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Catalyst

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

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Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

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A reference for what the literature reports. Not medical advice.

Reaction

N(6)-acetyl-L-lysyl-[histone]+waterL-lysyl-[histone]+acetate

Left to right · Balance undeterminable

Inferred

Reference data, not a finding. Evidence key

Catalysts

HDAC3
HDAC4
HDAC1
HDAC7
HDAC2
HDAC11
HDAC8
HDAC9
HDAC5

Rhea RHEA:58196·2026-08-19·CC BY 4.0Reference data

N(6)-acetyl-L-lysyl-[histone]+water→L-lysyl-[histone]+acetate

Catalysts

N(6)-acetyl-L-lysyl-[histone]+waterL-lysyl-[histone]+acetate