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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

26,251–26,300 of 31,435, by identifier

Mg(2+)(out) + phosphate(in) + ATP(out) = Mg(2+)(in) + phosphate(out) + ATP(in)
Direction not assertedBalancedTransportRhea 65840
ADP(out) + phosphate(in) + H(+)(out) = ADP(in) + phosphate(out) + H(+)(in)
Direction not assertedBalancedTransportRhea 65844
a 3-oxo-Delta(1)-steroid + A + H2O = a steroid 1,3-dione + AH2
Direction not assertedBalance undeterminableRhea 65848
a 3-oxo-Delta(1)-steroid + H2O = a 1-hydroxy-3-oxo steroid
Direction not assertedBalance undeterminableRhea 65852
a 1-hydroxy-3-oxo steroid + A = a steroid 1,3-dione + AH2
Direction not assertedBalance undeterminableRhea 65856
Delta(1)-dihydrotestosterone + A + H2O = 17beta-hydroxyandrostan-1,3-dione + AH2
Direction not assertedBalancedRhea 65860
5alpha-androst-1-ene-3,17-dione + A + H2O = 5alpha-androstan-1,3,17-trione + AH2

Direction not assertedBalancedRhea 65864

Delta(1)-dihydrotestosterone + H2O = 1,17beta-dihydroxyandrostan-3-one

Direction not assertedBalancedRhea 65868

1,17beta-dihydroxyandrostan-3-one + A = 17beta-hydroxyandrostan-1,3-dione + AH2

Direction not assertedBalancedRhea 65872

5alpha-androst-1-ene-3,17-dione + H2O = 1-hydroxy-5alpha-androstan-3,17-dione

Direction not assertedBalancedRhea 65876

1-hydroxy-5alpha-androstan-3,17-dione + A = 5alpha-androstan-1,3,17-trione + AH2

Direction not assertedBalancedRhea 65880

3-hydroxy-L-kynurenine + 2-oxoglutarate = xanthurenate + L-glutamate + H2O

Direction not assertedBalancedRhea 65884

3-hydroxy-L-kynurenine + 2-oxoglutarate = 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + L-glutamate

Direction not assertedBalancedRhea 65888

4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate = xanthurenate + H2O

Direction not assertedBalancedRhea 65892

L-kynurenine + glyoxylate = kynurenate + glycine + H2O

Left to rightBalancedRhea 65896

3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O

Left to rightBalancedRhea 65900

3-hydroxy-L-kynurenine + glyoxylate = 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + glycine

Direction not assertedBalancedRhea 65904

3-hydroxy-L-kynurenine + pyruvate = xanthurenate + L-alanine + H2O

Direction not assertedBalancedRhea 65908

3-hydroxy-L-kynurenine + pyruvate = 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + L-alanine

Direction not assertedBalancedRhea 65912

L-kynurenine + pyruvate = kynurenate + L-alanine + H2O

Direction not assertedBalancedRhea 65916

L-kynurenine + pyruvate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-alanine

Direction not assertedBalancedRhea 65920

2-heptyl-1-hydroxy-4(1H)-quinolinone + S-adenosyl-L-methionine = 2-heptyl-1-methoxy-4(1H)-quinolinone + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 65924

3-bromo-2-heptyl-1-hydroxy-4(1H)-quinolinone + S-adenosyl-L-methionine = 3-bromo-2-heptyl-1-methoxy-4(1H)-quinolinone + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 65928

3-methyl-1-oxo-2-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1,5-dihydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile + S-adenosyl-L-methionine = 3,5-dimethyl-1-oxo-2-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1,5-dihydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 65932

beta-D-mannose = beta-D-glucose

Direction not assertedBalancedRhea 65936

GDP-alpha-D-glucose + (R)-glycerate = (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + GDP + H(+)

Direction not assertedBalancedRhea 65940

CTP + AH2 + S-adenosyl-L-methionine = 3'-deoxy-3',4'-didehydro-CTP + 5'-deoxyadenosine + L-methionine + A + H2O + H(+)

Direction not assertedBalancedRhea 65944

a 2'-deoxyadenosine in DNA + acetyl-CoA + AH2 + NH4(+) + O2 = a N(6)-methylcarbamoyl-2'-deoxyadenosine in DNA + A + CoA + 2 H2O + H(+)

