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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Proteins
Interactions
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Reactions
Reach

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

26,351–26,400 of 31,435, by identifier

IC-asc-C9 + ATP + CoA = IC-asc-C9-CoA + AMP + diphosphate
Direction not assertedBalancedRhea 66240
IC-asc-C9 + ATP + H(+) = IC-asc-C9-AMP + diphosphate
Direction not assertedBalancedRhea 66244
IC-asc-C9-AMP + CoA = IC-asc-C9-CoA + AMP + H(+)
Direction not assertedBalancedRhea 66248
IC-asc-C7 + ATP + CoA = IC-asc-C7-CoA + AMP + diphosphate
Direction not assertedBalancedRhea 66252
IC-asc-C7 + ATP + H(+) = IC-asc-C7-AMP + diphosphate
Direction not assertedBalancedRhea 66256
IC-asc-C7-AMP + CoA = IC-asc-C7-CoA + AMP + H(+)
Direction not assertedBalancedRhea 66260
nonanoate + ATP + H(+) = nonanoyl-AMP + diphosphate

? Direction not asserted

Balanced

Rhea 66264

nonanoyl-AMP + CoA = nonanoyl-CoA + AMP + H(+)

Direction not assertedBalancedRhea 66268

a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ADP + phosphate + H(+)

Left to rightBalance undeterminableTransportRhea 66272

tigogenin + UDP-alpha-D-glucose = tigogenin 3-O-beta-D-glucopyranoside + UDP + H(+)

Direction not assertedBalancedRhea 66276

solanidine + UDP-alpha-D-glucose = solanidine 3-O-beta-D-glucopyranoside + UDP + H(+)

Direction not assertedBalancedRhea 66280

tomatidine + UDP-alpha-D-glucose = tomatidine 3-O-beta-D-glucopyranoside + UDP + H(+)

Direction not assertedBalancedRhea 66284

an alpha-D-mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) = an inositol-1-phospho-D-mannosyl-alpha-1->6-inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + a 1,2-diacyl-sn-glycerol

Direction not assertedBalance undeterminableRhea 66288

an inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose = an alpha-D-mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP + H(+)

Direction not assertedBalance undeterminableRhea 66292

an inositol-1-phosphodihydroceramide + GDP-alpha-D-mannose = an alpha-D-mannosylinositol-1-phosphodihydroceramide + GDP + H(+)

Direction not assertedBalance undeterminableRhea 66300

an alpha-mannosylinositol-1-phosphoceramide + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) = an inositol-1-phospho-alpha-mannosylinositol-1-phosphoceramide + a 1,2-diacyl-sn-glycerol

Direction not assertedBalance undeterminableRhea 66304

an inositol-1-phosphoceramide + GDP-alpha-D-mannose = an alpha-mannosylinositol-1-phosphoceramide + GDP + H(+)

Direction not assertedBalance undeterminableRhea 66308

an alpha-mannosylinositol-1-phosphoceramide + H2O = a D-mannosyl-alpha-1->6-inositol-1-phosphate + an N-acyl-sphingoid base + H(+)

Direction not assertedBalance undeterminableRhea 66312

an inositol phosphomannosyl-alpha-1->6-inositol-1-phospho-N-acyl-4R-hydroxysphinganine + H2O = alpha-D-mannosyl-di-(inositol-1-phosphate) + an N-acyl-(4R)-4-hydroxysphinganine + H(+)

Direction not assertedBalance undeterminableRhea 66316

2',3'-cGAMP(out) = 2',3'-cGAMP(in)

ReversibleBalancedTransportRhea 66320

iodide(out) = iodide(in)

ReversibleBalancedTransportRhea 66324

taurine(out) = taurine(in)

ReversibleBalancedTransportRhea 66328

L-aspartate(out) = L-aspartate(in)

Left to rightBalancedTransportRhea 66332

L-glutamate(out) = L-glutamate(in)

