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ReactionsRhea and Human-GEM, by subsystem
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Reference

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

27,301–27,350 of 31,435, by identifier

a C28-steroid + reduced [NADPH--hemoprotein reductase] + O2 = a (22S)-22-hydroxy C28-steroid + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Direction not assertedBalance undeterminableRhea 70063
a C29-steroid + reduced [NADPH--hemoprotein reductase] + O2 = a (22S)-22-hydroxy C29-steroid + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Direction not assertedBalance undeterminableRhea 70067
sitosterol + reduced [NADPH--hemoprotein reductase] + O2 = (22S)-22-hydroxysitosterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Direction not assertedBalance undeterminableRhea 70071
3 malonyl-CoA + acetyl-CoA + AH2 + 2 S-adenosyl-L-methionine + H(+) = clavatol + A + 2 S-adenosyl-L-homocysteine + 3 CO2 + 4 CoA + H2O
Direction not assertedBalancedRhea 70075
clavatol + 2-oxoglutarate + O2 = hydroxyclavatol + succinate + CO2
Direction not assertedBalancedRhea 70079
hydroxyclavatol = o-quinone methide + H2O
Direction not asserted

?

Balanced

Rhea 70083

o-quinone methide + methanol = hydroxyclavatol methyl ether

Direction not assertedBalancedRhea 70087

o-quinone methide + ethanol = hydroxyclavatol ethyl ether

Direction not assertedBalancedRhea 70091

(R)-5-methyl-tetronate + o-quinone methide = peniphenone D

Direction not assertedBalancedRhea 70095

peniphenone D + o-quinone methide + H(+) = penilactone A

Direction not assertedBalancedRhea 70099

penilactone D + o-quinone methide + H(+) = penilactone B

Direction not assertedBalancedRhea 70103

(S)-5-carboxymethyl-tetronate + o-quinone methide = penilactone D + H(+)

Direction not assertedBalancedRhea 70107

6-deoxo-28-norteasterone + 2 reduced [NADPH--hemoprotein reductase] + 2 O2 = 28-norteasterone + 2 oxidized [NADPH--hemoprotein reductase] + 3 H2O + 2 H(+)

Direction not assertedBalance undeterminableRhea 70111

6-deoxo-28-norteasterone + reduced [NADPH--hemoprotein reductase] + O2 = 6alpha-hydroxy-28-norteasterone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 70115

6alpha-hydroxy-28-norteasterone + reduced [NADPH--hemoprotein reductase] + O2 = 28-norteasterone + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)

Direction not assertedBalance undeterminableRhea 70119

3-dehydro-6-deoxo-28-norteasterone + 2 reduced [NADPH--hemoprotein reductase] + 2 O2 = 6-dehydro-28-norteasterone + 2 oxidized [NADPH--hemoprotein reductase] + 3 H2O + 2 H(+)

Direction not assertedBalance undeterminableRhea 70123

3-dehydro-6-deoxo-28-norteasterone + reduced [NADPH--hemoprotein reductase] + O2 = 3-dehydro-6alpha-hydroxy-28-norteasterone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 70127

3-dehydro-6alpha-hydroxy-28-norteasterone + reduced [NADPH--hemoprotein reductase] + O2 = 6-dehydro-28-norteasterone + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)

Direction not assertedBalance undeterminableRhea 70131

6-deoxo-28-nortyphasterol + 2 reduced [NADPH--hemoprotein reductase] + 2 O2 = 28-nortyphasterol + 2 oxidized [NADPH--hemoprotein reductase] + 3 H2O + 2 H(+)

Direction not assertedBalance undeterminableRhea 70135

6-deoxo-28-nortyphasterol + reduced [NADPH--hemoprotein reductase] + O2 = 6alpha-hydroxy-28-nortyphasterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 70139

6alpha-hydroxy-28-nortyphasterol + reduced [NADPH--hemoprotein reductase] + O2 = 28-nortyphasterol + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)

Direction not assertedBalance undeterminableRhea 70143

6-deoxo-28-norcastasterone + 2 reduced [NADPH--hemoprotein reductase] + 2 O2 = 28-norcastasterone + 2 oxidized [NADPH--hemoprotein reductase] + 3 H2O + 2 H(+)

Direction not assertedBalance undeterminableRhea 70147

6-deoxo-28-norcastasterone + reduced [NADPH--hemoprotein reductase] + O2 = 6alpha-hydroxy-28-norcastasterone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 70151

