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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Reactions
Reach

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

26,851–26,900 of 31,435, by identifier

L-cystine(in) + Na(+)(in) = L-cystine(out) + Na(+)(out)
Direction not assertedBalancedTransportRhea 68256
D-serine(out) + 2 Na(+)(out) = D-serine(in) + 2 Na(+)(in)
Direction not assertedBalancedTransportRhea 68260
(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H2O = (6S)-5,6,7,8-tetrahydrofolate + formaldehyde
Direction not assertedBalancedRhea 68264
dUMP + formaldehyde + NADPH + H(+) = dTMP + NADP(+) + H2O
Direction not assertedBalancedRhea 68268
L-seryl-[protein] + a fatty acyl-CoA = O-fatty acyl-L-seryl-[protein] + CoA
Left to rightBalance undeterminableRhea 68272
L-seryl-[protein] + butanoyl-CoA = O-butanoyl-L-seryl-[protein] + CoA
Left to rightBalance undeterminableRhea 68276
pentanoyl-CoA + L-seryl-[protein] = O-pentanoyl-L-seryl-[protein] + CoA

Left to rightBalance undeterminableRhea 68280

hexanoyl-CoA + L-seryl-[protein] = O-hexanoyl-L-seryl-[protein] + CoA

Left to rightBalance undeterminableRhea 68284

heptanoyl-CoA + L-seryl-[protein] = O-heptanoyl-L-seryl-[protein] + CoA

Left to rightBalance undeterminableRhea 68288

nonanoyl-CoA + L-seryl-[protein] = O-nonanoyl-L-seryl-[protein] + CoA

Left to rightBalance undeterminableRhea 68292

L-seryl-[protein] + dodecanoyl-CoA = O-dodecanoyl-L-seryl-[protein] + CoA

Left to rightBalance undeterminableRhea 68296

L-seryl-[protein] + tetradecanoyl-CoA = O-tetradecanoyl-L-seryl-[protein] + CoA

Left to rightBalance undeterminableRhea 68300

3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + 3'-phosphoadenylyl sulfate = 3-O-{O-3-S-beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + adenosine 3',5'-bisphosphate + H(+)

Left to rightBalance undeterminableRhea 68304

1D-myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,3,4,5-pentakisphosphate + phosphate

Direction not assertedBalancedRhea 68308

1D-myo-inositol 1,2,3,4,5-pentakisphosphate + H2O = 1D-myo-inositol 2,3,4,5-tetrakisphosphate + phosphate

Direction not assertedBalancedRhea 68312

1D-myo-inositol 2,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 2,4,5-triphosphate + phosphate

Direction not assertedBalancedRhea 68316

1D-myo-inositol 2,4,5-triphosphate + H2O = 1D-myo-inositol 2,5-bisphosphate + phosphate

Direction not assertedBalancedRhea 68320

1D-myo-inositol 2,5-bisphosphate + H2O = 1D-myo-inositol 2-phosphate + phosphate

Direction not assertedBalancedRhea 68324

(R)-4'-phosphopantetheine + H2O = (R)-pantetheine + phosphate

Left to rightBalancedRhea 68328

(R)-4'-phosphopantothenate + H2O = (R)-pantothenate + phosphate

Direction not assertedBalancedRhea 68332

(R)-4'-phosphopantetheine sulfonate + H2O = (R)-pantetheine sulfonate + phosphate

Left to rightBalancedRhea 68336

(R)-4'-phospho-S-sulfopantetheine + H2O = (R)-S-sulfopantetheine + phosphate

Left to rightBalancedRhea 68340

GTP + ATP = 3',2'-cGAMP + 2 diphosphate

Direction not assertedBalancedRhea 68344

GTP + ATP = pppA(2'-5')pG + diphosphate

Direction not assertedBalancedRhea 68348

pppA(2'-5')pG = 3',2'-cGAMP + diphosphate

Direction not assertedBalancedRhea 68352

N-acetyl-L-aspartyl-L-glutamate + H2O = N-acetyl-L-aspartate + L-glutamate

Direction not assertedBalancedRhea 68356

L-xylono-1,4-lactone + O2 = dehydro-L-arabinono-1,4-lactone + H2O2 + H(+)