ReversibleBalancedTransportRhea 66336

1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(in) + ATP + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(out) + ADP + phosphate + H(+)

Left to rightBalancedTransportRhea 66340

a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out) + ADP + phosphate + H(+)

Left to rightBalance undeterminableTransportRhea 66344

3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]propanoyl-CoA + A = (2E)-3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]prop-2-enoyl-CoA + AH2

Direction not assertedBalancedRhea 66348

(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-indene-4-carboxyl-CoA + NAD(+) = (5R,7aS)-5-hydroxy-7a-methyl-1-oxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + NADH + H(+)

Direction not assertedBalancedRhea 66352

(5R,7aS)-5-hydroxy-7a-methyl-1-oxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + NAD(+) = (7aS)-7a-methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + NADH + H(+)

Direction not assertedBalancedRhea 66356

(7aS)-7a-methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H2O = (3E)-2-(2-carboxylatoethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA + H(+)

Direction not assertedBalancedRhea 66360

(3E)-2-(2-carboxylatoethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA + H2O = 6-methyl-3,7-dioxodecanedioyl-CoA

Direction not assertedBalancedRhea 66364

6-methyl-3,7-dioxodecanedioyl-CoA + CoA = 4-methyl-5-oxo-octanedioyl-CoA + acetyl-CoA

Direction not assertedBalancedRhea 66368

sn-glycerol 3-phosphate + H2O = glycerol + phosphate

Direction not assertedBalancedRhea 66372

D-erythrose 4-phosphate + H2O = D-erythrose + phosphate

Direction not assertedBalancedRhea 66376

glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)

Left to rightBalancedTransportRhea 66380

(2E,6E,10E,14E)-geranylfarnesol = scalar-17(25)-en-19-ol

Direction not assertedBalancedRhea 66384

prostaglandin E2(in) + ATP + H2O = prostaglandin E2(out) + ADP + phosphate + H(+)

Left to rightBalancedTransportRhea 66388

prostaglandin E1(in) + ATP + H2O = prostaglandin E1(out) + ADP + phosphate + H(+)

Left to rightBalancedTransportRhea 66392

cholate(in) + glutathione(in) + ATP + H2O = cholate(out) + glutathione(out) + ADP + phosphate + H(+)

Left to rightBalancedTransportRhea 66396

glycocholate(in) + glutathione(in) + ATP + H2O = glycocholate(out) + glutathione(out) + ADP + phosphate + H(+)

Left to rightBalancedTransportRhea 66400

taurocholate(in) + glutathione(in) + ATP + H2O = taurocholate(out) + glutathione(out) + ADP + phosphate + H(+)

Left to rightBalancedTransportRhea 66404

glycochenodeoxycholate(in) + glutathione(in) + ATP + H2O = glycochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)

Left to rightBalancedTransportRhea 66408

taurochenodeoxycholate(in) + glutathione(in) + ATP + H2O = taurochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)

Left to rightBalancedTransportRhea 66412

glycoursodeoxycholate(in) + glutathione(in) + ATP + H2O = glycoursodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)

Left to rightBalancedTransportRhea 66416

tauroursodeoxycholate(in) + glutathione(in) + ATP + H2O = tauroursodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)

Left to rightBalancedTransportRhea 66420

leukotriene B4(in) + ATP + H2O = leukotriene B4(out) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 66424

D-arabinose(out) + H(+)(out) = D-arabinose(in) + H(+)(in)

Direction not assertedBalancedTransportRhea 66428

L-galactose(out) + H(+)(out) = L-galactose(in) + H(+)(in)

Direction not assertedBalancedTransportRhea 66432

pentan-3-one + NADP(+) = pent-1-en-3-one + NADPH + H(+)

Direction not assertedBalancedRhea 66436

butan-2-one + NADP(+) = but-3-en-2-one + NADPH + H(+)

Direction not assertedBalancedRhea 66440

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