6alpha-hydroxy-28-norcastasterone + reduced [NADPH--hemoprotein reductase] + O2 = 28-norcastasterone + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)

Direction not assertedBalance undeterminableRhea 70155

folate(in) + H(+)(in) = folate(out) + H(+)(out)

Direction not assertedBalancedTransportRhea 70159

methotrexate(in) + H(+)(in) = methotrexate(out) + H(+)(out)

Direction not assertedBalancedTransportRhea 70163

(6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + H(+)(in) = (6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + H(+)(out)

Direction not assertedBalancedTransportRhea 70167

pemetrexed(in) + H(+)(in) = pemetrexed(out) + H(+)(out)

Direction not assertedBalancedTransportRhea 70171

beta-D-glucosyl-(1->4)-D-galactose + phosphate = D-galactose + alpha-D-glucose 1-phosphate

Direction not assertedBalancedRhea 70175

2 D-maltotetraose = alpha-isomaltosyl-(1->4)-D-maltotriose + D-maltotriose

Direction not assertedBalancedRhea 70179

2 alpha-isomaltosyl-(1->4)-D-maltotriose = alpha-isomaltosyl-(1->3)-alpha-isomaltosyl-(1->4)-D-maltotriose + D-maltotriose

Direction not assertedBalancedRhea 70183

alpha-isomaltosyl-(1->3)-alpha-isomaltosyl-(1->4)-D-maltotriose = cyclobis-(1->3)-alpha-D-isomaltosyl + D-maltotriose

Direction not assertedBalancedRhea 70187

NAD(+) + ATP = 3'-NADP(+) + ADP + H(+)

Direction not assertedBalancedRhea 70191

deamido-NAD(+) + ATP = nicotinate-adenine dinucleotide 3'-phosphate + ADP + H(+)

Direction not assertedBalancedRhea 70195

dopaminechrome = 5,6-dihydroxyindole

Direction not assertedBalancedRhea 70199

N-methyldopaminechrome = 5,6-dihydroxyindole-N-methyl

Direction not assertedBalancedRhea 70203

sphinga-4E,14Z-dienine-1-phosphate(in) = sphinga-4E,14Z-dienine-1-phosphate(out)

Direction not assertedBalancedTransportRhea 70207

GDP-D-glycero-alpha-D-manno-heptose + 2-oxoglutarate = GDP-D-glycero-4-keto-alpha-D-lyxo-heptose + (S)-2-hydroxyglutarate

Direction not assertedBalancedRhea 70211

cortisol + NADPH + H(+) = 20beta-dihydrocortisol + NADP(+)

Left to rightBalancedRhea 70215

corticosterone + NADPH + H(+) = 20beta-dihydrocorticosterone + NADP(+)

Left to rightBalancedRhea 70219

(2S)-2-aminobutanoate + 2-oxoglutarate = 2-oxobutanoate + L-glutamate

Right to leftBalancedRhea 70223

(2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA = (E)-2-benzylidenesuccinyl-CoA + H2O

Direction not assertedBalancedRhea 70227

(2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA + NAD(+) = (S)-2-benzoylsuccinyl-CoA + NADH + H(+)

Direction not assertedBalancedRhea 70231

a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-galactoside + an N-acylsphing-4-enine

ReversibleBalance undeterminableRhea 70235

a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-xyloside + an N-acylsphing-4-enine

ReversibleBalance undeterminableRhea 70239

UDP-alpha-D-xylose + an N-acylsphing-4-enine = a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + UDP + H(+)

Left to rightBalance undeterminableRhea 70243

N-(9Z-octadecenoyl)-sphing-4-enine + UDP-alpha-D-xylose = beta-D-xylosyl-(1<->1')-N-(9Z-octadecenoyl)-sphing-4-enine + UDP + H(+)

Left to rightBalancedRhea 70247

beta-D-xylosyl-(1<->1')-N-(9Z-octadecenoyl)-sphing-4-enine + cholesterol = cholesteryl 3-beta-D-xyloside + N-(9Z-octadecenoyl)-sphing-4-enine

Left to rightBalancedRhea 70251

1-(beta-D-galactosyl)-N-dodecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-galactoside + N-dodecanoylsphing-4-enine

ReversibleBalancedRhea 70255

AMP(out) + phosphate(in) = AMP(in) + phosphate(out)

Direction not assertedBalancedTransportRhea 70259

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