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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Proteins
Interactions
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Reactions
Reach

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Organisms
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

24,351–24,400 of 31,435, by identifier

cytidine(34) in elongator tRNA(Met) + acetate + ATP = N(4)-acetylcytidine(34) in elongator tRNA(Met) + AMP + diphosphate
Direction not assertedBalancedRhea 58144
ethyl acetate + H2O = ethanol + acetate + H(+)
Direction not assertedBalancedRhea 58148
phosphonoacetaldehyde + NAD(+) + H2O = phosphonoacetate + NADH + 2 H(+)
Direction not assertedBalancedRhea 58152
4 Na(+)(in) + ATP + H2O = 4 Na(+)(out) + ADP + phosphate + H(+)
Direction not assertedBalancedTransportRhea 58156
ent-copalyl diphosphate = dolabradiene + diphosphate
Direction not assertedBalancedRhea 58160
(2E,6E)-farnesyl diphosphate + 2 H2O = 7-epi-ent-eudesmane-5,11-diol + diphosphate
Direction not assertedBalancedRhea 58164
(2E,6E)-farnesyl diphosphate = (-)-5-epi-eremophilene + diphosphate

Direction not assertedBalancedRhea 58168

(2E,6E,10E)-geranylgeranyl diphosphate = beta-pinacene + diphosphate

Direction not assertedBalancedRhea 58172

2 (2E,6E,10E)-geranylgeranyl diphosphate + NADPH + H(+) = all-trans-lycopaoctaene + 2 diphosphate + NADP(+)

Direction not assertedBalancedRhea 58176

(1R,2R,3R)-prephytoene diphosphate + NADPH + H(+) = all-trans-lycopaoctaene + diphosphate + NADP(+)

Direction not assertedBalancedRhea 58180

2 phytyl diphosphate + NADPH + H(+) = (14E,18E)-lycopadiene + 2 diphosphate + NADP(+)

Direction not assertedBalancedRhea 58184

all-trans-lycopene + dimethylallyl diphosphate + H2O = dihydroisopentenyldehydrorhodopin + diphosphate

Direction not assertedBalancedRhea 58188

isopentenyldehydrorhodopin + dimethylallyl diphosphate + H2O = dihydrobisanhydrobacterioruberin + diphosphate

Direction not assertedBalancedRhea 58192

N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate

Left to rightBalance undeterminableRhea 58196

6-aminohexanoate + 2-oxoglutarate = 6-oxohexanoate + L-glutamate

Direction not assertedBalancedRhea 58200

tetrahydroalstonine + reduced [NADPH--hemoprotein reductase] + O2 = dihydroalstonine + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)

Direction not assertedBalance undeterminableRhea 58204

dihydroalstonine + A = alstonine + AH2

Direction not assertedBalancedRhea 58208

ajmalicine + reduced [NADPH--hemoprotein reductase] + O2 = dihydroserpentine + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)

Direction not assertedBalance undeterminableRhea 58212

dihydroserpentine + A = serpentine + AH2

Direction not assertedBalancedRhea 58216

L-lysyl-[protein] + NAD(+) = N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] + nicotinamide + H(+)

Left to rightBalance undeterminableRhea 58220

L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide

Left to rightBalance undeterminableRhea 58224

L-asparaginyl-[protein] + NAD(+) = N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein] + nicotinamide + H(+)

Direction not assertedBalance undeterminableRhea 58228

L-seryl-[protein] + NAD(+) = O-(ADP-D-ribosyl)-L-seryl-[protein] + nicotinamide + H(+)

Left to rightBalance undeterminableRhea 58232

L-tyrosyl-[protein] + NAD(+) = O-(ADP-D-ribosyl)-L-tyrosyl-[protein] + nicotinamide + H(+)

Left to rightBalance undeterminableRhea 58236

S-(ADP-D-ribosyl)-L-cysteinyl-[protein] + H2O = ADP-D-ribose + L-cysteinyl-[protein]

