + NADP(+) + H(+) = 2 Cu(2+) + NADPH

Right to leftBalancedRhea 71771

acetoacetate(out) + H(+)(out) = acetoacetate(in) + H(+)(in)

ReversibleBalancedTransportRhea 71775

4-methyl-2-oxopentanoate(out) + H(+)(out) = 4-methyl-2-oxopentanoate(in) + H(+)(in)

Direction not assertedBalancedTransportRhea 71779

3-methyl-2-oxobutanoate(out) + H(+)(out) = 3-methyl-2-oxobutanoate(in) + H(+)(in)

Direction not assertedBalancedTransportRhea 71783

2-oxoadipate + O2 = (R)-2-hydroxyglutarate + CO2

Direction not assertedBalancedRhea 71787

(R)-lactate(in) + H(+)(in) = (R)-lactate(out) + H(+)(out)

Direction not assertedBalancedTransportRhea 71791

(R)-3-hydroxybutanoate(out) + H(+)(out) = (R)-3-hydroxybutanoate(in) + H(+)(in)

ReversibleBalancedTransportRhea 71795

Ca(2+)(in) + H(+)(out) = Ca(2+)(out) + H(+)(in)

Direction not assertedBalancedTransportRhea 71799

acetate(out) + H(+)(out) = acetate(in) + H(+)(in)

ReversibleBalancedTransportRhea 71803

a 2'-deoxyguanosine in DNA + NAD(+) = an N(2)-(ADP-L-ribosyl)-2'-deoxyguanosine in DNA + nicotinamide + H(+)

Direction not assertedBalance undeterminableRhea 71807

3,3',5-triiodo-L-thyronine(out) = 3,3',5-triiodo-L-thyronine(in)

ReversibleBalancedTransportRhea 71811

3,3',5'-triiodo-L-thyronine(out) = 3,3',5'-triiodo-L-thyronine(in)

Left to rightBalancedTransportRhea 71815

L-thyroxine(out) = L-thyroxine(in)

ReversibleBalancedTransportRhea 71819

3,3'-diiodo-L-thyronine(out) = 3,3'-diiodo-L-thyronine(in)

Direction not assertedBalancedTransportRhea 71823

arsenate(in) + H(+)(in) = arsenate(out) + H(+)(out)

Direction not assertedBalancedTransportRhea 71827

creatine(out) + chloride(out) + 2 Na(+)(out) = creatine(in) + chloride(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71831

estrone 3-sulfate(out) = estrone 3-sulfate(in)

Left to rightBalancedTransportRhea 71835

dehydroepiandrosterone 3-sulfate(out) = dehydroepiandrosterone 3-sulfate(in)

Left to rightBalancedTransportRhea 71839

tauroursodeoxycholate(out) = tauroursodeoxycholate(in)

Direction not assertedBalancedTransportRhea 71843

glycoursodeoxycholate(out) = glycoursodeoxycholate(in)

Direction not assertedBalancedTransportRhea 71847

glycocholate(out) = glycocholate(in)

Right to leftBalancedTransportRhea 71851

taurochenodeoxycholate(out) = taurochenodeoxycholate(in)

Direction not assertedBalancedTransportRhea 71855

glycochenodeoxycholate(out) = glycochenodeoxycholate(in)

Direction not assertedBalancedTransportRhea 71859

taurodeoxycholate(out) = taurodeoxycholate(in)

Direction not assertedBalancedTransportRhea 71863

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