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Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
Interactions
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Reactions
Reach

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Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

27,551–27,600 of 31,435, by identifier

L-arginine(in) + L-phenylalanine(out) = L-arginine(out) + L-phenylalanine(in)
Left to rightBalancedTransportRhea 71067
L-cysteine(out) + L-arginine(in) = L-cysteine(in) + L-arginine(out)
Left to rightBalancedTransportRhea 71071
L-cystine(out) + L-arginine(in) = L-cystine(in) + L-arginine(out)
Left to rightBalancedTransportRhea 71075
cordypyrone A + reduced [NADPH--hemoprotein reductase] + O2 = cordypyrone B + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Direction not assertedBalance undeterminableRhea 71079
estrone 3-sulfate(out) + 2 Na(+)(out) = estrone 3-sulfate(in) + 2 Na(+)(in)
Direction not assertedBalancedTransportRhea 71083
17beta-estradiol 3-sulfate(out) + 2 Na(+)(out) = 17beta-estradiol 3-sulfate(in) + 2 Na(+)(in)
Direction not assertedBalancedTransportRhea 71087

dehydroepiandrosterone 3-sulfate(out) + 2 Na(+)(out) = dehydroepiandrosterone 3-sulfate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71091

pregnenolone sulfate(out) + 2 Na(+)(out) = pregnenolone sulfate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71095

androst-5-ene-diol 3-sulfate(out) + 2 Na(+)(out) = androst-5-ene-diol 3-sulfate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71099

S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)

Direction not assertedBalancedTransportRhea 71103

S-methylmercury-L-cysteine(in) + L-leucine(out) = S-methylmercury-L-cysteine(out) + L-leucine(in)

Direction not assertedBalancedTransportRhea 71107

S-methylmercury-L-cysteine(in) + L-phenylalanine(out) = S-methylmercury-L-cysteine(out) + L-phenylalanine(in)

Direction not assertedBalancedTransportRhea 71111

hispidin + NADH + O2 + H(+) = 3-hydroxyhispidin + NAD(+) + H2O

Direction not assertedBalancedRhea 71115

hispidin + NADPH + O2 + H(+) = 3-hydroxyhispidin + NADP(+) + H2O

Direction not assertedBalancedRhea 71119

(E)-caffeate + 2 malonyl-CoA + ATP + H(+) = hispidin + AMP + 2 CO2 + diphosphate + 2 CoA

Direction not assertedBalancedRhea 71123

L-glutamine(out) + Na(+)(out) + H(+)(in) = L-glutamine(in) + Na(+)(in) + H(+)(out)

ReversibleBalancedTransportRhea 71127

L-asparagine(out) + Na(+)(out) + H(+)(in) = L-asparagine(in) + Na(+)(in) + H(+)(out)

ReversibleBalancedTransportRhea 71131

L-histidine(out) + Na(+)(out) + H(+)(in) = L-histidine(in) + Na(+)(in) + H(+)(out)

ReversibleBalancedTransportRhea 71135

10 malonyl-CoA + acetyl-CoA + 3 AH2 + 8 NADPH + 18 H(+) = cordypyrone A + 3 A + 10 CO2 + 8 NADP(+) + 11 CoA + 8 H2O

Direction not assertedBalancedRhea 71139

3-hydroxyhispidin + O2 = (E)-caffeoylpyruvate + hnu + CO2

Direction not assertedBalance undeterminableRhea 71143

3-hydroxyhispidin + O2 = 4-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-1,7-dihydroxy-2,3,5-trioxabicyclo[2.2.2]oct-7-en-6-one

Direction not assertedBalancedRhea 71147

4-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-1,7-dihydroxy-2,3,5-trioxabicyclo[2.2.2]oct-7-en-6-one = (E)-caffeoylpyruvate + hnu + CO2

Direction not assertedBalance undeterminableRhea 71151

(E)-caffeoylpyruvate + H2O = (E)-caffeate + pyruvate + H(+)

Direction not assertedBalancedRhea 71155

L-serine(out) + Na(+)(out) + H(+)(in) = L-serine(in) + Na(+)(in) + H(+)(out)

