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CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Reach

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

25,401–25,450 of 31,435, by identifier

3-hydroxy-3-(3,4-dihydroxyphenyl)propanoyl-CoA = 3,4-dihydroxybenzaldehyde + acetyl-CoA
Direction not assertedBalancedRhea 62428
a uridine in tRNA + S-adenosyl-L-methionine = a 3-[(3S)-3-amino-3-carboxypropyl]uridine in tRNA + S-methyl-5'-thioadenosine + H(+)
Direction not assertedBalance undeterminableRhea 62432
L-lyxonate = 2-dehydro-3-deoxy-L-arabinonate + H2O
Direction not assertedBalancedRhea 62436
[(1->4)-alpha-D-galacturonosyl methyl ester](n) = [(1->4)-alpha-D-galacturonosyl methyl ester](n-1) + 4-deoxy-6-O-methyl-L-threo-hex-4-enopyranuronate
Direction not assertedBalance undeterminableRhea 62440
L-canavanine + L-ornithine = L-canaline + L-arginine + H(+)
Direction not assertedBalancedRhea 62444
L-glutamyl-5'-AMP + holo-[peptidyl-carrier protein] = L-glutamyl-[peptidyl-carrier protein] + AMP + H(+)
Direction not assertedBalance undeterminableRhea

62448

holo-[peptidyl-carrier protein] + L-glutamate + ATP = L-glutamyl-[peptidyl-carrier protein] + AMP + diphosphate

Direction not assertedBalance undeterminableRhea 62452

L-glutamate + ATP + H(+) = L-glutamyl-5'-AMP + diphosphate

Direction not assertedBalancedRhea 62456

holo-[aryl-carrier protein] + 3,4-dihydroxybenzoate + ATP = 3,4-dihydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate

Direction not assertedBalance undeterminableRhea 62460

1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O = 2-nonadioyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)

Left to rightBalancedRhea 62464

3,4-dihydroxybenzoate + ATP + H(+) = 3,4-dihydroxybenzoyl-5'-AMP + diphosphate

Direction not assertedBalancedRhea 62468

1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 2-nonadioyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine

Left to rightBalancedRhea 62472

3,4-dihydroxybenzoyl-5'-AMP + holo-[aryl-carrier protein] = 3,4-dihydroxybenzoyl-[aryl-carrier protein] + AMP + H(+)

Direction not assertedBalance undeterminableRhea 62476

1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O = 2-glutaroyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)

Left to rightBalancedRhea 62480

1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O = 2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + hexadecanoate + H(+)

Left to rightBalancedRhea 62484

1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + hexadecanoate + H(+)

Left to rightBalancedRhea 62488

holo-[peptidyl-carrier protein] + L-arginine + ATP = L-arginyl-[peptidyl-carrier protein] + AMP + diphosphate

Direction not assertedBalance undeterminableRhea 62492

L-arginine + ATP + H(+) = L-arginyl-AMP + diphosphate

Direction not assertedBalancedRhea 62496

L-arginyl-AMP + holo-[peptidyl-carrier protein] = L-arginyl-[peptidyl-carrier protein] + AMP + H(+)

Direction not assertedBalance undeterminableRhea 62500

3-amino-5-hydroxybenzoate + holo-[aryl-carrier protein] + ATP = 3-amino-5-hydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate

Direction not assertedBalance undeterminableRhea 62504

1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + (9Z-octadecenoyl)-sn-glycero-3-phosphocholine

Direction not assertedBalancedRhea 62508

melatonin + 2-oxoglutarate + O2 = 2-hydroxymelatonin + succinate + CO2

Direction not assertedBalancedRhea 62512

a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-N-acetyl-alpha-D-galactosamine = a ganglioside GA2 + UDP + H(+)