Direction not assertedBalancedRhea 68360

4-CDP-2-C-methyl-D-erythritol = 2-C-methyl-D-erythritol 3,4-cyclophosphate + CMP + H(+)

Direction not assertedBalancedRhea 68364

3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + UDP-alpha-D-xylose = 3-O-{(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n+1)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + UDP + H(+)

Left to rightBalance undeterminableRhea 68368

L-asparagine + pyruvate = 2-oxosuccinamate + L-alanine

Direction not assertedBalancedRhea 68372

L-asparagine + glyoxylate = 2-oxosuccinamate + glycine

Direction not assertedBalancedRhea 68376

3-hydroxypyruvate + L-asparagine = 2-oxosuccinamate + L-serine

Direction not assertedBalancedRhea 68380

L-tryptophyl-[protein] + (2E,6E)-farnesyl diphosphate = (2S,3R)-3-farnesyl-2,3-dihydro-2,N(alpha)-cyclo-L-tryptophyl-[protein] + diphosphate

Direction not assertedBalance undeterminableRhea 68384

2 5,6-dihydroxyindole-2-carboxylate + O2 = 2 indole-5,6-quinone-2-carboxylate + 2 H2O

Left to rightBalancedRhea 68388

peracetic acid + H2O = acetate + H2O2 + H(+)

Direction not assertedBalancedRhea 68392

a percarboxylic acid + H2O = a carboxylate + H2O2 + H(+)

Direction not assertedBalance undeterminableRhea 68396

(2E,6E)-farnesyl diphosphate = gamma-gurjunene + diphosphate

Direction not assertedBalancedRhea 68400

(2R,3S)-iso(homo)2citrate + NAD(+) = 2-oxoheptanedioate + CO2 + NADH

Direction not assertedBalancedRhea 68404

(2R,3S)-iso(homo)3citrate + NAD(+) = 2-oxosuberate + CO2 + NADH

Direction not assertedBalancedRhea 68408

L-glutamate 5-semialdehyde + NADP(+) + H2O = L-glutamate + NADPH + 2 H(+)

Direction not assertedBalancedRhea 68412

cis-(homo)2aconitate + H2O = (2R,3S)-iso(homo)2citrate

Direction not assertedBalancedRhea 68416

cis-(homo)3aconitate + H2O = (2R,3S)-iso(homo)3citrate

Direction not assertedBalancedRhea 68420

(3R)-3-hydroxy-10'-apo-beta-carotenal + O2 = 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial + (3R)-hydroxy-beta-ionone

Left to rightBalancedRhea 68424

lutein + O2 = (3R,6R)-hydroxy-alpha-ionone + (3R)-3-hydroxy-10'-apo-beta-carotenal

Left to rightBalancedRhea 68428

lutein + O2 = (3R,6R)-3-hydroxy-10'-apo-alpha-carotenal + (3R)-hydroxy-beta-ionone

Left to rightBalancedRhea 68432

(3R,6R)-3-hydroxy-10'-apo-alpha-carotenal + O2 = (3R,6R)-hydroxy-alpha-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial

Left to rightBalancedRhea 68436

beta-cryptoxanthin + O2 = all-trans-10'-apo-beta-carotenal + (3R)-hydroxy-beta-ionone

Left to rightBalancedRhea 68440

5-cis-lycopene + O2 = 5-cis-10'-apo-lycopenal + (3E,5E)-6,10-dimethylundeca-3,5,9-trien-2-one

Left to rightBalancedRhea 68444

13-cis-lycopene + O2 = 13-cis-10'-apo-lycopenal + (3E,5E)-6,10-dimethylundeca-3,5,9-trien-2-one

Left to rightBalancedRhea 68448

all-trans-10'-apo-beta-carotenal + O2 = beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial

Left to rightBalancedRhea 68452

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