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CompoundsSubstances with curated findings
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ReactionsRhea and Human-GEM, by subsystem
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PathwaysReactions grouped under one name
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AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

24,201–24,250 of 31,435, by identifier

a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-RNA + a ribonucleoside 5'-triphosphate = a 5'-end NTP-ribonucleotide-RNA + AMP + H(+)
Direction not assertedBalance undeterminableRhea 57536
a 5'-end NTP-ribonucleotide-RNA + H2O = a 5'-end phospho-ribonucleoside-ribonucleotide-RNA + diphosphate + H(+)
Direction not assertedBalance undeterminableRhea 57540
(S)-beta-macrocarpene + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = zealexin A1 + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)
Direction not assertedBalance undeterminableRhea 57544
(S)-beta-macrocarpene + reduced [NADPH--hemoprotein reductase] + O2 = [(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Direction not assertedBalance undeterminableRhea 57548
[(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + reduced [NADPH--hemoprotein reductase] + O2 = (4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)
Direction not assertedBalance undeterminableRhea 57552
(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + reduced [NADPH--hemoprotein reductase] + O2 = zealexin A1 + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)

Direction not assertedBalance undeterminableRhea 57556

(+)-cis-trans-nepetalactol + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = 7-deoxyloganetate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)

Direction not assertedBalance undeterminableRhea 57560

(+)-cis-trans-nepetalactol + reduced [NADPH--hemoprotein reductase] + O2 = 7-deoxyloganetic alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 57564

7-deoxyloganetic alcohol + reduced [NADPH--hemoprotein reductase] + O2 = 7-deoxyloganetic aldehyde + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)

Direction not assertedBalance undeterminableRhea 57568

7-deoxyloganetic aldehyde + reduced [NADPH--hemoprotein reductase] + O2 = 7-deoxyloganetate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)

Direction not assertedBalance undeterminableRhea 57572

7-deoxyloganate + reduced [NADPH--hemoprotein reductase] + O2 = loganate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 57576

5-(methylsulfanyl)-D-ribulose 1-phosphate = 1-(methylsulfanyl)ribulose 5-phosphate

Direction not assertedBalancedRhea 57580

a flavanone + reduced [NADPH--hemoprotein reductase] + O2 = a 2-hydroxyflavanone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 57584

(2S)-naringenin + reduced [NADPH--hemoprotein reductase] + O2 = (2S)-2-hydroxynaringenin + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 57588

(S)-pinocembrin + reduced [NADPH--hemoprotein reductase] + O2 = (2S)-2-hydroxypinocembrin + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 57592

(S)-eriodictyol + reduced [NADPH--hemoprotein reductase] + O2 = (2S)-2-hydroxyeriodictyol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 57596

a 1-hexacosanoyl-2-acyl-phosphoglycerolipid + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = a 1-[(17Z)-hexacos-17-enoyl]-2-acyl-phosphoglycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O

Direction not assertedBalance undeterminableRhea 57600

a 1-tetracosanoyl-2-acyl-phosphoglycerolipid + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = a 1-[(15Z)-tetracos-15-enoyl]-2-acyl-phosphoglycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O

Direction not assertedBalance undeterminableRhea 57604

(1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol + NAD(+) = 3-chlorocatechol + NADH + H(+)

Direction not assertedBalancedRhea 57608

holo-[compactin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH + 20 H(+) = dihydro-ML-236C-[compactin nonaketide synthase] + 9 CO2 + 11 NADP(+) + 9 CoA + 6 H2O

Direction not assertedBalance undeterminableRhea 57612

dihydro-ML-236C-[compactin nonaketide synthase] + H2O = holo-[compactin nonaketide synthase] + dihydro-ML-236C carboxylate + H(+)

Direction not assertedBalance undeterminableRhea 57616

dihydro-ML-236C carboxylate + reduced [NADPH--hemoprotein reductase] + O2 = ML-236C carboxylate + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)

Direction not assertedBalance undeterminableRhea 57620

dihydro-ML-236C carboxylate + reduced [NADPH--hemoprotein reductase] + O2 = 3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 57624

3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate = ML-236C carboxylate + H2O

Direction not assertedBalancedRhea 57628

ML-236C carboxylate + reduced [NADPH--hemoprotein reductase] + O2 = ML-236A carboxylate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 57632

ML-236A carboxylate + (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] = mevinic carboxylate + holo-[2-methylbutanoate polyketide synthase]

