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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed

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Atlas Graph Access Compounds Outcomes Proteins Interactions Papers Articles Pathways Processes Anatomy Cell types Organisms Materials Assessments

Reaction

L-tyrosyl-[protein]+NAD(1-)O-(ADP-D-ribosyl)-L-tyrosyl-[protein]+nicotinamide+hydron

Left to right · Balance undeterminable

Inferred

Reference data, not a finding. Evidence key

Catalysts

PARP1

Rhea RHEA:58236·2026-08-19·CC BY 4.0Reference data

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Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

Reaction

L-tyrosyl-[protein]+NAD(1-)O-(ADP-D-ribosyl)-L-tyrosyl-[protein]+nicotinamide+hydron

Left to right · Balance undeterminable

Inferred

Reference data, not a finding. Evidence key

Catalysts

PARP1

Rhea RHEA:58236·2026-08-19·CC BY 4.0Reference data

L-tyrosyl-[protein]+NAD(1-)→O-(ADP-D-ribosyl)-L-tyrosyl-[protein]+nicotinamide+hydron

Catalysts

L-tyrosyl-[protein]+NAD(1-)→O-(ADP-D-ribosyl)-L-tyrosyl-[protein]+nicotinamide+hydron

Catalysts

L-tyrosyl-[protein]+NAD(1-)O-(ADP-D-ribosyl)-L-tyrosyl-[protein]+nicotinamide+hydron

L-tyrosyl-[protein]+NAD(1-)O-(ADP-D-ribosyl)-L-tyrosyl-[protein]+nicotinamide+hydron