Left to rightBalance undeterminableRhea 62516

a cytidine in rRNA + S-adenosyl-L-methionine = an N(4)-methylcytidine in rRNA + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalance undeterminableRhea 62520

cytidine(839) in 12S rRNA + S-adenosyl-L-methionine = N(4)-methylcytidine(839) in 12S rRNA + S-adenosyl-L-homocysteine + H(+)

Left to rightBalancedRhea 62524

digoxin + 2 Fe(II)-[cytochrome c] + 3 H(+) = dihydrodigoxin + 2 Fe(III)-[cytochrome c]

Direction not assertedBalance undeterminableRhea 62528

digitoxin + 2 Fe(II)-[cytochrome c] + 3 H(+) = dihydrodigitoxin + 2 Fe(III)-[cytochrome c]

Direction not assertedBalance undeterminableRhea 62532

digoxigenin + 2 Fe(II)-[cytochrome c] + 3 H(+) = dihydrodigoxigenin + 2 Fe(III)-[cytochrome c]

Direction not assertedBalance undeterminableRhea 62536

ouabain + 2 Fe(II)-[cytochrome c] + 3 H(+) = dihydroouabain + 2 Fe(III)-[cytochrome c]

Direction not assertedBalance undeterminableRhea 62540

ouabagenin + 2 Fe(II)-[cytochrome c] + 3 H(+) = dihydroouabagenin + 2 Fe(III)-[cytochrome c]

Direction not assertedBalance undeterminableRhea 62544

a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + UDP-alpha-D-galactose = a neolactoside nLc6Cer + UDP + H(+)

Left to rightBalance undeterminableRhea 62548

a beta-D-glucosylceramide + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP + H(+)

Left to rightBalance undeterminableRhea 62552

3,4-dihydroxyphenylacetate + H(+) = 4-methylcatechol + CO2

Direction not assertedBalancedRhea 62556

(4R)-limonene + A + H2O = (4R)-perillyl alcohol + AH2

Direction not assertedBalancedRhea 62560

(4S)-limonene + A + H2O = (4S)-perillyl alcohol + AH2

Direction not assertedBalancedRhea 62564

S-benzyl-L-cysteinylglycine + H2O = S-benzyl-L-cysteine + glycine

Left to rightBalancedRhea 62568

S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteinylglycine + H2O = S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine + glycine

Direction not assertedBalancedRhea 62572

L-cystine(out) + ATP + H2O = L-cystine(in) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 62576

D-cystine(out) + ATP + H2O = D-cystine(in) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 62580

L-tyrosine(out) + ATP + H2O = L-tyrosine(in) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 62584

2-hydroxy-2-(4-hydroxyphenyl)acetate + H(+) = 4-hydroxybenzyl alcohol + CO2

Direction not assertedBalancedRhea 62588

(S)-8-oxocitronellyl enol + NADP(+) = (6E)-8-oxogeranial + NADPH + H(+)

Direction not assertedBalancedRhea 62592

(S)-8-oxocitronellyl enol + NAD(+) = (6E)-8-oxogeranial + NADH + H(+)

Direction not assertedBalancedRhea 62596

(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 = (5S)-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate

Left to rightBalancedRhea 62600

(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = 7-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate

Direction not assertedBalancedRhea 62604

ubiquinone-10 + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + ubiquinol-10

Left to rightBalancedRhea 62608

adenosine(1832) in 18S rRNA + S-adenosyl-L-methionine = N(6)-methyladenosine(1832) in 18S rRNA + S-adenosyl-L-homocysteine + H(+)

Left to rightBalancedRhea 62612

a lactoside III(4)-a-Fuc-Lc4Cer + GDP-beta-L-fucose = a lactoside IV(2),III(4)-a-[Fuc]2-Lc4Cer + GDP + H(+)

Left to rightBalance undeterminableRhea 62616

a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O

Direction not assertedBalance undeterminableRhea 62620

[glutaredoxin]-dithiol + a hydroperoxide = [glutaredoxin]-disulfide + an alcohol + H2O

Direction not assertedBalance undeterminableRhea 62624

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