Direction not assertedBalance undeterminableRhea 58240

N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] + H2O = ADP-D-ribose + L-lysyl-[protein]

Direction not assertedBalance undeterminableRhea 58244

5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + H2O = L-glutamyl-[protein] + ADP-D-ribose + H(+)

Left to rightBalance undeterminableRhea 58248

N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein] + H2O = L-asparaginyl-[protein] + ADP-D-ribose

Direction not assertedBalance undeterminableRhea 58252

O-(ADP-D-ribosyl)-L-seryl-[protein] + H2O = ADP-D-ribose + L-seryl-[protein]

Left to rightBalance undeterminableRhea 58256

O-(ADP-D-ribosyl)-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + ADP-D-ribose

Direction not assertedBalance undeterminableRhea 58260

a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine

ReversibleBalance undeterminableRhea 58264

[protein]-C-terminal glycine + NAD(+) = [protein]-C-terminal O-(ADP-D-ribosyl)-glycine + nicotinamide

Left to rightBalance undeterminableRhea 58268

6 ATP = cyclic hexaadenylate + 6 diphosphate

Direction not assertedBalancedRhea 58276

4 ATP = cyclic tetraadenylate + 4 diphosphate

Direction not assertedBalancedRhea 58280

5,6-dihydrothymine + NADP(+) = thymine + NADPH + H(+)

Right to leftBalancedRhea 58284

beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + 25-substituted-cholesterol = 25-substituted-cholesteryl beta-D-glucoside + N-hexadecanoylsphing-4-enine

Direction not assertedBalance undeterminableRhea 58296

25-substituted-cholesteryl beta-D-glucoside + H2O = 25-substituted-cholesterol + D-glucose

Direction not assertedBalance undeterminableRhea 58312

beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine

ReversibleBalancedRhea 58316

beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4E-enine + cholesterol = N-(9Z-octadecenoyl)-sphing-4-enine + cholesteryl 3-beta-D-glucoside

ReversibleBalancedRhea 58324

(Z)-non-6-en-1-ol + NADP(+) = (Z)-non-6-enal + NADPH + H(+)

Direction not assertedBalancedRhea 58328

(E)-non-2-en-1-ol + NADP(+) = (E)-non-2-enal + NADPH + H(+)

Direction not assertedBalancedRhea 58332

a 4-hydroxynonen-1-ol + NADP(+) = a 4-hydroxynonenal + NADPH + H(+)

Direction not assertedBalancedRhea 58336

beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O = chenodeoxycholate + D-glucose

Left to rightBalancedRhea 58340

beta-D-glucosyl-(1->3)-O-lithocholate + H2O = lithocholate + D-glucose

Left to rightBalancedRhea 58344

N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 2-oxoglutarate + 2 O2 = L-arginyl-[protein] + 2 formaldehyde + 2 succinate + 2 CO2

Direction not assertedBalance undeterminableRhea 58348

N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2-oxoglutarate + O2 = N(omega)-methyl-L-arginyl-[protein] + formaldehyde + succinate + CO2

Direction not assertedBalance undeterminableRhea 58352

N(omega)-methyl-L-arginyl-[protein] + 2-oxoglutarate + O2 = L-arginyl-[protein] + formaldehyde + succinate + CO2

Direction not assertedBalance undeterminableRhea 58356

L-lysyl-[protein] + 2-oxoglutarate + O2 = (5S)-5-hydroxy-L-lysyl-[protein] + succinate + CO2

Direction not assertedBalance undeterminableRhea 58360

a medium-chain primary fatty alcohol + NADP(+) = a medium-chain fatty aldehyde + NADPH + H(+)

Direction not assertedBalance undeterminableRhea 58364

(2E,6Z)-nona-2,6-dien-1-ol + NADP(+) = (2E,6Z)-nona-2,6-dienal + NADPH + H(+)

Direction not assertedBalancedRhea 58368

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