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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Proteins
Interactions
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Reactions
Reach

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Cell types
Organisms
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

27,001–27,050 of 31,435, by identifier

(2Z,6E)-farnesyl diphosphate = (E)-beta-farnesene + diphosphate
Direction not assertedBalancedRhea 68856
7-oxo-25-hydroxycholesterol + NADPH + H(+) = 7beta-25-dihydroxycholesterol + NADP(+)
Direction not assertedBalancedRhea 68860
isomaltose + H2O = alpha-D-glucose + D-glucose
Left to rightBalancedRhea 68864
benzoate + ATP + NADPH + H(+) = benzaldehyde + AMP + diphosphate + NADP(+)
Direction not assertedBalancedRhea 68868
(E)-cinnamate + ATP + NADPH + H(+) = (E)-cinnamaldehyde + AMP + diphosphate + NADP(+)
Direction not assertedBalancedRhea 68872
piperonylate + ATP + NADPH + H(+) = piperonal + AMP + diphosphate + NADP(+)
Direction not assertedBalancedRhea 68876
salicylate + ATP + NADPH + H(+) = salicylaldehyde + AMP + diphosphate + NADP(+)

Direction not assertedBalancedRhea 68880

3-hydroxybenzoate + ATP + NADPH + H(+) = 3-hydroxybenzaldehyde + AMP + diphosphate + NADP(+)

Direction not assertedBalancedRhea 68884

2-methoxybenzoate + ATP + NADPH + H(+) = 2-methoxybenzaldehyde + AMP + diphosphate + NADP(+)

Direction not assertedBalancedRhea 68888

3-methoxybenzoate + ATP + NADPH + H(+) = 3-methoxybenzaldehyde + AMP + diphosphate + NADP(+)

Direction not assertedBalancedRhea 68892

4-hydroxybenzoate + ATP + NADPH + H(+) = 4-hydroxybenzaldehyde + AMP + diphosphate + NADP(+)

Direction not assertedBalancedRhea 68896

4-methoxybenzoate + ATP + NADPH + H(+) = 4-methoxybenzaldehyde + AMP + diphosphate + NADP(+)

Direction not assertedBalancedRhea 68900

3-phenylpropanoate + ATP + NADPH + H(+) = 3-phenylpropanal + AMP + diphosphate + NADP(+)

Direction not assertedBalancedRhea 68904

picolinate + ATP + NADPH + H(+) = picolinal + AMP + diphosphate + NADP(+)

Direction not assertedBalancedRhea 68908

propanoate + ATP + NADPH + H(+) = propanal + AMP + diphosphate + NADP(+)

Direction not assertedBalancedRhea 68912

butanoate + ATP + NADPH + H(+) = butanal + AMP + diphosphate + NADP(+)

Direction not assertedBalancedRhea 68916

pentanoate + ATP + NADPH + H(+) = pentanal + AMP + diphosphate + NADP(+)

Direction not assertedBalancedRhea 68920

hexanoate + ATP + NADPH + H(+) = hexanal + AMP + diphosphate + NADP(+)

Direction not assertedBalancedRhea 68924

heptanoate + ATP + NADPH + H(+) = heptanal + AMP + diphosphate + NADP(+)

Direction not assertedBalancedRhea 68928

octanoate + ATP + NADPH + H(+) = octanal + AMP + diphosphate + NADP(+)

Direction not assertedBalancedRhea 68932

nonanoate + ATP + NADPH + H(+) = nonanal + AMP + diphosphate + NADP(+)

Direction not assertedBalancedRhea 68936

tellurite(in) + Na(+)(in) = tellurite(out) + Na(+)(out)

Direction not assertedBalancedTransportRhea 68940

esculetin + S-adenosyl-L-methionine = isoscopoletin + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 68944

esculetin + S-adenosyl-L-methionine = scopoletin + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 68948

isoscopoletin + S-adenosyl-L-methionine = scoparone + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 68952

scopoletin + S-adenosyl-L-methionine = scoparone + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 68956

