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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
Interactions
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Reactions
Reach

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Cell types
Organisms
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

26,301–26,350 of 31,435, by identifier

(9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
Direction not assertedBalance undeterminableRhea 66040
2-oxobutanoate + L-kynurenine = (2S)-2-aminobutanoate + kynurenate + H2O
Left to rightBalancedRhea 66044
2-oxobutanoate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + (2S)-2-aminobutanoate
Direction not assertedBalancedRhea 66048
indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
Left to rightBalancedRhea 66052
indole-3-pyruvate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-tryptophan
Direction not assertedBalancedRhea 66056
2-oxohexanoate + L-kynurenine = L-2-aminohexanoate + kynurenate + H2O
Left to rightBalancedRhea 66060
2-oxohexanoate + L-kynurenine = L-2-aminohexanoate + 4-(2-aminophenyl)-2,4-dioxobutanoate

Direction not assertedBalancedRhea 66064

4-methyl-2-oxopentanoate + L-kynurenine = kynurenate + L-leucine + H2O

Left to rightBalancedRhea 66068

4-methyl-2-oxopentanoate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-leucine

Direction not assertedBalancedRhea 66072

2-oxopentanoate + L-kynurenine = L-2-aminopentanoate + kynurenate + H2O

Left to rightBalancedRhea 66076

2-oxopentanoate + L-kynurenine = L-2-aminopentanoate + 4-(2-aminophenyl)-2,4-dioxobutanoate

Direction not assertedBalancedRhea 66080

L-kynurenine + oxaloacetate = kynurenate + L-aspartate + H2O

Direction not assertedBalancedRhea 66084

L-kynurenine + oxaloacetate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-aspartate

Direction not assertedBalancedRhea 66088

3-phenylpyruvate + L-kynurenine = kynurenate + L-phenylalanine + H2O

Left to rightBalancedRhea 66092

3-phenylpyruvate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-phenylalanine

Direction not assertedBalancedRhea 66096

3-(4-hydroxyphenyl)pyruvate + L-kynurenine = kynurenate + L-tyrosine + H2O

Direction not assertedBalancedRhea 66100

3-(4-hydroxyphenyl)pyruvate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-tyrosine

Direction not assertedBalancedRhea 66104

2-oxobutanoate + L-cysteine = 2-oxo-3-sulfanylpropanoate + (2S)-2-aminobutanoate

Direction not assertedBalancedRhea 66108

2-oxobutanoate + L-tyrosine = (2S)-2-aminobutanoate + 3-(4-hydroxyphenyl)pyruvate

Direction not assertedBalancedRhea 66112

2-oxobutanoate + L-glutamine = 2-oxoglutaramate + (2S)-2-aminobutanoate

Direction not assertedBalancedRhea 66116

2-oxobutanoate + L-methionine = (2S)-2-aminobutanoate + 4-methylsulfanyl-2-oxobutanoate

Direction not assertedBalancedRhea 66120

2-oxobutanoate + L-histidine = 3-(imidazol-5-yl)pyruvate + (2S)-2-aminobutanoate

Direction not assertedBalancedRhea 66124

2-oxobutanoate + L-phenylalanine = (2S)-2-aminobutanoate + 3-phenylpyruvate

Direction not assertedBalancedRhea 66128

a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)

Left to rightBalance undeterminableTransportRhea 66132

tyramine + acetyl-CoA = N-acetyltyramine + CoA + H(+)

Direction not assertedBalancedRhea 66136

octopamine + acetyl-CoA = N-acetyloctopamine + CoA + H(+)

Direction not assertedBalancedRhea 66140

5-methoxytryptamine + acetyl-CoA = melatonin + CoA + H(+)

Direction not assertedBalancedRhea 66144

2-phenylethylamine + acetyl-CoA = N-(2-phenylethyl)acetamide + CoA + H(+)

Direction not assertedBalancedRhea 66148

noradrenaline + acetyl-CoA = N-acetylnoradrenaline + CoA + H(+)

Direction not assertedBalancedRhea 66152

tyramine + butanoyl-CoA = N-butanoyltyramine + CoA + H(+)

Direction not assertedBalancedRhea 66156

tyramine + hexanoyl-CoA = N-hexanoyltyramine + CoA + H(+)

Direction not assertedBalancedRhea 66160

serotonin + butanoyl-CoA = N-butanoylserotonin + CoA + H(+)

Direction not assertedBalancedRhea 66164

[protein]-with a C-terminal TM segment(out) + ATP + H2O = [protein]-with a C-terminal TM segment(in) + ADP + phosphate + H(+)

Direction not assertedBalance undeterminableTransportRhea 66168

L-cystine(out) + H(+)(out) = L-cystine(in) + H(+)(in)

Left to rightBalancedTransportRhea 66172

taurochenodeoxycholate 3-sulfate(in) + ATP + H2O = taurochenodeoxycholate 3-sulfate(out) + ADP + phosphate + H(+)

Left to rightBalancedTransportRhea 66176

(4Z,15Z)-bilirubin IXalpha C8-beta-D-glucuronoside(in) + ATP + H2O = (4Z,15Z)-bilirubin IXalpha C8-beta-D-glucuronoside(out) + ADP + phosphate + H(+)

Left to rightBalancedTransportRhea 66180

3',5'-cyclic AMP(in) + ATP + H2O = 3',5'-cyclic AMP(out) + ADP + phosphate + H(+)

Left to rightBalancedTransportRhea 66184

3',5'-cyclic GMP(in) + ATP + H2O = 3',5'-cyclic GMP(out) + ADP + phosphate + H(+)

Left to rightBalancedTransportRhea 66188

(4Z,15Z)-bilirubin IXalpha C8,C12-beta-D-bisglucuronoside(in) + ATP + H2O = (4Z,15Z)-bilirubin IXalpha C8,C12-beta-D-bisglucuronoside(out) + ADP + phosphate + H(+)

Left to rightBalancedTransportRhea 66192

tryptamine + acetyl-CoA = N-acetyltryptamine + CoA + H(+)

Direction not assertedBalancedRhea 66196

pentanoyl-CoA + O2 = (2E)-pentenoyl-CoA + H2O2

Direction not assertedBalancedRhea 66200

heptanoyl-CoA + O2 = (2E)-heptenoyl-CoA + H2O2

Direction not assertedBalancedRhea 66204

(8R)-8-hydroxynonanoyl-CoA + O2 = (2E,8R)-8-hydroxynonenoyl-CoA + H2O2

Direction not assertedBalancedRhea 66208

asc-omegaC5-CoA + O2 = asc-omegaDeltaC5-CoA + H2O2

Direction not assertedBalancedRhea 66212

asc-C7-CoA + O2 = asc-DeltaC7-CoA + H2O2

Direction not assertedBalancedRhea 66216

asc-omegaC7-CoA + O2 = asc-omegaDeltaC7-CoA + H2O2

Direction not assertedBalancedRhea 66220

asc-C9-CoA + O2 = asc-DeltaC9-CoA + H2O2

Direction not assertedBalancedRhea 66224

asc-C13-CoA + O2 = asc-DeltaC13-CoA + H2O2

Direction not assertedBalancedRhea 66228

IC-asc-C7-CoA + O2 = IC-asc-DeltaC7-CoA + H2O2

Direction not assertedBalancedRhea 66232

IC-asc-C9-CoA + O2 = IC-asc-DeltaC9-CoA + H2O2

Direction not assertedBalancedRhea 66236

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