ReversibleBalancedTransportRhea 71159

L-alanine(out) + Na(+)(out) + H(+)(in) = L-alanine(in) + Na(+)(in) + H(+)(out)

ReversibleBalancedTransportRhea 71163

glycine(out) + Na(+)(out) + H(+)(in) = glycine(in) + Na(+)(in) + H(+)(out)

ReversibleBalancedTransportRhea 71167

L-cysteine(out) + Na(+)(out) + H(+)(in) = L-cysteine(in) + Na(+)(in) + H(+)(out)

ReversibleBalancedTransportRhea 71171

glycine betaine(out) + 2 chloride(out) + 3 Na(+)(out) = glycine betaine(in) + 2 chloride(in) + 3 Na(+)(in)

Left to rightBalancedTransportRhea 71175

L-histidine(out) + L-tryptophan(in) = L-histidine(in) + L-tryptophan(out)

Direction not assertedBalancedTransportRhea 71179

L-kynurenine(out) + L-tryptophan(in) = L-kynurenine(in) + L-tryptophan(out)

Direction not assertedBalancedTransportRhea 71183

3-hydroxy-L-kynurenine(out) + L-tryptophan(in) = 3-hydroxy-L-kynurenine(in) + L-tryptophan(out)

Direction not assertedBalancedTransportRhea 71187

an L-alpha-amino acid(in) + L-kynurenine(out) = an L-alpha-amino acid(out) + L-kynurenine(in)

Direction not assertedBalance undeterminableTransportRhea 71191

Zn(2+)(out) + H(+)(out) = Zn(2+)(in) + H(+)(in)

Left to rightBalancedTransportRhea 71195

L-ornithine(in) = L-ornithine(out)

Direction not assertedBalancedTransportRhea 71199

L-homoarginine(in) = L-homoarginine(out)

Direction not assertedBalancedTransportRhea 71203

iodide(out) + 2 Na(+)(out) = iodide(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71207

chlorate(out) + 2 Na(+)(out) = chlorate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71211

thiocyanate(out) + 2 Na(+)(out) = thiocyanate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71215

nitrate(out) + 2 Na(+)(out) = nitrate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71219

taurine(out) + chloride(out) + 2 Na(+)(out) = taurine(in) + chloride(in) + 2 Na(+)(in)

Left to rightBalancedTransportRhea 71223

selenocyanate(out) + 2 Na(+)(out) = selenocyanate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71227

2 Fe(3+)-[Dph3] + NADH = 2 Fe(2+)-[Dph3] + NAD(+) + H(+)

Direction not assertedBalance undeterminableRhea 71231

[3Fe-4S](1+)-[protein] + Fe(2+)-[Dph3] = [3Fe-4S](0)-[protein] + Fe(3+)-[Dph3]

Direction not assertedBalance undeterminableRhea 71235

2 [3Fe-4S](0)-[protein] + 2 Fe(2+)-[Dph3] + NADH = 2 [4Fe-4S](1+)-[protein] + 2 [Dph3] + NAD(+) + H(+)

Direction not assertedBalance undeterminableRhea 71239

hypotaurine(out) + chloride(out) + 2 Na(+)(out) = hypotaurine(in) + chloride(in) + 2 Na(+)(in)

Left to rightBalancedTransportRhea 71243

beta-alanine(out) + chloride(out) + 2 Na(+)(out) = beta-alanine(in) + chloride(in) + 2 Na(+)(in)

Left to rightBalancedTransportRhea 71247

L-xylopyranose = L-xylulose

Direction not assertedBalancedRhea 71251

3 Na(+)(out) + phosphate(out) = 3 Na(+)(in) + phosphate(in)

Left to rightBalancedTransportRhea 71255

2 Na(+)(out) + phosphate(out) = 2 Na(+)(in) + phosphate(in)

Left to rightBalancedTransportRhea 71259

L-proline(out) + chloride(out) + 2 Na(+)(out) = L-proline(in) + chloride(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71263

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