7,8-dihydroxycoumarin + S-adenosyl-L-methionine = 7-hydroxy-8-methoxycoumarin + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 68960

2-hydroxyoctadecanoate + O2 = 2-oxooctadecanoate + H2O2

Direction not assertedBalancedRhea 68964

mandelate + O2 = phenylglyoxylate + H2O2

Direction not assertedBalancedRhea 68968

sn-glycerol 3-phosphate + A = dihydroxyacetone phosphate + AH2

Direction not assertedBalancedRhea 68972

glycoursodeoxycholate + NADP(+) = 7-oxoglycolithocholate + NADPH + H(+)

Right to leftBalancedRhea 68976

tauroursodeoxycholate + NADP(+) = 7-oxotaurolithocholate + NADPH + H(+)

Right to leftBalancedRhea 68980

a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine + ATP + H2O = a 5-methyl-2'-deoxycytidine in DNA + S-adenosyl-L-homocysteine + ADP + phosphate + 2 H(+)

Direction not assertedBalance undeterminableRhea 68984

1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine

ReversibleBalancedRhea 68988

3-amino-4-hydroxybenzoate + NADPH + O2 + H(+) = 3-amino-2,4-dihydroxybenzoate + NADP(+) + H2O

Direction not assertedBalancedRhea 68992

gibberellin A9 + 2-oxoglutarate + O2 = gibberellin A4 + succinate + CO2

Direction not assertedBalancedRhea 68996

3-amino-2,4-dihydroxybenzoate + S-adenosyl-L-methionine = 3-amino-2-hydroxy-4-methoxybenzoate + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 69000

3-amino-2-hydroxy-4-methoxybenzoate + nitrite + ATP = cremeomycin + AMP + diphosphate + H2O

Direction not assertedBalancedRhea 69004

L-aspartate + 3 NADPH + 3 O2 + 2 H(+) = 2-nitrobutanedioate + 3 NADP(+) + 4 H2O

Direction not assertedBalancedRhea 69008

5beta-dihydrotestosterone + NADPH + H(+) = 5beta-androstane-3beta,17beta-diol + NADP(+)

Left to rightBalancedRhea 69012

3alpha-hydroxy-5beta-pregnan-20-one + NADP(+) = 5beta-pregnan-3,20-dione + NADPH + H(+)

Right to leftBalancedRhea 69016

L-aspartate + NADPH + O2 = N-hydroxy-L-aspartate + NADP(+) + H2O

Direction not assertedBalancedRhea 69020

N-hydroxy-L-aspartate + NADPH + O2 + H(+) = N,N-dihydroxy-L-aspartate + NADP(+) + H2O

Direction not assertedBalancedRhea 69024

5beta-dihydrotestosterone + NADPH + H(+) = 5beta-androstane-3alpha,17beta-diol + NADP(+)

Direction not assertedBalancedRhea 69028

N,N-dihydroxy-L-aspartate = (2S)-2-nitrosobutanedioate + H2O

Direction not assertedBalancedRhea 69032

5beta-androstane-3,17-dione + NADPH + H(+) = 3beta-hydroxy-5beta-androstane-17-one + NADP(+)

Left to rightBalancedRhea 69036

(2S)-2-nitrosobutanedioate + NADPH + O2 + H(+) = 2-nitrobutanedioate + NADP(+) + H2O

Direction not assertedBalancedRhea 69040

2-nitrobutanedioate = fumarate + nitrite + H(+)

Direction not assertedBalancedRhea 69044

hexano-6-lactone + H2O = 6-hydroxyhexanoate + H(+)

Direction not assertedBalancedRhea 69048

N(omega)-methyl-L-arginine + 2 NADH + 3 O2 + H(+) = N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline + 2 NAD(+) + 3 H2O

Direction not assertedBalancedRhea 69052

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