Direction not assertedBalance undeterminableRhea 57636

trichosetin + S-adenosyl-L-methionine = equisetin + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 57648

a ganglioside GA1 + CMP-N-acetyl-beta-neuraminate = a ganglioside GM1alpha + CMP + H(+)

Direction not assertedBalance undeterminableRhea 57652

a ganglioside GD1b + CMP-N-acetyl-beta-neuraminate = a ganglioside GT1balpha + CMP + H(+)

Direction not assertedBalance undeterminableRhea 57656

(+)-valencene + 2 reduced [NADPH--hemoprotein reductase] + 2 O2 = (+)-nootkatone + 2 oxidized [NADPH--hemoprotein reductase] + 3 H2O + 2 H(+)

Direction not assertedBalance undeterminableRhea 57660

(+)-valencene + reduced [NADPH--hemoprotein reductase] + O2 = alpha-nootkatol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 57664

alpha-nootkatol + reduced [NADPH--hemoprotein reductase] + O2 = (+)-nootkatone + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)

Direction not assertedBalance undeterminableRhea 57668

(+)-5-epi-aristolochene + reduced [NADPH--hemoprotein reductase] + O2 = 2beta-hydroxy-5-epi-aristolochene + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 57672

4-epi-eremophilene + reduced [NADPH--hemoprotein reductase] + O2 = 4-epi-eremophilene-2beta-ol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 57676

a flavanone + reduced [NADPH--hemoprotein reductase] + O2 = a flavone + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)

Direction not assertedBalance undeterminableRhea 57680

4-hydroxyestrone + NH4(+) + O2 = pyridinestrone carboxylate + 2 H2O + 2 H(+)

Direction not assertedBalancedRhea 57684

cob(II)inamide + apo-[corrinoid adenosyltransferase] = cob(II)inamide-[corrinoid adenosyltransferase]

Direction not assertedBalance undeterminableRhea 57688

2 cob(II)inamide-[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] = 2 cob(I)inamide-[corrinoid adenosyltransferase] + oxidized [electron-transfer flavoprotein] + 3 H(+)

Direction not assertedBalance undeterminableRhea 57692

cob(I)inamide-[corrinoid adenosyltransferase] + ATP = apo-[corrinoid adenosyltransferase] + adenosylcob(III)inamide + triphosphate

Direction not assertedBalance undeterminableRhea 57696

a 2-demethylmenaquinone + reduced [flavodoxin] + 2 S-adenosyl-L-methionine = a 2-demethyl-8-methylmenaquinone + oxidized [flavodoxin] + 5'-deoxyadenosine + L-methionine + S-adenosyl-L-homocysteine + 3 H(+)

Direction not assertedBalance undeterminableRhea 57700

(2R)-3-(3,4-dihydroxyphenyl)lactate + NADP(+) = 3-(3,4-dihydroxyphenyl)pyruvate + NADPH + H(+)

Direction not assertedBalancedRhea 57704

(E)-coniferaldehyde + UDP-alpha-D-glucose = 4-O-(beta-D-glucosyl)-4-(E)-coniferyl aldehyde + UDP + H(+)

Direction not assertedBalancedRhea 57708

(E)-sinapaldehyde + UDP-alpha-D-glucose = 4-O-(beta-D-glucosyl)-4-trans-sinapoyl aldehyde + UDP + H(+)

Direction not assertedBalancedRhea 57712

hydrogencarbonate + NH4(+) = carbamate + H2O + H(+)

Direction not assertedBalancedRhea 57716

ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)

Right to leftBalancedTransportRhea 57720

oxaloacetate + 2 Na(+)(in) + H(+) = pyruvate + 2 Na(+)(out) + CO2

Direction not assertedBalancedTransportRhea 57724

trans-aconitate + H(+) = itaconate + CO2

Direction not assertedBalancedRhea 57728

all-trans-7,8-dihydroretinol + A = all-trans-retinol + AH2

Direction not assertedBalancedRhea 57732

all-trans-3,4-didehydro-13,14-dihydroretinol + A = all-trans-3,4-didehydroretinol + AH2

Direction not assertedBalancedRhea 57736

a 2,3-saturated meromycolyl-[ACP] + NAD(+) = a trans-Delta(2)-meromycolyl-[ACP] + NADH + H(+)

Direction not assertedBalance undeterminableRhea 57740

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