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CompoundsSubstances with curated findings
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ProteinsTransporters and enzymes
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

25,351–25,400 of 31,435, by identifier

(E)-ascladiol + A = patulin + AH2
Direction not assertedBalancedRhea 62228
a thymidine(6-4)thymidine in DNA = a thymidine dimer in DNA
Direction not assertedBalance undeterminableRhea 62232
a cytidine(6-4)cytidine in DNA = a cytidine dimer in DNA + H(+)
Direction not assertedBalance undeterminableRhea 62236
a thymidine(6-4)cytidine in DNA = a thymine-cytidine dinucleotide in DNA
Direction not assertedBalance undeterminableRhea 62240
a cytidine(6-4)thymidine in DNA = a cytidine-thymine dinucleotide in DNA
Direction not assertedBalance undeterminableRhea 62244
chloroacetaldehyde + NADP(+) + H2O = chloroacetate + NADPH + 2 H(+)
Direction not assertedBalancedRhea 62248
Zn(2+)(out) + 2 hydrogencarbonate(out) = Zn(2+)(in) + 2 hydrogencarbonate(in)

Left to rightBalancedTransportRhea 62252

Cd(2+)(out) + 2 hydrogencarbonate(out) = Cd(2+)(in) + 2 hydrogencarbonate(in)

Left to rightBalancedTransportRhea 62256

Mn(2+)(out) + 2 hydrogencarbonate(out) = Mn(2+)(in) + 2 hydrogencarbonate(in)

Left to rightBalancedTransportRhea 62260

selenite(out) + Zn(2+)(out) + hydrogencarbonate(out) = selenite(in) + Zn(2+)(in) + hydrogencarbonate(in)

Direction not assertedBalancedTransportRhea 62264

(R)-2-hydroxy-3-methylbutanoate + NADP(+) = 3-methyl-2-oxobutanoate + NADPH + H(+)

Direction not assertedBalancedRhea 62268

4 (R)-2-hydroxy-3-methylbutanoate + 4 L-leucine + 4 S-adenosyl-L-methionine + 8 ATP = bassianolide + 8 AMP + 4 S-adenosyl-L-homocysteine + 8 diphosphate + 8 H(+)

Direction not assertedBalancedRhea 62272

3 (R)-2-hydroxy-3-methylbutanoate + 3 L-phenylalanine + 3 S-adenosyl-L-methionine + 6 ATP = beauvericin + 6 AMP + 3 S-adenosyl-L-homocysteine + 6 diphosphate + 6 H(+)

Direction not assertedBalancedRhea 62276

10-deacetyl-1-deoxybaccatin III + reduced [NADPH--hemoprotein reductase] + O2 = 10-deacetylbaccatin III + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 62280

L-proline + L-tryptophan + 2 ATP + NADPH = (S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + 2 AMP + 2 diphosphate + NADP(+) + H2O + H(+)

Direction not assertedBalancedRhea 62284

(S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + dimethylallyl diphosphate = (S)-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + diphosphate

Direction not assertedBalancedRhea 62288

(S)-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + A + H(+) = 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + AH2

Direction not assertedBalancedRhea 62292

(+)-premalbrancheamide + 2 FADH2 + 2 chloride + 2 O2 = (+)-malbrancheamide + 2 FAD + 4 H2O

Direction not assertedBalancedRhea 62296

1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + NADPH + H(+) = 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-4H,6H,7H,8H-pyrrolo[1,2-a]pyrazine + NADP(+)

Direction not assertedBalancedRhea 62300

1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-4H,6H,7H,8H-pyrrolo[1,2-a]pyrazine = (+)-premalbrancheamide

Direction not assertedBalancedRhea 62304

(+)-premalbrancheamide + FADH2 + chloride + O2 = (+)-malbrancheamide B + FAD + 2 H2O

Direction not assertedBalancedRhea 62308

salicylate + UDP-alpha-D-glucose = salicylate 2-O-beta-D-glucoside + UDP + H(+)

Direction not assertedBalancedRhea 62312

salicylate + UDP-alpha-D-glucose = 1-O-salicyl-beta-D-glucose + UDP

Direction not assertedBalancedRhea 62316

(+)-premalbrancheamide + FADH2 + chloride + O2 = (+)-isomalbrancheamide B + FAD + 2 H2O

