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CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

27,651–27,700 of 31,435, by identifier

substance P + H2O = substance P(1-7) + L-Phe-Gly-L-Leu-L-Met-NH2
Left to rightBalancedRhea 71467
substance P + H2O = L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2 + substance P(1-6)
Left to rightBalancedRhea 71471
neurotensin + H2O = neurotensin(1-11) + L-isoleucyl-L-leucine
Left to rightBalancedRhea 71475
neurotensin + H2O = neurotensin(1-10) + L-tyrosyl-L-isoleucyl-L-leucine
Left to rightBalancedRhea 71479
Met-enkephalin + H2O = L-phenylalanyl-L-methionine + L-tyrosylglycylglycine
Left to rightBalancedRhea 71483
Leu-enkephalin + H2O = L-tyrosylglycylglycine + L-phenylalanyl-L-leucine
Left to rightBalancedRhea 71487
a 6-(alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol(in) = a 6-(alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol(out)

Direction not assertedBalance undeterminableTransportRhea 71491

6-(alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(in) = 6-(alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(out)

Direction not assertedBalancedTransportRhea 71495

6-(N-acetyl-alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(in) = 6-(N-acetyl-alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(out)

Direction not assertedBalancedTransportRhea 71499

a 6-(N-acetyl-alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol(in) = a 6-(N-acetyl-alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol(out)

Direction not assertedBalance undeterminableTransportRhea 71503

(+)-alpha-tocopherol(out) = (+)-alpha-tocopherol(in)

Direction not assertedBalancedTransportRhea 71507

phylloquinone(out) = phylloquinone(in)

Direction not assertedBalancedTransportRhea 71511

hypoxanthine(out) = hypoxanthine(in)

ReversibleBalancedTransportRhea 71515

uridine(out) = uridine(in)

ReversibleBalancedTransportRhea 71519

adenine(out) = adenine(in)

ReversibleBalancedTransportRhea 71523

thymine(out) = thymine(in)

ReversibleBalancedTransportRhea 71527

guanine(out) = guanine(in)

ReversibleBalancedTransportRhea 71531

D-glucose 6-phosphate(in) + phosphate(out) = D-glucose 6-phosphate(out) + phosphate(in)

Direction not assertedBalancedTransportRhea 71535

2 nitrate(out) + H(+)(out) = 2 nitrate(in) + H(+)(in)

Left to rightBalancedTransportRhea 71539

5-hydroxymethyl-dUMP in DNA + ATP = 5-phosphomethyl-dUMP in DNA + ADP + H(+)

Direction not assertedBalancedRhea 71543

5-phosphomethyl-dUMP in DNA + glycine = 5-N(alpha)-glycyl-dTMP in DNA + phosphate

Direction not assertedBalancedRhea 71547

5-N(alpha)-glycyl-dTMP in DNA + AH2 + S-adenosyl-L-methionine = 5-C(alpha)-glycyl-dTMP in DNA + 5'-deoxyadenosine + L-methionine + A + H(+)

Direction not assertedBalancedRhea 71551

5-C(alpha)-glycyl-dTMP in DNA + H(+) = 5-aminoethyl-dUMP in DNA + CO2

Direction not assertedBalancedRhea 71555

5-N(alpha)-glycyl-dTMP in DNA + A + H2O = 5-aminomethyl-dUMP in DNA + glyoxylate + AH2

Direction not assertedBalancedRhea 71559

5-aminomethyl-dUMP in DNA + acetyl-CoA = 5-acetylaminomethyl-dUMP in DNA + CoA + H(+)

Direction not assertedBalancedRhea 71563

5-phosphomethyl-dUMP in DNA + L-serine = 5-O-(L-seryl)-dTMP in DNA + phosphate

Direction not assertedBalancedRhea 71567

5-O-(L-seryl)-dTMP in DNA + H(+) = 5-aminoethoxy-methyl-dUMP in DNA + CO2

Direction not assertedBalancedRhea 71571

5-phosphomethyl-dUMP in DNA + putrescine = 5-N(alpha)-putrescinyl-dTMP in DNA + phosphate

Direction not assertedBalancedRhea 71575

CDP-L-ribitol(in) + CDP(out) = CDP-L-ribitol(out) + CDP(in)

Direction not assertedBalancedTransportRhea 71579

L-histidine(in) + Na(+)(in) = L-histidine(out) + Na(+)(out)

Right to leftBalancedTransportRhea 71583

(S)-malate(in) + 2-oxoglutarate(out) = (S)-malate(out) + 2-oxoglutarate(in)

Direction not assertedBalancedTransportRhea 71587

malonate(in) + 2-oxoglutarate(out) = malonate(out) + 2-oxoglutarate(in)

Direction not assertedBalancedTransportRhea 71591

succinate(in) + 2-oxoglutarate(out) = succinate(out) + 2-oxoglutarate(in)

Direction not assertedBalancedTransportRhea 71595

maleate(in) + 2-oxoglutarate(out) = maleate(out) + 2-oxoglutarate(in)

Direction not assertedBalancedTransportRhea 71599

oxaloacetate(in) + 2-oxoglutarate(out) = oxaloacetate(out) + 2-oxoglutarate(in)

Direction not assertedBalancedTransportRhea 71603

(S)-malate(in) + phosphate(out) = (S)-malate(out) + phosphate(in)

Direction not assertedBalancedTransportRhea 71607

malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)

Direction not assertedBalancedTransportRhea 71611

(S)-malate(in) + sulfate(out) = (S)-malate(out) + sulfate(in)

Direction not assertedBalancedTransportRhea 71615

2 thiosulfate(out) + (S)-malate(in) = 2 thiosulfate(in) + (S)-malate(out)

Direction not assertedBalancedTransportRhea 71619

malonate(out) + phosphate(in) = malonate(in) + phosphate(out)

Direction not assertedBalancedTransportRhea 71623

succinate(out) + phosphate(in) = succinate(in) + phosphate(out)

Direction not assertedBalancedTransportRhea 71627

sulfate(out) + phosphate(in) = sulfate(in) + phosphate(out)

Direction not assertedBalancedTransportRhea 71631

2 thiosulfate(out) + phosphate(in) = 2 thiosulfate(in) + phosphate(out)

Direction not assertedBalancedTransportRhea 71635

K(+)(in) + Na(+)(in) = K(+)(out) + Na(+)(out)

Direction not assertedBalancedTransportRhea 71639

guanosine + NAD(+) = N(2)-(ADP-D-ribosyl)-guanosine + nicotinamide + H(+)

Direction not assertedBalancedRhea 71643

a medium-chain (3S)-3-hydroxyacyl-CoA = a medium-chain (2E)-enoyl-CoA + H2O

Direction not assertedBalance undeterminableRhea 71647

a thymidine in DNA + NAD(+) = an N-(ADP-alpha-D-ribosyl)-thymidine in DNA + nicotinamide + H(+)

Direction not assertedBalance undeterminableRhea 71651

an N-(ADP-alpha-D-ribosyl)-thymidine in DNA + H2O = a thymidine in DNA + ADP-D-ribose

Direction not assertedBalance undeterminableRhea 71655

a D-glucoside + 2 Fe(III)-[cytochrome c] = a 3-dehydro-D-glucoside + 2 Fe(II)-[cytochrome c] + 2 H(+)

Direction not assertedBalance undeterminableRhea 71659

a menaquinone + succinate + 2 H(+)(out) = a menaquinol + fumarate + 2 H(+)(in)

Direction not assertedBalance undeterminableTransportRhea 71663

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