Direction not assertedBalance undeterminableRhea 65948

2 a quinone + NADH + H(+) = 2 a 1,4-benzosemiquinone + NAD(+)

Direction not assertedBalance undeterminableRhea 65952

estrone 3-sulfate(out) + ATP + H2O = estrone 3-sulfate(in) + ADP + phosphate + H(+)

Left to rightBalancedTransportRhea 65956

leukotriene C4(out) + ATP + H2O = leukotriene C4(in) + ADP + phosphate + H(+)

Left to rightBalancedTransportRhea 65960

taurocholate(out) + ATP + H2O = taurocholate(in) + ADP + phosphate + H(+)

Left to rightBalancedTransportRhea 65964

17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ADP + phosphate + H(+)

Left to rightBalancedTransportRhea 65968

a peptide antigen(in) + ATP + H2O = a peptide antigen(out) + ADP + phosphate + H(+)

Left to rightBalance undeterminableTransportRhea 65972

7-dehydrocholesterol + hnu = previtamin D3

Direction not assertedBalance undeterminableRhea 65976

previtamin D3 + hnu = tachysterol 3

Direction not assertedBalance undeterminableRhea 65980

previtamin D3 + hnu = lumisterol 3

Direction not assertedBalance undeterminableRhea 65984

previtamin D3 = calciol

Direction not assertedBalancedRhea 65988

calciol + hnu = 5,6-trans-vitamin D3

Direction not assertedBalance undeterminableRhea 65992

Co(I)-[glycine betaine-specific corrinoid protein] + glycine betaine + H(+) = methyl-Co(III)-[glycine betaine-specific corrinoid protein] + N,N-dimethylglycine

Direction not assertedBalance undeterminableRhea 65996

methyl-Co(III)-[glycine betaine-specific corrinoid protein] + (6S)-5,6,7,8-tetrahydrofolate = Co(I)-[glycine betaine-specific corrinoid protein] + (6S)-5-methyl-5,6,7,8-tetrahydrofolate + H(+)

Direction not assertedBalance undeterminableRhea 66000

methyl-Co(III)-[glycine betaine-specific corrinoid protein] + coenzyme M = Co(I)-[glycine betaine-specific corrinoid protein] + methyl-coenzyme M + H(+)

Direction not assertedBalance undeterminableRhea 66004

(5R)-5-hydroxy-L-lysyl-[collagen] + L-methionyl-[collagen] + H2O2 = [collagen]-(5R)-5-hydroxy-L-lysyl-N-S-L-methionyl-[collagen] + 2 H2O + H(+)

Direction not assertedBalance undeterminableRhea 66008

(5R)-5-hydroxy-L-lysyl-[collagen] + L-methionyl-[collagen] + hypobromite = [collagen]-(5R)-5-hydroxy-L-lysyl-N-S-L-methionyl-[collagen] + bromide + H2O + H(+)

Direction not assertedBalance undeterminableRhea 66012

bromide + H2O2 = hypobromite + H2O

Left to rightBalancedRhea 66016

L-lysyl-[collagen] + L-methionyl-[collagen] + H2O2 = [collagen]-L-lysyl-N-S-L-methionyl-[collagen] + 2 H2O + H(+)

Left to rightBalance undeterminableRhea 66020

L-lysyl-[collagen] + L-methionyl-[collagen] + hypobromite = [collagen]-L-lysyl-N-S-L-methionyl-[collagen] + bromide + H2O + H(+)

Left to rightBalance undeterminableRhea 66024

L-arginyl-[methyl-coenzyme M reductase] + AH2 + 2 S-adenosyl-L-methionine = (5S)-C-methyl-L-arginyl-[methyl-coenzyme M reductase] + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)

Direction not assertedBalance undeterminableRhea 66028

GDP-alpha-D-glucose + alpha-D-mannose 1-phosphate = alpha-D-glucose 1-phosphate + GDP-alpha-D-mannose

Direction not assertedBalancedRhea 66032

a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ATP + H2O = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ADP + phosphate + H(+)

Left to rightBalance undeterminableTransportRhea 66036

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