Direction not assertedBalancedRhea 62320

(+)-malbrancheamide B + FADH2 + chloride + O2 = (+)-malbrancheamide + FAD + 2 H2O

Direction not assertedBalancedRhea 62324

(+)-isomalbrancheamide B + FADH2 + chloride + O2 = (+)-malbrancheamide + FAD + 2 H2O

Direction not assertedBalancedRhea 62328

ADP + ATP = adenosine 3'-diphosphate,5'-diphosphate + AMP

Direction not assertedBalancedRhea 62332

AMP + ATP = adenosine 3'-diphosphate,5'-phosphate + AMP + H(+)

Direction not assertedBalancedRhea 62336

(+)-premalbrancheamide + bromide + FADH2 + O2 = (+)-malbrancheamide C + FAD + 2 H2O

Direction not assertedBalancedRhea 62340

6-hydroxydeoxybrevianamide E + dimethylallyl diphosphate = notoamide S + diphosphate

Direction not assertedBalancedRhea 62344

notoamide E + NADPH + O2 + H(+) = notoamide C + NADP(+) + H2O

Direction not assertedBalancedRhea 62348

notoamide E + NADPH + O2 + H(+) = notoamide D + NADP(+) + H2O

Direction not assertedBalancedRhea 62352

8-oxo-GDP + H2O = 8-oxo-GMP + phosphate + H(+)

Left to rightBalancedRhea 62356

FMN-N(5)-peroxide + uracil = (Z)-3-ureidoacrylate + FMN-N(5)-oxide + 2 H(+)

Direction not assertedBalancedRhea 62360

FMN-N(5)-peroxide + thymine = FMN-N(5)-oxide + (Z)-2-methylureidoacrylate + 2 H(+)

Direction not assertedBalancedRhea 62364

Fe(2+)(out) + 2 hydrogencarbonate(out) = Fe(2+)(in) + 2 hydrogencarbonate(in)

Left to rightBalancedTransportRhea 62368

uridine(54) in tRNA + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADPH + H(+) = 5-methyluridine(54) in tRNA + (6S)-5,6,7,8-tetrahydrofolate + NADP(+)

Direction not assertedBalancedRhea 62372

2,4-didehydro-3-deoxy-L-rhamnonate + H2O = (S)-lactate + pyruvate + H(+)

Direction not assertedBalancedRhea 62376

carbaryl + H2O + H(+) = 1-naphthol + methylamine + CO2

Direction not assertedBalancedRhea 62380

cyclic (2R)-2,3-bisphosphoglycerate + H2O = (2R)-2,3-bisphosphoglycerate + 2 H(+)

Direction not assertedBalancedRhea 62384

[(1->2)-beta-D-glucosyl](n) + H2O = [(1->2)-beta-D-glucosyl](n-2) + sophorose

Direction not assertedBalance undeterminableRhea 62388

levoglucosan + NAD(+) = 3-dehydrolevoglucosan + NADH + H(+)

Direction not assertedBalancedRhea 62392

(1S,2S)-pseudoephedrine + NAD(+) = (S)-2-methylamino-1-phenylpropan-1-one + NADH + H(+)

Direction not assertedBalancedRhea 62396

(1R,2S)-ephedrine + NAD(+) = (S)-2-methylamino-1-phenylpropan-1-one + NADH + H(+)

Direction not assertedBalancedRhea 62400

(R)-2-hydroxyhexadecanoate + O2 = pentadecanoate + CO2 + H2O

Direction not assertedBalancedRhea 62404

3,3'-di-O-methyl-4alpha-mannobiose + S-adenosyl-L-methionine = 1,3,3'-tri-O-methyl-4alpha-mannobiose + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 62408

(E)-feruloyl-CoA + H2O = vanillin + acetyl-CoA

Direction not assertedBalancedRhea 62412

(E)-4-coumaroyl-CoA + H2O = 4-hydroxybenzaldehyde + acetyl-CoA

Direction not assertedBalancedRhea 62416

a (R)-2-hydroxy fatty acid + O2 = a fatty acid + CO2 + H2O

Direction not assertedBalance undeterminableRhea 62420

(E)-caffeoyl-CoA + H2O = 3-hydroxy-3-(3,4-dihydroxyphenyl)propanoyl-CoA

Direction not assertedBalancedRhea 62424

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